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There is just no reason to take SSRIs during pregnancy.  SSRIs increase risk of miscarriage, birth defects, preterm birth, newborn behavior problems, pulmonary hypertension...All women considering pregnancy should removed, yet SSRIs are prescribed as if they are candy.

Ultram is a weak norepinephrine and serotonin reuptake inhibitor

SAMe, in SSRI non-responders, resulted in a 46.1% response and a 35.8% remission compared to placebo.

Interesting study.  They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid.   The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.

SSRI's have variable inhibition of CYP.  Fluvoxamine was found to be the most potent inhibitor.  CYP3A4 and CYP2D6 were found to be the main targets of inhibition.