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Nathan Goodyear

The significance of proinflammatory cytokines and Th1/ Th2 balance in depression and ac... - 1 views

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    good review of the interatction between inflammation and depression and then the interaction between anti-depressants and inflammation
Nathan Goodyear

Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study: T... - 0 views

  • bioavailable testosterone levels decrease much more with age than does total testosterone or estradiol levels
  • The decrease in bioavailable testosterone parallels the increase in sex hormone binding globulin with age, a change that accompanies increasing body fat independent of weight change
  • a graded stepwise decrease in bioavailable testosterone with increasing level of depressed mood
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  • This association was independent of age, weight change, and physical activity, the only three significant confounding covariates of the association between sex hormone levels and BDI scores
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    bioavailable Testosterone is inversely associated with increased depressive symptoms.
Nathan Goodyear

Testosterone Gel Supplementation for Men With Refractory Depression: A Randomized, Plac... - 0 views

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    study that looked at men with refractory depression symptoms on depression meds with low Testosterone finds Testosterone therapy improved depression symptoms.
Nathan Goodyear

Comparative efficacy and tolerability of antidepressants for major depressive disorder ... - 0 views

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    could the anti-depressant industry in children and adolescents be a scam?  A review of the evidence finds very low quality of evidence with > 56% of the studies being funded by the industry itself; can you say conflict of interest or potential bias?  Review finds evidence only that fluoxetine is more effective than placebo in children and adolescents with depression.
Nathan Goodyear

Depression, antidepressant medications, and risk of Clostridium difficileinfection | BM... - 0 views

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    PPI therapies, histamine (specifically type II) antagonists and antidepressants are associated with clostridium difficile infection. 
Nathan Goodyear

Light Therapy More Effective Than Prozac in Patients With Major Depression | Natural Me... - 0 views

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    new study finds that light therapy therapy for major depression outperformed prozac therapy.  This study was short at only 8 weeks.
Nathan Goodyear

Prospective longitudinal study of testosterone and incident depression in older men: Th... - 0 views

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    low Total Testosterone is associated with depression in oder men.
Nathan Goodyear

Efficacy and Safety of Curcumin in Major Depre... [Phytother Res. 2013] - PubMed - NCBI - 0 views

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    curcumin found to be statistically similar to fluoxetine in depression;  In combination there is an adjuvant effect to increase the efficacy.
Nathan Goodyear

Sexual dysfunction in males with chronic hepatitis C and antiviral therapy: interferon-... - 0 views

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    Study of men with hepatitis C and interferon therapy found decrease in free and total Testosterone levels in men.  The study results suggest a non-HPA effect, which suggests more of a peripheral effect at the level of the TEsticles.
Nathan Goodyear

Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and... - 0 views

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    Optimal Selenium levels associated with lower incidence of depressive moods--link to optimal glutathione pathways?  
Nathan Goodyear

Cognitive effects of testosterone and finasteride administration in older hypogonadal men - 0 views

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    Testosterone found to provide small improvement in depression in men > 60 and starting serum Testosterone levels < 300.  Small improvement in cognition also noted.  
Nathan Goodyear

The association between erectile dysfu... [Scand J Public Health. 2014] - PubMed - NCBI - 0 views

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    Finnish study found no association between free Testosterone and Total Testosterone, and ED.
Nathan Goodyear

Sex-specific effects of long-term exposure to bi... [Chemosphere. 2014] - PubMed - NCBI - 0 views

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    really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice.

    Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.
Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

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    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
Nathan Goodyear

Gonadal hormone levels and platelet tryptophan and serotonin concentrations in perimeno... - 0 views

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    Interesting: study finds no association between tryptophan and serotonin levels and depression.  The study found no difference between 44 "depressed" perimenopausal women and 19 "without depression".  Serotonin therapy of depression??  However, poor sleep and hot flashes did.
Nathan Goodyear

ROUND-UP: Predicting depression in boys (PNAS*) - an expert responds - AusSMC - Austral... - 0 views

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    Elevated salivary am cortisol predicts increased risk of depression in boys.  
Nathan Goodyear

JAMA Network | JAMA Psychiatry | Mineralocorticoid Receptor Function in Major Depression - 0 views

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    High cortisol reduce 5-HT1A receptors in major depression.
Nathan Goodyear

Depression and cortisol responses to psychological stress: A meta-analysis - 0 views

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    Depression found to have higher cortisol levels compared to non-depressed men and women.
Nathan Goodyear

Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations ... - 0 views

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    Elevated morning cortisol associated with depression in men. This study looked at saliva for assessment of free cortisol.
Nathan Goodyear

One year follow-up study of the association between chemical castration, sex hormones, ... - 0 views

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    Chemical castration as seen in androgen deprivation therapy resulted in precipitous decline in Testosterone and Estradiol in men.  Associated increased in beta-amylloid found.
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