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Nathan Goodyear

Individual diet has sex-dependent effects on vertebrate gut microbiota : Nature Communi... - 0 views

www.nature.com/...ncomms5500.html

gut flora gut microbiome gut microbiota diet nutrition dysbiosis gut

shared by Nathan Goodyear on 26 Jun 15 - No Cached
  • Nathan Goodyear on 26 Jun 15
     
    Sex difference of gut flora has different metabolic effects from the same diet.  Could it all begin in the get?  Are gut flora sexist?  Of course not, but this study highlights the sex difference of the gut flora and the gender different effects.
Nathan Goodyear

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, b... - 0 views

www.nature.com/...ncomms15062

brain brain health probiotics antibiotics gut-brain gut bacteria gut flora gut health gut microbiome gut microbiota gut

shared by Nathan Goodyear on 26 Oct 17 - No Cached
  • Nathan Goodyear on 26 Oct 17
     
    Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

www.sciencedirect.com/...S1931312816305170

gut gut bacteria gut flora gut health gut microbiome gut microbiota diet nutrition

shared by Nathan Goodyear on 02 Jan 17 - No Cached
  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
  • Nathan Goodyear on 02 Jan 17
     
    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

The Gut Microbiota and Type 1 Diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC4761565

diabetes type I diabetes gut gut flora gut health gut microbiome gut microbiota dysbiosis

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • A study by Bosi and colleagues suggested that the increased gut permeability preceded the clinical onset of T1D
  • gut permeability may be an important player in the development of T1D but, as yet, the findings in human studies have shown association but causation will be more difficult to prove.
  • Early childhood (≤ 3 month) introduction to cereals [10, 11] and cow's milk [48] were shown to promote beta cell autoimmunity
  • ...1 more annotation...
  • These findings suggest that prebiotics and probiotics could be potential therapeutic tools to improve gut integrity in various intestinal inflammatory and autoimmune diseases including T1D
  • Nathan Goodyear on 17 Oct 16
     
    another great review article of gut dysbiosis, altered gut permeability and type I diabetes.
Nathan Goodyear

Delivery mode shapes the acquisition and structure of the initial microbiota across mul... - 0 views

www.ncbi.nlm.nih.gov/...PMC2900693

human microbiome gut flora newborns newborn bacteria delivery mode

shared by Nathan Goodyear on 20 Aug 14 - No Cached
  • Nathan Goodyear on 20 Aug 14
     
    Study finds infants born vaginally have gut flora similar to mother's vaginal flora--Lactobacillus, Prevotella, or Sneathia species.  In contrast, those born via C/S have gut flora similar to that on the skin surface--staphylococcus, corynebacterium...
Nathan Goodyear

The chemo-gut study: investigating the long-term effects of chemotherapy on gut microbi... - 0 views

bmccancer.biomedcentral.com/...s12885-019-6473-8

Gut gut health dysbiosis gut microbiota gut flora chemotherapy gut bacteria gut microbiome

shared by Nathan Goodyear on 18 Jun 21 - No Cached
  • Nathan Goodyear on 18 Jun 21
     
    Chemotherapy destroys the gut flora. The full impact is yet to be determined, but initial results don't look good.
Nathan Goodyear

Connections between the human gut microbiome and gestational diabetes mellitus | GigaSc... - 0 views

academic.oup.com/...tween-human-gut-microbiome-and

gestational diabetes LPS lipopolysaccharides dysbiosis gut microbiota gut flora gut microbiome gut bacteria gut health gut

shared by Nathan Goodyear on 03 Aug 17 - No Cached
  • Nathan Goodyear on 03 Aug 17
     
    Gestational Diabetes risk may just begin in the gut flora.
Nathan Goodyear

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epi... - 0 views

aem.asm.org/...3655.full

gut gut bacteria gut flora gut health gut microbiome gut microbiota akkermansia muciniphila

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • Nathan Goodyear on 11 Jul 17
     
    Akkermansia muciniphila found to increase the integrity of the gut mucosal lining.  Important in gut healing and likely a good biomarker of good/bad gut health and integrity.
Nathan Goodyear

Head-injury profoundly affects gut microbiota homeostasis: results of a pilot study - S... - 0 views

www.sciencedirect.com/...S0899900717301387

TBI traumatic brain injury head injury gut gut bacteria gut flora gut health gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 13 Jul 17 - No Cached
  • Nathan Goodyear on 13 Jul 17
     
    New study finds that head injury alters gut bacteria.  This destroys the isolated systems thinking of traditional medicine.  This is the gut-grain connection, but in REVERSE.
Nathan Goodyear

Gut microbiota signatures of longevity - 0 views

www.sciencedirect.com/...S0960982216309277

gut gut bacteria gut flora gut health gut microbiome gut microbiota longevity health

shared by Nathan Goodyear on 21 Nov 16 - No Cached
  • Nathan Goodyear on 21 Nov 16
     
