This study found a 2 fold increased in estradiol levels in rats exposed to phthalates in-utero. This could have been due to increased aromatase activity and/or xenoestrogenic effect. This study proposes a link between phthalate exposure in-uteruo, increased estrogen production and testicular dysgenesis syndrome. Take home: in this model male testicles were altered prior to birth by phthalate exposure.
Interesting rat model finds that stimulation of the leydig cells of the testis by LH induces ROS. May be one of the mechanisms by which androgen therapy will induce long-term requirement for replacement.
animal model, but Bisphenol A shown to increase aromatase production. This aids the decreased T:E2 ratio that is commonly found in prostate disease. So, BPA is a xenoestrogen. BPA is an androgen receptor antagonist and BPA increases aromatase activity.
Rat model induced inflammatory reaction in brain via LPS injection. The result was impaired memory. RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
RG3, an extract from panax ginseng, found to protect against the neurotoxin acrylamide.
Also of interest, is that serotonin, corticosterone, T3, T4, estradiol, progesterone and epinephrine were all decreased in this acrylamide rat model.
Very interesting article. Early Progesterone treatment, in animal model, shown to improve neuropathic pain recovery. This is by no means the first study to show this. This has been shown numerous times in TBI, but the timing of therapy was the purpose of this article. What is very interesting here is that the metabolites implicated here in the recovery are the same metabolites implicated in an increased tumor potential.
Mepro-ipl have finally launched the latest model online of our Homedics Me PRO Ultra . Finally a machine for absolutely all skin tones and [ALL body ALL skin type] Permanent Infra-red Light [IPL] Laser Radio Frequency.
A little research can ensure informed selections when deciding to purchase infusion pumps. The more you know about these medical devices, the easier it becomes to choose the exact model and type you require.
In rat model, Pb reduced NO and contributed to ED. Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.
Only abstract available here. The authors of the this epidemiologic article estimate that 58,000 cases of breast cancer and 49,000 cases of colorectal cancer can be prevented annually by raising levels to 40-60. The study also points to a new cancer model that Vitamin D has a positive effect at each step. The acronym is DINOMIT and this stands for disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition.
Animal model found that low Hg decreased NO availability. The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system. The importance here is that low Hg levels induced this change.
Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model. Hg has been shown to both inhibit NO synthase and increase COX.