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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
Nathan Goodyear

Testosterone: More Than Having the Guts to Win the Tour de France - 0 views

www.sciencedirect.com/...S1074761313003439

Testosterone gut flora gut microbiome gut microbiota autoimmune disease diabetes

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • female adult mice have microbiomes similar to those of prepubescent mice of both sexes;
  • the commensal microbial community in adult male mice significantly deviates from this shared initial pool.
  • the microbiome in castrated adult males clearly shifts away from that of normal adult males and is closer to the microbiome of females
  • ...10 more annotations...
  • The incidence of T1D in these mice is positively correlated with the “femaleness” of the microbiota
  • These results support the hypothesis that the host androgen level is influential in determining the composition of the microbiota, which in turn affects T1D initiation and progression
  • a high testosterone level enriches the microbiota for specific organisms such as segmented filamentous bacteria (SFB) and Escherichia coli or Shigella–like (SECS) strains.
  • A minimum level of testosterone and specific male-enriched microbes working together upregulate M2 macrophage and IFN-γ producing T cells in pancreatic lymph nodes. Microarray data show that both the IFN-γ and IL-1β pathways are also stimulated.
  • These microbes also upregulate host testosterone
  • In four independent experiments, the authors found no universal unique “male microbiome”
  • they did find that four distinct combinations of microbial groupings (with an interesting lack of overlap at the individual family level in the four experiments) were enhanced by androgen
  • one species consists of the segmented filamentous bacteria (SFB) and belongs to the Firmicutes, whereas the other is an Escherichia coli or Shigella–like (SECS) strain belonging to the Proteobacteria
  • colonization with protective microbiomes—e.g., SPF microbiota, SFB, and SECS—is positively correlated with high blood testosterone levels in male mice
  • A direct implication of this study is that probiotic administration or fecal transplantation is a theoretically possible approach to protection against T1D
  • Nathan Goodyear on 30 Apr 15
     
    nice summary of article on the relationship between Testosteorne and gut microbiome in autoimmune disease.
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

gut flora gut microbiome gut microbiota estrogen metabolites metabolism hormone hormones women gut

shared by Nathan Goodyear on 06 May 15 - No Cached
  • Nathan Goodyear on 06 May 15
     
    women with increased gut microbiome diversity found to have increased estrogen metabolites compared to parent estrogen i.e. gut microbiome diversity in women effects estrogen metabolism. 
Nathan Goodyear

Variable responses of human microbiomes to dietary supplementation with resistant starc... - 0 views

microbiomejournal.biomedcentral.com/...s40168-016-0178-x

gut gut microbiome gut bacteria gut flora gut microbiota diet butyrate fiber

shared by Nathan Goodyear on 08 Jun 17 - No Cached
  • Nathan Goodyear on 08 Jun 17
     
    Research suggests that the gut microbiome may determine the effectiveness of therapy.  The future may be to determine the gut micrboiome, which will then dictate therapy.
Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

www.sciencedirect.com/...S1931312816305170

gut gut bacteria gut flora gut health gut microbiome gut microbiota diet nutrition

shared by Nathan Goodyear on 02 Jan 17 - No Cached
  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
  • Nathan Goodyear on 02 Jan 17
     
    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
Nathan Goodyear

Gut-brain link grabs neuroscientists : Nature News & Comment - 0 views

www.nature.com/...-grabs-neuroscientists-1.16316

gut flora gut gut microbiome gut microbiota gut-brain autism

shared by Nathan Goodyear on 29 Jun 15 - No Cached
  • Nathan Goodyear on 29 Jun 15
     
    Gut-brain connection via gut microbiome starts to move mainstream.
Nathan Goodyear

Connections between the human gut microbiome and gestational diabetes mellitus | GigaSc... - 0 views

academic.oup.com/...tween-human-gut-microbiome-and

gestational diabetes LPS lipopolysaccharides dysbiosis gut microbiota gut flora gut microbiome gut bacteria gut health gut

shared by Nathan Goodyear on 03 Aug 17 - No Cached
  • Nathan Goodyear on 03 Aug 17
     
    Gestational Diabetes risk may just begin in the gut flora.
Nathan Goodyear

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4430542

antibiotics gut gut bacteria gut flora gut health gut microbiome gut Microbiota diabetes type 1 diabetes

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Gut microbiome and type I diabetes
Nathan Goodyear

BMC Microbiology | Full text | The Firmicutes / Bacteroidetes ratio of the human microb... - 0 views

www.biomedcentral.com/...123

gut flora gut microbiome gut microbiota firmicutes bacteroidetes firmicutes_bacteroidetes health gut microbiome

shared by Nathan Goodyear on 06 May 15 - No Cached
  • The microbiota of the large intestine plays an important role in host metabolism and maintenance of host health
  • Our results defining a standard adult profile, together with previous reports, showed that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
  • Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
  • ...12 more annotations...
  • In infant fecal microbiota, we observed Bifidobacterium as the dominant group
  • this observation is strongly related to diet, being enhanced by breast feeding
  • Significant higher numbers of Bifidobacterium were observed in infants versus adults and seniors
  • the gastrointestinal tract is first colonized by facultative anaerobes, such as E. coli
  • Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
  • diet change must be considered among the primary causes for such a shift of microbiota between infants and adults.
  • In the case of elderly subjects, our qPCR results indicated a significant increase in the counts of E. coli when compared to adults. This data is consistent with other publications indicating that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
  • a number of authors reported a reduction in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
  • The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota status
  • Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those obtained by Ley et al
  • Compared with young adults, the elderly have a different digestive physiology, characterized at a physiological level by a reduction in transit and of digestive secretions
  • The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age
  • Nathan Goodyear on 06 May 15
     