    Gut health the key to longevity?  Or just and effect?  Sorry, just abstract available.  The authors found similarities in the gut commensal population of centurions in China and Italy.
Nathan Goodyear

Gut-brain link grabs neuroscientists : Nature News & Comment - 0 views

www.nature.com/...-grabs-neuroscientists-1.16316

gut flora gut gut microbiome gut microbiota gut-brain autism

shared by Nathan Goodyear on 29 Jun 15 - No Cached
  • Nathan Goodyear on 29 Jun 15
     
    Gut-brain connection via gut microbiome starts to move mainstream.
Nathan Goodyear

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Agg... - 0 views

www.nature.com/srep34477

neurodegenerative disease amyloid alzheimer's disease Parkinson's disease gut gut flora gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 06 Oct 16 - No Cached
  • Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
  • Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
  • Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
  • ...8 more annotations...
  • changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
  • Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
  • exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
  • AS aggregates seed aggregation of tau
  • involvement of the vagus nerve in PD
  • microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
  • the immune system in both AD and PD have now been extensively established
  • TLR2 activation through exposure to bacterial amyloid is pathogenic
  • Nathan Goodyear on 06 Oct 16
     
    Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease.  These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain.   More establishment of the gut-brain connection.  
Nathan Goodyear

Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Lum... - 0 views

ajp.amjpathol.org/...fulltext

gut gut bacteria gut flora gut health gut microbiome gut microbiota inflammation colon cancer cancer lactobacillus reuteri histamine

shared by Nathan Goodyear on 02 Nov 17 - No Cached
  • Nathan Goodyear on 02 Nov 17
     
    Only abstract available here: Gut bacteria, lactobacillus reuteri, could be the key to colon cancer prevention through inflammation control.  What is fascinating is how the gut bacteria influenced epigenetic expression of histidine decarboxylase to increase histamine production.
Nathan Goodyear

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota an... - 0 views

gut.bmj.com/1812

SCFA mediterranean diet gut gut flora gut microbiota diet nutrition

shared by Nathan Goodyear on 09 Nov 16 - No Cached
  • Nathan Goodyear on 09 Nov 16
     
    Mediterranean diet improve gut flora and SCFA
Nathan Goodyear

Akkermansia muciniphila and improved metabolic health during a dietary intervention in ... - 0 views

gut.bmj.com/...gutjnl-2014-308778.abstract

akkermansia muciniphila gut flora gut microbiome gut microbiota metabolism obesity

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Nathan Goodyear on 11 Aug 15
     
    akkermansia muciniphila bacteria associated with improved metabolism following calorie restriction in obese adults.  Again, gut flora effects metabolism
Nathan Goodyear

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syn... - 0 views

www.nature.com/...nature14232.html

metabolic syndrome metabolic endotoxemia gut flora gut microbiota processed foods probiotics microbiome gut inflammation obesity metabolism

shared by Nathan Goodyear on 01 Mar 15 - No Cached
  • Nathan Goodyear on 01 Mar 15
     
    Great article--only abstract available here.  Animal study finds that emulsifiers in process foods alters gut flora resulting in gut inflammation and obesity/metabolic syndrome.  Need an indictment against process foods--here you go.
Nathan Goodyear

Substituting whole grains for refined grains in a 6-wk randomized trial has a modest ef... - 0 views

ajcn.nutrition.org/...ajcn.116.146928.abstract

diet nutrition grains whole grains gut bacteria gut flora gut microbiota gut microbiome gut

shared by Nathan Goodyear on 06 Apr 17 - No Cached
  • Nathan Goodyear on 06 Apr 17
     
    small study finds diet rich in whole grains compared to refined grains improves gut bacteria balance and immune system.  Maybe the key to optimal gut health is the diet?
Nathan Goodyear

PLOS ONE: The Gut Microbiota and Developmental Programming of the Testis in Mice - 0 views

journals.plos.org/...article

hormone hormones Testosterone gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
  • This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
  • Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
  • ...8 more annotations...
  • Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
  • he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
  • Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
  • In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
  • the absence of gut microbiota influenced testosterone levels
  • A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
  • bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
  • This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
  • Nathan Goodyear on 30 Apr 15
     
    gut micro biome effects spermatogenesis, Testosterone production, and the brain-testicle-barrier.
Nathan Goodyear

Frontiers | Bacterial Composition, Genotoxicity, and Cytotoxicity of Fecal Samples from... - 0 views

journal.frontiersin.org/...full

diet nutrition gut bacteria gut gut flora inflammation gut health gut microbiome gut microbiota

shared by Nathan Goodyear on 08 May 17 - No Cached
  • Nathan Goodyear on 08 May 17
     
    Diet influenced gut bacteria is key to controlling gut inflammation.
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