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Nathan Goodyear

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ... - 0 views

  • glioblastoma‐initiating cells (GICs)
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    prazosin promotes apoptosis of gliobastoma-initiating cells in mouse model via Akt pathway.
Nathan Goodyear

Hypertension as a biomarker in patients with recurrent glioblastoma treated with antian... - 0 views

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    treatment with anti-angiogenesis meds often are associated with the SE of HTN; What is interesting about this is that this is associated with improved survival.
Nathan Goodyear

Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

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    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
Nathan Goodyear

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use | Annals of Inter... - 0 views

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    IV vitamin C found to significantly increased serum levels beyond that of oral.  IV vitamin C is the only route that should be administered for patients with cancer.  IVC at 50 grams showed peak C concentration at 13,400 micromol/L.  Levels of at least 400-600 are required for tumorcidal effects.  In addition, IV vitamin C increased NO release and decreases b/p
Nathan Goodyear

Ascorbic Acid-Induced Modulation of Venous Tone in Humans | Hypertension - 0 views

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    Acute vasodilation with IV vitamin C found to be independent of NO.
Nathan Goodyear

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activit... - 0 views

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    IV Vitamin C improves endothelial vasodilation in essential hypertension.  The Vitamin C reduces the oxygen free radicals which allowed eNOS to increase NO production.  Two take homes: oxygen free radicals may be responsible for the endothelial dysfunction that leads to essential hypertension and vitamin C, particularly IV, can be used to counter this process.  Other studies have shown IV vitamin C to be anti-hypertensive in its action.
Nathan Goodyear

https://www.researchgate.net/profile/Osama_Arafat/publication/234135338_METHYLCOBALAMIN... - 0 views

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    Animal study points to methylB12 as the cause of an increase in adrenal medulla norepinephrine production.  This has significant implications in individuals with hypertension.
Nathan Goodyear

Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metab... - 0 views

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    Review article finds evidenc that Mediterranean diet alters epigenetic expression of child during pregnancy to reduce metabolic syndrome risk.
Nathan Goodyear

Thiazide Diuretics Alone or with Beta-blockers Impair Glucose Metabolism in Hypertensiv... - 0 views

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    thiazide diuretics and beta blockers impair glucose metabolism; mechanism of action not exactly known.
Nathan Goodyear

Vegetarian Diets and Blood Pressure: Meta-analysis | Cardiology | JAMA Internal Medicin... - 0 views

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    vegetarian diet lowers blood pressure by 4.8 mmHg to 6.9 mmHg in meta-analysis.
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
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  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
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    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
Nathan Goodyear

In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk p... - 0 views

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    Diet is a language that interacts with out DNA.  Study finds that Mediterranean diet + extra virgin olive oil alters genetic expression to reduce cardiovascular risk.
Nathan Goodyear

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activit... - 0 views

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    vitamin C, in small study in patient with/without hypertension, found to increase endothelial vasodilation via increasing eNOS activity.
Nathan Goodyear

Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized c... - 0 views

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    review article of 29 studies finds a reduction in blood pressure with vitamin C.  The average dosing of vitamin C was 500 mg, which is a woefully inadequate dose.  The average study follow up was 8 weeks.
Nathan Goodyear

Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes | Hypert... - 0 views

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    Study finds a nominal dose of vitamin C, 500 mg/day, decreased blood pressure and arterial stiffness in diabetics after only 1 month.  Imagine what you can do with therapeutic levels?
Nathan Goodyear

Blood Pressure Effects of Vitamin C | Hypertension - 0 views

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    review article of studies on vitamin C and blood pressure finds mixed results.  I think it all comes down to dosing.  The authors highlight 2 studies to make their point. One find a significant reduction and another found a slight increase.  The dosing of the vitamin C was only 500 mg/day.  A woefully inadequate therapeutic dosing of vitamin C, especially when dealing with the significant deficiencies that can be found in disease states.
Nathan Goodyear

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative... - 0 views

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    animal study finds vitamin C improves hypertension via renovascular source and oxidative stress.  The dosage was 150 mg/kg/day.  This would be equivalent to 10,800 grams daily for a 72 human.  But what about a 200 lb male or female?  That would be 13,650 grams of vitamin C daily.
Nathan Goodyear

Association Between Plasma Vitamin C Concentrations and Blood Pressure in the European ... - 0 views

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    study of almost 21,000 women finds patients with the highest serum vitamin c was associated with the lowest blood pressure.  "We found a strong linear association between plasma vitamin C concentrations and systolic blood pressure.
Nathan Goodyear

Vitamin C in plasma is inversely related to blood pressure and change in blood pressure... - 0 views

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    serum vitamin C levels is found to be inversely associated with blood pressure in healthy you black and white women.
Nathan Goodyear

Plasma ascorbic acid concentrations relate inversely to blood pressure in human subject... - 0 views

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    only abstract available here.  Serum vitamin C levels significantly inversely associated with systolic and diastolic blood pressure.  Also of note, this was a human study, not animal.
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