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Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Resveratrol Levels and All-Cause Mortality in O... - 0 views

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    New study finds no cardiovascular benefits from resveratrol.  It has long been claimed that reserveratrol is the polyphenol from red wine and chocolate that is the source of cardiovascular benefits such as found in the "french paradox".  However, this new study finds that resveratrol provides no benefit.  Studies still point to dark chocolate and red wine as means to reduce inflammation and reduce CVD risk, this study just points away from resveratrol as the source of the benefit.
Nathan Goodyear

Resveratrol up-regulates hepatic uncoupling protein... [Nutr Res. 2012] - PubMed - NCBI - 0 views

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    Not only does resveratrol reduce inflammation, but resveratrol inhibits NAFLD in rats fed a high fat diet.  
Nathan Goodyear

Mechanism of Human SIRT1 Activation by Resveratrol - 0 views

  • The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
  • resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
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    Resveratrol potentially increases life span through SIRT1 activation
Nathan Goodyear

Cambridge Journals Online - Abstract - Resveratrol improves insulin sensitivity, reduce... - 0 views

  • resveratrol improves insulin sensitivity in humans,
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    Resveratrol improves insulin sensitivity
Nathan Goodyear

Nutrition & Metabolism | Full text | Curcumin and resveratrol inhibit Nuclear Factor-ka... - 0 views

  • These data suggest that curcumin and resveratrol may provide a novel and safe approach to reduce or inhibit the chronic inflammatory properties of adipose tissue.
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    Curcumin and Resveratrol inhibit chronic inflammation signaling
Nathan Goodyear

Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits es... - 0 views

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    Resveratrol inhibits ER-alpha in human breast cancer cells providing potential mechanism to inhibit pro growth/pro inflammatory signaling favoring breast cancer.  So maybe, a glass of red wine keeps the breast cancer doctor away??
Nathan Goodyear

The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast ... - 0 views

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    resveratrol in red wine is an aromatase inhibitor.
Nathan Goodyear

Dietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modula... - 0 views

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    Interesting animal study, dietary fructose intake increased insulin and inflammatory signaling.  The authors find that resveratrol had some blocking effect.
Nathan Goodyear

Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placeb... - 0 views

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    Only abstract available.  Resveratrol found to reduce total Testosterone by 23% and DHEAS by 22% in women with PCOS;  a decrease in insulin by 32% and improved insulin sensitivity was also noted.
Nathan Goodyear

Resveratrol reduces endothelial progenitor cells senescence through augmentation of tel... - 0 views

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    Resveratrol reduces EPC ageining through increased Telomerase activity, and thus increasing telomere length.  Estradiol has been shown to do the same.
Nathan Goodyear

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat ... - 0 views

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    Resveratrol shown to inhibit 11beta-hydroxysteroid dehydrogenase I in rat study.
Nathan Goodyear

Up-regulation of adiponectin by resveratrol: The essential roles of the Akt/FOXO1 and A... - 0 views

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    Resveratrol increases adiponectin: very important in obestity treatment, insulin resistance, metabolic syndrome...
Nathan Goodyear

Modulation of NF-[kappa]B-dependent transcription and cell survival by the SIRT1 deacet... - 0 views

  • Treatment of cells with resveratrol, a small-molecule agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region, an effect that correlates with a loss of NF-B-regulated gene expression
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    resveratrol decreases NF-kappa Beta expression and thus reduces inflammation
Nathan Goodyear

ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology : Quercetin a... - 0 views

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    quercetin and resveratrol shown to inhibit estrogen sulfonyltransferase activity.  important implications in estrogen dependent cancers, like breast cancer
Nathan Goodyear

Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airw... - 0 views

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    resveratrol inhibits inflammation in in-vivo airway model, independent of NF-KB
Nathan Goodyear

Potential of resveratrol in anticancer and anti-inflammatory therapy - Udenigwe - 2008 ... - 0 views

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    resveratrol reduces inflammation
Nathan Goodyear

Resveratrol Plus Simvastatin Are Effective in Decreasing IgM Secretion in Asymptomatic ... - 0 views

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    Resveratrol and Simvastatin found to be helpful in lowering IgM levels in Asymptomatic patients with Waldenstrom's lymphoma
Nathan Goodyear

Dose-Dependency of Resveratrol in Providing Health Benefits - 0 views

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    Great review of resveratrol in cancer and other diseases.
Nathan Goodyear

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer d... - 0 views

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    Incredible review of the effects of curcumin, berberine and resveratrol.
Nathan Goodyear

Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macropha... - 0 views

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    In addition to quercetin, resveratrol and pterostilbene inhibit LPS stimulated cytokine production.
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