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Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

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    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
Nathan Goodyear

Gonadal hormone levels and platelet tryptophan and serotonin concentrations in perimeno... - 0 views

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    Interesting: study finds no association between tryptophan and serotonin levels and depression.  The study found no difference between 44 "depressed" perimenopausal women and 19 "without depression".  Serotonin therapy of depression??  However, poor sleep and hot flashes did.
Nathan Goodyear

ROUND-UP: Predicting depression in boys (PNAS*) - an expert responds - AusSMC - Austral... - 0 views

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    Elevated salivary am cortisol predicts increased risk of depression in boys.  
Nathan Goodyear

JAMA Network | JAMA Psychiatry | Mineralocorticoid Receptor Function in Major Depression - 0 views

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    High cortisol reduce 5-HT1A receptors in major depression.
Nathan Goodyear

Depression and cortisol responses to psychological stress: A meta-analysis - 0 views

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    Depression found to have higher cortisol levels compared to non-depressed men and women.
Nathan Goodyear

Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations ... - 0 views

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    Elevated morning cortisol associated with depression in men. This study looked at saliva for assessment of free cortisol.
Nathan Goodyear

One year follow-up study of the association between chemical castration, sex hormones, ... - 0 views

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    Chemical castration as seen in androgen deprivation therapy resulted in precipitous decline in Testosterone and Estradiol in men.  Associated increased in beta-amylloid found.
Nathan Goodyear

Depression in Men Receiving Androgen Deprivation Therapy for Prostate Cancer: A Pilot S... - 0 views

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    Significantly higher rates of depression in men with prostate cancer receiving ADT versus the general population.
Nathan Goodyear

Roles of the gonadal steroid hormones in psychiatric depression in men and women - Rese... - 0 views

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    Fascinating difference in the sexes.  High estradiol is found to be associated with depression in men and high Testosterone is found to be associated with depression in women.  The exact mechanism or strength of association is unstated.
Nathan Goodyear

Low-Dose Transdermal Testosterone Therapy Improves Angina Threshold in Men With Chronic... - 0 views

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    Small study finds low dose Testosterone, 5 mg over 12 weeks, reduced exercise induce myocardial ischemia through an increase in time to ST segment depression.
Nathan Goodyear

Testosterone Levels and Sexual Function Disorders ... [J Sex Med. 2013] - PubMed - NCBI - 0 views

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    Interesting finding in this study. They looked at Total Testosterone and bioavailable Testosterone and found that antidepressant therapy increased both values post treatment.  This is counter to what has been readably seen in men--with a decline.  The abstract here does not point disclose the actual Testosterone numbers.  I wonder if the well known disruption of the CYP enzymes by antidepressants slowed clearance and increased Testosterone levels.  This study did not look at other hormones or inflammatory cytokines.  Very tunneled vision study.  Nothing can be drawn from this study.
Nathan Goodyear

Natural polyphenols in the management of major depression, Expert Opinion on Investigat... - 0 views

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    Abstract only available, shows that polyphenols useful in the treatment of depression.
Nathan Goodyear

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction ... - 0 views

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    rat model finds fast, long-lasting benefit of acetyl carnitine in depression.
Nathan Goodyear

Study Finds Estrogen Therapy Improves Depression and Anxiety in Recently Menopausal Wom... - 0 views

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    Estrogen therapy in women recently postmenopausal, found to improve symptoms of depression and anxiety.  The mean age of women in this study was 52.7.  Average age of menopause is 51, so apprx 1 year postmenopausal in this study.  Both premarin and bioidentical estradiol was used in different arms of the study.  Bioidentical progesterone was used in all 3 arms.
Nathan Goodyear

Tryptophan-Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impa... - 0 views

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    Disordered tryptophan metabolism in depression
Nathan Goodyear

Efficacy and Safety of Curcumin in Major Depre... [Phytother Res. 2013] - PubMed - NCBI - 0 views

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    Study finds that curcumin alone is better than Prozac for Major depression.  Though not statistically significant, the response rate as determined by the Hamilton Depression scale favored curcumin above that of Prozac.  The effective dose was 1000 mg in this study.  The combination also provided additional benefit above that of prozac alone.
Nathan Goodyear

Salivary cortisol levels and the 2-... [Psychoneuroendocrinology. 2013] - PubMed - NCBI - 0 views

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    This study projected that lower am cortisol in those with long standing depression/anxiety have a more negative long-term prognosis.
Nathan Goodyear

The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

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    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
Nathan Goodyear

Heart-brain medicine: Update 2008 - 0 views

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    It does appear that medicine is moving in the direction of a non-linear approach to disease.  This brief review discusses the early analysis of the relationship of psychiatric conditions, inflammation, and cardiovascular disease.
Nathan Goodyear

Effect of vitamin D supplement on depression scores in people with low levels of serum ... - 0 views

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    Low vitamin D levels associated with more depression; However, vitamin D3 treatment did not improve depression symptoms.
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