    Good discussion of the gut microbiome.  Age effects the gut bacteria balance.  The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study.  Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
Nathan Goodyear

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, b... - 0 views

www.nature.com/...ncomms15062

brain brain health probiotics antibiotics gut-brain gut bacteria gut flora gut health gut microbiome gut microbiota gut

shared by Nathan Goodyear on 26 Oct 17 - No Cached
  • Nathan Goodyear on 26 Oct 17
     
    Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
Nathan Goodyear

Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? - 0 views

cpa.sagepub.com/...204.abstract

stress PTSD post traumatic stress disorder gut health gut flora gut gut microbiome gut microbiota

shared by Nathan Goodyear on 04 May 16 - No Cached
  • Nathan Goodyear on 04 May 16
     
    Gut microbiome diversity is different in stressed mice and calm mice in animal study.  Authors propose intricate connection between gut:brain and possible evaluation and therapy in PTSD.
Nathan Goodyear

The Placenta Harbors a Unique Microbiome | Science Translational Medicine - 0 views

stm.sciencemag.org/...237ra65.short

placenta pregnancy gut gut bacteria gut flora gut health gut microbiome gut microbiota

shared by Nathan Goodyear on 16 Jun 17 - No Cached
  • Nathan Goodyear on 16 Jun 17
     
    Paradigm shift: placenta is not sterile environment but contains bacteria from mother.  This microbiome may play role in the initiation of the offsprings gut micro biome.
Nathan Goodyear

The Gut Microbiota and Type 1 Diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC4761565

diabetes type I diabetes gut gut flora gut health gut microbiome gut microbiota dysbiosis

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • A study by Bosi and colleagues suggested that the increased gut permeability preceded the clinical onset of T1D
  • gut permeability may be an important player in the development of T1D but, as yet, the findings in human studies have shown association but causation will be more difficult to prove.
  • Early childhood (≤ 3 month) introduction to cereals [10, 11] and cow's milk [48] were shown to promote beta cell autoimmunity
  • ...1 more annotation...
  • These findings suggest that prebiotics and probiotics could be potential therapeutic tools to improve gut integrity in various intestinal inflammatory and autoimmune diseases including T1D
  • Nathan Goodyear on 17 Oct 16
     
    another great review article of gut dysbiosis, altered gut permeability and type I diabetes.
Nathan Goodyear

Population-based metagenomics analysis reveals markers for gut microbiome composition a... - 0 views

science.sciencemag.org/...565

gut flora gut microbiome gut gut health

shared by Nathan Goodyear on 03 May 16 - No Cached
  • Nathan Goodyear on 03 May 16
     
    good review of the effects of the diversity of the gut microbiome.  Only abstracts available here.
Nathan Goodyear

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complica... - 0 views

www.sciencedaily.com/...141125074656.htm

PPIs proton pump inhibitors gut flora gut microbiome gut microbiota gut health biodiversity diversity

shared by Nathan Goodyear on 06 May 15 - No Cached
  • Nathan Goodyear on 06 May 15
     
    Remember those PPIs that you have been taking for years (though the black box label is for 12 weeks)?  Those same PPIs decrease gut microbiome biodiversity.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

estrogen metabolites gut flora gut microbiome gut microbiota hormones cancer breast cancer microbiome estrogen

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.
Nathan Goodyear

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epi... - 0 views

aem.asm.org/...3655.full

gut gut bacteria gut flora gut health gut microbiome gut microbiota akkermansia muciniphila

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • Nathan Goodyear on 11 Jul 17
     
    Akkermansia muciniphila found to increase the integrity of the gut mucosal lining.  Important in gut healing and likely a good biomarker of good/bad gut health and integrity.
Nathan Goodyear

Head-injury profoundly affects gut microbiota homeostasis: results of a pilot study - S... - 0 views

www.sciencedirect.com/...S0899900717301387

TBI traumatic brain injury head injury gut gut bacteria gut flora gut health gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 13 Jul 17 - No Cached
  • Nathan Goodyear on 13 Jul 17
     
    New study finds that head injury alters gut bacteria.  This destroys the isolated systems thinking of traditional medicine.  This is the gut-grain connection, but in REVERSE.
Nathan Goodyear

Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accele... - 0 views

www.ncbi.nlm.nih.gov/...26274050

diabetes type I diabetes gut gut bacteria gut flora gut health gut microbiome gut Microbiota diabetogenic microbiome probiotic antibiotics

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Only abstract available here.  Animal study finds that gut bacteria induce diabetes and early antibiotic exposure accelerated this autoimmune activity.  This study also used VSL#3 to attempt to treat but no effect was evident.  
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