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Nathan Goodyear

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, b... - 0 views

www.nature.com/...ncomms15062

brain brain health probiotics antibiotics gut-brain gut bacteria gut flora gut health gut microbiome gut microbiota gut

shared by Nathan Goodyear on 26 Oct 17 - No Cached
  • Nathan Goodyear on 26 Oct 17
     
    Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
Nathan Goodyear

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Agg... - 0 views

www.nature.com/srep34477

neurodegenerative disease amyloid alzheimer's disease Parkinson's disease gut gut flora gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 06 Oct 16 - No Cached
  • Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
  • Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
  • Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
  • ...8 more annotations...
  • changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
  • Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
  • exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
  • AS aggregates seed aggregation of tau
  • involvement of the vagus nerve in PD
  • microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
  • the immune system in both AD and PD have now been extensively established
  • TLR2 activation through exposure to bacterial amyloid is pathogenic
  • Nathan Goodyear on 06 Oct 16
     
    Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease.  These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain.   More establishment of the gut-brain connection.  
Nathan Goodyear

Gut-brain link grabs neuroscientists : Nature News & Comment - 0 views

www.nature.com/...-grabs-neuroscientists-1.16316

gut flora gut gut microbiome gut microbiota gut-brain autism

shared by Nathan Goodyear on 29 Jun 15 - No Cached
  • Nathan Goodyear on 29 Jun 15
     
    Gut-brain connection via gut microbiome starts to move mainstream.
Nathan Goodyear

Head-injury profoundly affects gut microbiota homeostasis: results of a pilot study - S... - 0 views

www.sciencedirect.com/...S0899900717301387

TBI traumatic brain injury head injury gut gut bacteria gut flora gut health gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 13 Jul 17 - No Cached
  • Nathan Goodyear on 13 Jul 17
     
    New study finds that head injury alters gut bacteria.  This destroys the isolated systems thinking of traditional medicine.  This is the gut-grain connection, but in REVERSE.
Nathan Goodyear

PLOS ONE: The Gut Microbiota and Developmental Programming of the Testis in Mice - 0 views

journals.plos.org/...article

hormone hormones Testosterone gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
  • This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
  • Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
  • ...8 more annotations...
  • Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
  • he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
  • Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
  • In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
  • the absence of gut microbiota influenced testosterone levels
  • A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
  • bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
  • This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
  • Nathan Goodyear on 30 Apr 15
     
    gut micro biome effects spermatogenesis, Testosterone production, and the brain-testicle-barrier.
Nathan Goodyear

The role of gut microbiota in the gut-brain axis: current challenges and perspectives. ... - 0 views

www.researchgate.net/...nt_challenges_and_perspectives

gut brain microbiota dysbiosis gut-brain axis

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Great discussion of the gut brain connection.
Nathan Goodyear

Relationships between diet-related changes in the gut microbiome and cognitive flexibility - 0 views

www.sciencedirect.com/...S0306452215004480

gut gut flora gut microbiome gut microbiota gut-brain sugar diet nutrition learning memory

shared by Nathan Goodyear on 29 Jun 15 - No Cached
  • Nathan Goodyear on 29 Jun 15
     
    High dietary sugar intake alters gut bacteria (increased Clostridia sp. and decrease Bacteroidetes sp).  This resulted in decreased memory learning and memory in rat study.  
Nathan Goodyear

The Effect of Microbiota and the Immune System on the Development and Organization of t... - 0 views

www.gastrojournal.org/...fulltext

ENS enteric nervous system gut gut health gut bacteria gut microbiome gut-brain brain Parkinson's disease nervous system

shared by Nathan Goodyear on 30 Nov 16 - No Cached
  • Nathan Goodyear on 30 Nov 16
     
    great read on the enteric nervous system and it interaction with the host immune system and the brain.
Nathan Goodyear

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome... - 0 views

www.nature.com/...nature18309.html

gut gut microbiome gut microbiota gut-brain obesity insulin gherlin acetate

shared by Nathan Goodyear on 13 Jun 16 - No Cached
  • Nathan Goodyear on 13 Jun 16
     
    New study proposes how altered gut microbiota leads to obesity.  The short answer is increased insulin production, increased gherlin, and older studies suggest inflammation also.
Nathan Goodyear

Think Twice: How the Gut's "Second Brain" Influences Mood and Well-Being: Scientific Am... - 0 views

www.scientificamerican.com/article.cfm

gut second brain wellness health well-being mood

shared by Nathan Goodyear on 24 Aug 11 - No Cached
  • Nathan Goodyear on 24 Aug 11
     
    So goes your gut, so goes your brain and mood
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https://www.thefastleanpro.us/ - 0 views

www.thefastleanpro.us

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
Nathan Goodyear

Think Twice: How the Gut's "Second Brain" Influences Mood and Well-Being: Scientific Am... - 0 views

www.scientificamerican.com/article.cfm

Gut GI system mood depression anxiety

shared by Nathan Goodyear on 25 May 11 - Cached
  • Nathan Goodyear on 25 May 11
     
    Gut: as a second brain?  
Nathan Goodyear

short-term benefit from oral vancomycin treatment of regressive-onset autism - 0 views

www.ncbi.nlm.nih.gov/pubmed

autism ASD dysbiosis inflammation gut GI gastrointestinal children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism
Nathan Goodyear

