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Nathan Goodyear

5B.06: ASSOCIATION OF PLASMA TESTOSTERONE WITH CENTRAL HAEMODYNAMICS IN HYPERTENSIVE ME... - 0 views

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    low total Testosterone is associated with increased central blood pressure elevation.  Less association was found with peripheral blood pressure.
Nathan Goodyear

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and o... - 0 views

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    Animal study finds the combination of coconut oil and exercise training reduced oxidative stress and lowered blood pressure.
Nathan Goodyear

ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views

  • Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
  • T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
  • SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
  • ...8 more annotations...
  • SHBG has been postulated as a marker for insulin resistance
  • In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
  • In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
  • E2 may also induce insulin resistance and thereafter tend to raise BP.
  • strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
  • In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
  • estrone levels were positively associated with inflammatory markers in postmenopausal women
  • higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
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    Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Nathan Goodyear

http://www.eurjmedres.com/content/pdf/s40001-014-0056-6.pdf - 0 views

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    Testosterone therapy in obese men with type II Diabetes and low T improved weight,  lipids, HgbA1c, and blood pressure.  There was more improvement with Leptin than with diet/exercise alone.

    What is very important is that the control group (diet, exercise, DM meds) had improvement in Testosterone levels, HgbA1c, lipids, BMI, and blood pressure; just not as strong as the treatment arm with Testosterone.
Nathan Goodyear

Catcholamine and nitric oxide systems as targets of... [Life Sci. 2000] - PubMed - NCBI - 0 views

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    Pb reduced NO, increased epinephrine and norepinephrine, increased vascular resistance and RAA system which resulted in hypertension.
Nathan Goodyear

Lead-induced hypertension: possible role of e... [Am J Hypertens. 1993] - PubMed - NCBI - 0 views

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    Low lead exposure causes vasoconstriction in animal study.
Nathan Goodyear

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks - 0 views

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    Lead is associated with elevated blood pressure in black people, though no association is found in white people.
Nathan Goodyear

Lead Exposure and Cardiovascular Disease-A Systematic Review - 0 views

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    review finds evidence dose exist that Pb is associated with a causal relationship with hypertension.
Nathan Goodyear

Kininergic system and arterial hypertensi... [Immunopharmacology. 1999] - PubMed - NCBI - 0 views

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    Animal model finds that Pb induces hypertension at levels similar to general population exposures.
Nathan Goodyear

Cyclooxygenase inhibition reduces blood p... [Clin Exp Hypertens. 2000] - PubMed - NCBI - 0 views

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    Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.
Nathan Goodyear

PLOS ONE: Low Mercury Concentration Produces Vasoconstriction, Decreases Nitric Oxide B... - 0 views

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    Animal model found that low Hg decreased NO availability.  The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system.  The importance here is that low Hg levels induced this change.
Nathan Goodyear

Low mercury concentrations cause oxidative stress and endothelial dysfunction in conduc... - 0 views

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    Hg induces vascular ROS through depletion of glutathione.  This study found that low dose, chronic Hg exposure induced ROS that resulted in vascular dysfunction i.e. hypertension.
Nathan Goodyear

The role of mercury and cadmi... [Altern Ther Health Med. 2007 Mar-Apr] - PubMed - NCBI - 0 views

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    Heavy metals play a role in the development of CVD.  Hg and Cd in particular play a role in hypertension.
Nathan Goodyear

Mercury accumulation and accelerated progres... [Atherosclerosis. 2000] - PubMed - NCBI - 0 views

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    Accumulating Hg associated with increased CIMT and carotid atherosclerosis.
Nathan Goodyear

Hypertension induced by methyl mercur... [Toxicol Appl Pharmacol. 1987] - PubMed - NCBI - 0 views

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    Hg induces hypertension in rat model.
Nathan Goodyear

http://www.scielo.br/pdf/bjmbr/v44n9/1088.pdf - 0 views

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    Nice review on the mechanism of Hg, Pb and gadolinium on the vascular system.  Oxidative stress is increased.  ACE is increased.  Increased vascular reactivity occurs.  Cardiovascular dysfunction results.
Nathan Goodyear

Effects of Long-Term Testosterone Therapy on Patients with "Diabesity": Results of Obse... - 0 views

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    Six years of Testosterone therapy in men with obesity, low T, and type II Diabetes was found to decrease waist circumference, decrease weight, decrease fasting glucose, decrease in HgbA1c and improved systolic/diastolic blood pressure, lipids, CRP, and liver enzymes.
Nathan Goodyear

Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

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    Abstract only available.  Cortisol-cortisone shuttle play a role in hypertension.  Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
Nathan Goodyear

Association of fructose consumption and components... [Nutrition. 2014] - PubMed - NCBI - 0 views

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    Fructose intake associate with increased fasting blood sugar, elevated triglycerides, and elevated systolic blood pressure--all parameters of metabolic syndrome.
Nathan Goodyear

Hypogonadism and Metabolic Syndrome in Nigerian Male Patients With Both Type 2 Diabetes... - 0 views

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    Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.
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