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Nathan Goodyear

The molecular basis of neurodegeneration in multiple sclerosis - 0 views

  • Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
  • in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
  • anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
  • ...1 more annotation...
  • Inflammation will remain a key target, since the data suggest that microglia activation and oxidative burst is driven by inflammation throughout all stages of the disease.
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    Very nice review of the neurodegenerative process in MS.  
Nathan Goodyear

Vitamin D in the healthy and inflamed central nervous system: access and function - 0 views

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    Vitamin D3 helpful in treatment of an inflamed CNS, such as in TBI, MS...Vitamin D protects against the development of MS and the progression of MS.
Nathan Goodyear

Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Sy... - 0 views

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    Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model.  This occurs through activation of calcium channels and influx of calcium.  ER alpha appears to be the prominent ER involved.
Nathan Goodyear

Central nervous system disease in patients with macrop... [Brain. 2001] - PubMed - NCBI - 0 views

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    Macrophagic myofasciitis and CNS disease. This study describes disease that mimics MS as a result of aluminum.
Nathan Goodyear

Lead exposure, polymorphisms in genes related to oxidative stress and risk of adult bra... - 0 views

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    another study that showed that lead exposure in susceptible individuals increased risk of CNS tumors, including menngiomas, and gliomas.  The apparent mechanism in this study was proposed through oxidative damage.  
Nathan Goodyear

Lead, Genetic Susceptibility, and Risk of Adult Brain Tumors - 0 views

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    this study suggests that Pb exposure, in those with ALAD polymorphism, have an increased risk of meningioma.
Nathan Goodyear

Understanding the Direct Synaptic Effects of Estradiol - 0 views

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    commentary on the current state of knowledge of estrogen receptors, particularily ER alpha, and brain synapsis.
Nathan Goodyear

International Journal of Obesity - Late-life obesity is associated with smaller global ... - 0 views

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    Need your brain at its peak performance?  Better lose weight if you are overweight.  Studies show a reduced brain volume and decreased cognitive function in those that are overweight.
Nathan Goodyear

ScienceDirect.com - Frontiers in Neuroendocrinology - Progesterone receptors: Form and ... - 0 views

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    progesterone through progesterone receptors, shown to have protective, anti-inflammatory effects in the CNS.
Nathan Goodyear

Oxidative stress and neurodegeneration: where are we now? - Halliwell - 2006 - Journal ... - 0 views

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    Fantastic review of oxidative damage and the CNS.  This is a 2006 review of our understanding of how neurodegeneration occurs through oxidative stress and of course poor detoxification.
Nathan Goodyear

A radical approach to stroke therapy - 0 views

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    vitamin C shown to benefit stroke patients.  Vitamin C, ascorbic acid, is extremely prevalent in the brain.  Functions to scavenge free radicals
Nathan Goodyear

Central Nervous system control of food intake - 0 views

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    For you biochemistry junkies. A great review of how the Gut and CNS communicate to regulate food intake
Nathan Goodyear

Progesterone exerts neuroprotective effects after brain injury 10.1016/j.brainresrev.20... - 0 views

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    progesterone shown to have neuroprotective and  healing properties in the CNS.  This has implications in Stroke, and possibly even excitotoxic disease such as Parkinson's, Alzhemier's...
Nathan Goodyear

Activation of CNS Inflammatory Pathways by Interferon-alpha: Relationship to Monoamines... - 0 views

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    mechanism of peripheral inflammation , via IFN-alpha and IL-6, contribution to depression
Nathan Goodyear

Access : Central nervous system control of food intake : Nature - 0 views

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    great review on CNS regulation of food intake
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