Frontiers | Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of... - 0 views

journal.frontiersin.org/...full

LPS lipopolysaccharides Alzheimer's disease brain inflammation

shared by Nathan Goodyear on 23 Sep 17 - No Cached
  • lipopolysaccharides (LPS), either alone or in combination, have indicated that when compared, bacterial LPSs exhibit the strongest induction of pro-inflammatory signaling in human neuronal–glial cells in primary coculture of any single inducer, and different LPS extracts from different gastrointestinal (GI)-tract resident Gram-negative bacteria appeared to have different pro-inflammatory potential
  • powerful inducer of the NF-κB
  • In both neocortex and hippocampus, LPS has been detected to range from a ~7- to ~21-fold increase abundance in AD brain
  • ...15 more annotations...
  • Major Gram-negative bacilli of the human GI-tract, such as the abundant B. fragilis and Escherichia coli (E. coli), are capable of discharging a remarkably complex assortment of pro-inflammatory neurotoxins
  • (i) bacterial amyloids (10, 21); (ii) endotoxins and exotoxins (5, 12); (iii) LPS (12, 18); and (iv) small non-coding RNAs (sncRNAs)
  • integral components of the outer leaflet of the outer membrane of Gram-negative bacteria, LPS
  • LPS, the major molecular component of the outer membrane of Gram-negative bacteria normally serves as a physical barrier providing the bacteria protection from its surroundings
  • LPS is also recognized by the immune system as a marker for the detection of bacterial pathogen invasion and responsible for the development of inflammatory response is perhaps the most potent stimulator and trigger of inflammation known
  • AD-affected brains have remarkably large loads of bacterial-derived toxins compared to controls. The transfer of noxious, pro-inflammatory molecules from the GI-tract microbiome to the CNS may be increasingly important during the course of aging when both the GI-tract and blood–brain barriers become significantly more permeable
  • first evidence of a perinuclear association of LPS with AD brain cell nuclei
  • LPS-mediated stimulation of chronic inflammation, beta-amyloid accumulation, and episodic memory decline in murine models of AD (39, 40) and a biophysical association of LPS with amyloid deposits and blood vessels in human AD patients
  • Strong adherence of LPS to the nuclear periphery has recently been shown to inhibit nuclear maturation and function that may impair or block export of mRNA signals from brain cell nuclei, a highly active organelle with extremely high rates of transcription, mRNA processing, and export into the cytoplasm
  • LPS may be further injurious to the nuclear membrane just as LPS contributes to cerebrovascular endothelial cell membrane injury
  • high intake of dietary fiber is a strong inhibitor of B. fragilis abundance and proliferation in the intact human GI-tract and as such is a potent inhibitor of the neurotoxic B. fragilis-derived amyloids, LPS, enterotoxins, and sncRNAs.
  • GI-tract microbiome-derived LPS may be an important initiator and/or significant contributor to inflammatory degeneration in the AD CNS
  • LPS has been recently localized to the same anatomical regions involved in AD-type neuropathology
  • a known pro-inflammatory transcription factor complex that triggers the expression of pathogenic pathways involved in neurodegenerative inflammation
  • pro-inflammatory amyloids, endo- and exotoxins, LPSs, and sncRNAs but also serve as potent sources of membrane-disrupting agents
  • Nathan Goodyear on 23 Sep 17
     
    LPS links gut to inflammation in Alzheimer's disease
Nathan Goodyear

Normal gut microbiota modulates brain development and behavior - 0 views

www.pnas.org/...3047.abstract

gut brain development behavior balance gastrointestinal dysbiosis

shared by Nathan Goodyear on 29 Jun 11 - No Cached
  • Nathan Goodyear on 29 Jun 11
     
    mice model study that shows how gut bacterial balance can alter neurochemistry and cause behavior/developmental changes
Nathan Goodyear

Brain foods: the effects of nutrients on brain function - 0 views

www.ncbi.nlm.nih.gov/...PMC2805706

brain food nutrition cognition

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Just a great article on the interaction between food, gut and the brain.
Nathan Goodyear

Malabsorption and cerebral dysfunction: A multivariate and comparative study of autisti... - 0 views

www.springerlink.com/...l1501v2578535741

autism ASD gut brain gastrointestinal gluten inflammation children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    Study all the way back from 1971 suggesting link between the gut and brain in children with autism. They suggested a malabsorptive and inflammatory response to gluten.
Nathan Goodyear

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and... - 0 views

www.gastrojournal.org/...abstract

behavior Gut intestinal microbiota anxiety mood depression

shared by Nathan Goodyear on 25 May 11 - No Cached
  • Nathan Goodyear on 25 May 11
     
    Gut and Brain linked together
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