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Nathan Goodyear

Acta Pharmacologica Sinica - Progress in studies of huperzine A, a natural cholinestera... - 0 views

www.nature.com/...aps20061a.html

Huperzine-A Huperzine Alzheimer's disease brain NMDA organophosphate organophosphates

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    This study found that Huperzine A improved memory deficits in elderly and those with Alzheimer's disease.  Huperzine A is an acetylcholinisterase inhibitor, thereby increasing the neurotransmitter acetylcholine.  Huperzine A has also been shown to be neuroprotective through its antagonistic action with the NMDA receptors. Huperzine A has been shown to be protective from organophosphate toxicity.
Nathan Goodyear

http://www.update-software.com/BCP/WileyPDF/EN/CD007365.pdf - 0 views

www.update-software.com/...CD007365.pdf

huperzine huperzine-A huperzine A dementia Alzheimer's alzheimer's disease Alzheimers

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.   There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  
Nathan Goodyear

NeuroSignals 2005, Vol. 14, No. 1-2 - Neuroprotective Effects of Huperzine A - FullText... - 0 views

www.karger.com/...85387

Huperzine-A Huperzine brain cognition oxidative stress Alzheimer's cognitive decline NMDA

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Huperzine A is a great neuroprotector.  Huperzine A is a acetycholinesterase inhibitor. But, Huperzine A also reduces oxidative stress, reduces beta-Amyloid, protects mitochondria, antagonizes NMDA receptors and thus reduces excitotoxicity, and regulates apoptosis.
Nathan Goodyear

Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treat... - 0 views

www.sciencedirect.com/...S0197458013005721

Huperzine Huperzine-A brain Alzheimer's Alzheimers alzheimer's disease iron Fe disease

shared by Nathan Goodyear on 09 Apr 14 - No Cached
  • Nathan Goodyear on 09 Apr 14
     
    Huperzine reduces CNS iron.  This is in addition to the other neuroprotective effects of Huperzine A
Nathan Goodyear

Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression o... - 0 views

www.sciencedirect.com/...S0014488612001550

Huperzine Huperzine-A MS multiple Sclerosis experimental autoimmune encephalopathy EAE inflammation autoimmune

shared by Nathan Goodyear on 09 Apr 14 - No Cached
  • Nathan Goodyear on 09 Apr 14
     
    Huperzine A reduces EAE, an experimental MS model.  Thus, huperzine A has a anti-inflammatory effect in the brain.  
Nathan Goodyear

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease - 0 views

www.chinaphar.com/...391.pdf

Huperzine-A memory cognition Alzheimer's Alzheimer's disease acetylcholinesterase inhibitor

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    small study, but well designed that showed that huperzine A supplementation improved executive function in Alzheimer's patients. Huperzine A is an acetylcholinesterase inhibitor.
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

iospress.metapress.com/...jp517wt324588874

Huperzine-A Huperzine Alzheimer's alzheimer's disease Alzheimers dementia mitochondria Beta-amyloid protein

shared by Nathan Goodyear on 09 Apr 14 - No Cached
  • Nathan Goodyear on 09 Apr 14
     
    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Huperzine A promotes hippocampal neurogenesis in vitro and in vivo - 0 views

www.sciencedirect.com/...S0006899313002618

Huperzine Huperzine-A neurogenesis hippocampus

shared by Nathan Goodyear on 09 Apr 14 - No Cached
  • Nathan Goodyear on 09 Apr 14
     
    Huperzine A increases hippocampal neural stem cell proliferation--neurogenesis.  This study an animal study.
Nathan Goodyear

Efficacy of tablet huperzine-A on me... [Zhongguo Yao Li Xue Bao. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8701750

Huperzine A Huperzine-A alzheimer's disease Alzheimer's disease memory cognition brain

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.
Nathan Goodyear

Effects of huperzine A on memory def... [Pharmacol Biochem Behav. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16687166

Huperzine-A Huperzine A brain NGF nerve growth factor BDNF derived memory

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Huperzine A increases production of Nerve Growth Factor and Brain derived growth Factor.
Nathan Goodyear

Huperzine a as potential treatment of Alzheim... [Chem Biodivers. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21766442

Huperzine-A Alzheimer's disease Alzheimer's

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Huperzine A at doses up to 400 mcg shown to benefit people with Alzheimer's disease, with no significant side effects.
Nathan Goodyear

Huperzine A for Alzheimer's disease. [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425924

alzheimer disease Alzheimer's disease Alzheimer's Huperzine-A memory cognition

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?
Nathan Goodyear

Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis - 0 views

www.hindawi.com/...363985

dementia Alzheimer's alzheimer's disease alzheimer disease huperzine A

shared by Nathan Goodyear on 30 Sep 14 - No Cached
  • Nathan Goodyear on 30 Sep 14
     
    Good review of the data on Huperzine A and Alzheimer's dementia.
Nathan Goodyear

Efficacy and safety of natural acetylcholine... [J Neural Transm. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19221692

Huperzine A Huperzine-A cognition Alzheimer's disease

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Huperzine A shown to improve cognition in Alzheimer's disease.  This was a meta-analysis.
Nathan Goodyear

[Clinical efficacy and safety of hupe... [Zhonghua Yi Xue Za Zhi. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12181083

Huperzine A Huperzine-A cognition Alzheimer's disease

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Huperzine A improved cognition and behavior in Alzheimer's disease
Nathan Goodyear

Treating senile dementia with traditional Chinese medicine - 0 views

www.ncbi.nlm.nih.gov/...PMC2684515

herbs natural dementia Alzheimer's Alzheimers alzheimer's disease RG3 huperzine A huperzine-A huperzine chinese medicine ginseng

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    Great review of the literature supporting herbal therapies in the treatment of dementia.
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

www.plosone.org/...fetchObject.action

alzheimer's disease Alzheimer's disease Alzheimers dementia huperzine A

shared by Nathan Goodyear on 30 Sep 14 - No Cached
  • Nathan Goodyear on 30 Sep 14
     
    Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.
Nathan Goodyear

Alzheimer's Disease Clinical and Research Update for Health Care Practitioners - 0 views

www.ncbi.nlm.nih.gov/...PMC3776389

Alzheimer's disease cognition memory Alzheimers brain brain health alpha-GPC phosphatidyl serine Huperzine A choline

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Alpha GPC, phosphatidylserine, Huperzine A, and choline show promise as nutraceutical agents for enhancing cognitive performance and slowing cognitive decline
  • Alpha GPC, also known as L-Alpha Glycerylphosphorylcholine, a naturally occurring form of choline, acts as a parasympathomimetic acetylcholine precursor and has shown promise in improving cognitive symptoms related to AD, vascular dementia, and multi-infarct dementia
  • Phosphatidylserine is a widely abundant anionic phospholipid in the human body and has been shown to improve age-related cognitive changes
  • ...2 more annotations...
  • Huperzine A (a natural cholinesterase inhibitor) has been linked to improved memory performance in elderly people with benign forgetfulness, as well as patients with AD and vascular dementia
  • Cholinesterase inhibitors have been shown to have neuroprotective properties in patients with mild [37] as well as moderate-to-advanced AD
  • Nathan Goodyear on 26 Sep 17
     
    good review of treatment for Alzheimer's, both prescription and natural.
Nathan Goodyear

Alzheimer's Disease: The Pros and Cons of Pharmaceutical, Nutritional, Botanical, and S... - 0 views

www.altmedrev.com/...223.pdf

BDNF Huperzine-A Alzheimer's disease

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    I like the inclusion of western medicine and more "natural" medicine in the biochemical treatment of Alzheimer's disease. Brief review of BDNF.
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