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Very interesting article.  Early Progesterone treatment, in animal model, shown to improve neuropathic pain recovery.  This is by no means the first study to show this.  This has been shown numerous times in TBI, but the timing of therapy was the purpose of this article.  What is very interesting here is that the metabolites implicated here in the recovery are the same metabolites implicated in an increased tumor potential.

low dose naltrexone plus opiate therapy improves neuropathic pain

Another study finds progesterone prevents neuropathic pain in animal model; timing is everything.

IV vitamin C therapy found to be beneficial in aiding neuropathic pain from postherpetic neuralgia.

alpha lipoic acid shown to reduce diabetic neuropathy in this review of 15 clinical trials.  The trials included both IV and oral administration of alpha lipoic acid.  Both routes of administration revealed positive reduction of neuropathic symptoms.

Progesterone shown to improve neuropathy in animal model.

alpha Lipoic Acid improves Diabetic Neuropathy

Great article.  Really shows the depth of the androgens and androgen metabolites in diabetes and diabetic complications.  In this study, DHT and its metabolis 3-alpha androstanediol were shown to reduce inflammation and pain associated with diabetic neuropathy.  Significant reduction in inflammation signaling (IL-1beta, TNF-alpha) was seen as was potential neurodegenerative processes (glutamate release and astrocyte immunoreactivity).

Animal study finds that CBD reduces chemotherapy induced neuropathy and pain.

Magnesium threonate useful in reducing TNF-alpha  and improve memory in animal model.  Magnesium threonate crosses the BBB well.

10 mg/kg in males and 15 mg/kg in females without side effects