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Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response i... - 0 views

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    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

Obesity-induced hypogonadism in the male: Prem... [Endocrinology. 2014] - PubMed - NCBI - 0 views

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    High fat diet decrease hypothalamic kisspeptin levels result in decreased GNRH release.  The result is a decrease in LH/FSH and in this case decreased Testosterone.  These were animal models.
Nathan Goodyear

Polysaccharides from Cordyceps sinensis mycelium ... [Pharm Biol. 2014] - PubMed - NCBI - 0 views

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    Mouse model finds that Cordyceps increased the interval to exhaustive exercise induced oxidative stress.  SOD, Cat, and GPx were increased in the low, intermediate, and high dose Cordyceps groups.  Oxidative stress markers MDA and 8-OHdG were lower in all groups
Nathan Goodyear

In vivo and in vitro stimulatory effects of Cordyce... [Life Sci. 2003] - PubMed - NCBI - 0 views

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    Cordyceps increased Testosterone production in mouse model.
Nathan Goodyear

Effect of Cordyceps militaris supplementation ... [Am J Chin Med. 2008] - PubMed - NCBI - 0 views

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    Cordyceps increased Testosterone, Estradiol, sperm count and motility in mouse model.
Nathan Goodyear

World J Gastroenterol - 0 views

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    Animal model finds glycine reduces liver damage.
Nathan Goodyear

Testosterone therapy delays cardiomyocyt... [Braz J Med Biol Res. 2011] - PubMed - NCBI - 0 views

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    Study finds that low Testosterone contributes to cardiomyocyte agine in mouse model.  Low Testosterone was associated with a shorter telomere length.  "Physiologic" Testosterone therapy slowed this aging effect of the cardiomyocyte via an AR independent pathway as the Tfm mice have nonfunctional AR.  The authors propose that it may be via aromatase activity.
Nathan Goodyear

Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Sy... - 0 views

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    Estradiol stimulates hypothalamic progesterone synthesis in astrocytes in rat model.  This occurs through activation of calcium channels and influx of calcium.  ER alpha appears to be the prominent ER involved.
Nathan Goodyear

Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecules in the A... - 0 views

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    Testosterone modulates dopaminergic pathways in the the brain.  This was a rat model.  This points to some of the euphoria experienced by men on Testosterone likely occurs through dopamine.
Nathan Goodyear

Estriol treatment ameliorates disease in male... [J Neuroimmunol. 2004] - PubMed - NCBI - 0 views

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    Estriol found to be beneficial in experimental model of MS called EAE.  The effect would be through E3's preferential binding to ERbeta.  This study finds benefit in men and women.
Nathan Goodyear

Harriet Lane Handbook: Progesterone regulates the phosphorylation of protein phosphatas... - 0 views

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    rat model finds that progesterone effects internal cell enzyme activity.  In this case, progesterone increased PP2A in the cerebellum and in the hyippocampus.  Interesting, that E2 priming decreased the effects on the hippocampus, but not the cerebellum.  This reveals a biochemical link between sex hormones, progesterone in this case, and the brain.  Studies have shown progesterone to be neuroprotective in TBI.  This may be one mechanism.
Nathan Goodyear

Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two ... - 0 views

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    Low dose estrogen therapy to reduce autoinflammatory T cells in rat model with autoimmune encephalomyelitis.
Nathan Goodyear

HPA axis changes during the initial phase of psychosocial stressor exposure in male mice - 0 views

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    Stress response in a animal model is blunted at the level of pituitary through a decrease in ACTH release and through increase in peripheral metabolism
Nathan Goodyear

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyel... - 0 views

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    DHEA found to decrease IFN-gamma, IL-12, and TNF-alpha through inhibition of NF-kappaB in animal model of MS.
Nathan Goodyear

[Effect of intravenous im... [Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008] - PubMed - NCBI - 0 views

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    IV vitamin C plus IVIG is more effective at reducing TNF alpha in autoimmune disease model known as experimental autoimmune myocarditis.
Nathan Goodyear

BMC Cancer | Full text | Estradiol suppresses tissue androgens and prostate cancer grow... - 0 views

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    Mice model finds that estradiol reduces tumor growth in castrated mice.  This mechanism occurred in an ER independent manner.  This was in the presence of low androgen levels.  This is in contrast to aromatase activity and ER. 
Nathan Goodyear

Efficacy and mechanism of action of turmeric supplements in the treatment of experiment... - 0 views

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    Tumeric inhibits NF-KappaB and thus inflammation in arthritis model.
Nathan Goodyear

Influence of alpha-lipoic acid on lipid ... [Diabetes Obes Metab. 2004] - PubMed - NCBI - 0 views

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    Numerous deletorious effects are seen in high fructose diets: elevated Triglyceride production, fatty liver, insulin resistance, increased VLDL production and secretion, increased deposit of TG in muscle and increased muscle insulin resistance.  Alpha lipoic Acid is shown to counter these effects in rat model.
Nathan Goodyear

Curcumin attenuates aluminum-induced oxidative ... [Neurotox Res. 2011] - PubMed - NCBI - 0 views

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    Curcumin shown to inhibit oxidative stress, inflammation, and mitochondrial damage caused by Aluminum in rat brain.  Aluminum's effect is not just confined to rat models.  It is well known to cause similar results in the human brain as well.  what is interesting about this article is the clear pathway disruption described as a result of Aluminum exposure.
Nathan Goodyear

Aluminum and copper in drinking water enhance... [J Neuroimmunol. 2006] - PubMed - NCBI - 0 views

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    Aluminum and Copper individually increase brain inflammation, but this study found synergistic effect on inflammation.  This test was in a mouse model using a 3 month introduction of contaminated water.
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