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Nathan Goodyear

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging - 0 views

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    SIRT1, known to reduce inflammatory signaling, found to help maintain circadian rhythm.  Loss of the circadian rhythm is know to contribute to chronic disease.  Likewise, SIRT1 has been shown to reduce inflammation, which will reduce disease.  Is this their link?
Nathan Goodyear

Effect of a phase advance and phase delay of ... [Am J Clin Nutr. 2012] - PubMed - NCBI - 0 views

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    small study. But it showed that disruption in circadian rhythm results in disruption of insulin/glucose metabolism.
Nathan Goodyear

Circadian Rhythm Disruption Promotes Lung Tumorigenesis: Cell Metabolism - 0 views

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    A proposed mechanism of how night shift work is a carcinogen.
Nathan Goodyear

Validation of a cortisol enzyme immunoassay and characterization of salivary cortisol c... - 0 views

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    granted, this comes from the American Journal of Primatology; but their conclusion says it all: "we recommend that saliva collection may be the moste effective method of measuring stress reactivity and as the potential to complement behavioral, cognitive, physiologic, and welfare studies".
Nathan Goodyear

Circadian variation in salivary testosterone across age classes in Ache Amerindian male... - 0 views

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    this article looked at normal testosterone rhythm  via saliva.  Normal testosterone peaks in am and is lowest in pm. The normal testosterone rhythm decreases as a man ages.  This is similar results as seen in serum.
Nathan Goodyear

Circadian disruption in cancer: a neuroend... [Brain Behav Immun. 2003] - PubMed - NCBI - 0 views

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    disrupted cortisol rhythm or pattern due to stress is a pathway to disease.  A disrupted HPA axis is a disrupted immune system.
Nathan Goodyear

Establishing circadian rhythm profiles for salivary testosterone in women: evidence of ... - 0 views

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    salivary testosterone found to decline in women beyond the age of 39 with many women > 50 with low salivary testosterone levels.
Nathan Goodyear

Out-Patient Screening for Cushing's Syndrome: The Sensitivity of the Combination of Cir... - 0 views

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    salivary cortisol recommended for evaluating Cushing's syndrom
Nathan Goodyear

Melatonin and Cortisol assessment of circadian shifts in astronauts before flight - Whi... - 0 views

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    Melatonin and Cortisol salivary testing by NASA
Nathan Goodyear

Monitoring the circadian rhythm of se... [Domest Anim Endocrinol. 2013] - PubMed - NCBI - 0 views

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    Animal study finds very good correlation of salivary cortisol and free plasma cortisol.
Nathan Goodyear

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbi... - 0 views

  • a lack of microbiota results in a permanent ileal overproduction of corticosterone due to decreased expression of the D-box-binding E4BP4 repressor. This hypercorticosterolism generates systemic metabolic defects (hyperglycemia, insulin resistance, increased TG and FA)
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    to be read article on the communication between gut microbiota and intestinal epithelial cells and the resultant metabolic impact.
Nathan Goodyear

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Me... - 0 views

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    dopamine inhibits melatonin production and release disrupting sleep.
Nathan Goodyear

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to ... - 0 views

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    Sleep deprivation, defined as 1 night of no sleep, changed epigenetic expression of BMAL via increased methylation. Other findings: decreased cortisol, increased glucose...
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