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Nathan Goodyear

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury... - 0 views

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    Animal study finds that methyl Hg is not useful in determining effects of ethyl mercury.  According to this study, the conclusion is that the ethyl Mercury from Thimerosal is converted to inorganic Hg as evident in the results.  So, in essence, the ethyl mercury, considered less toxic than methyl mercury, is converted to inorganic Mercury a more toxic compound.  The results of the study revealed a higher % of inorganic Hg in the brains of those exposed to thimerosal to those exposed to methylMercury.
Nathan Goodyear

https://dl-web.dropbox.com/get/Public/Research/ane_7212-1.pdf?w=AABZMjLPg8k92S9AxmjD0IN... - 0 views

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    Good non biased look at heavy metals, particularly Hg, and autism.  The authors of this study found the same neurologic pathology biochemically in Hg poisoning as in autism.  
Nathan Goodyear

The plausibility of a role for mercury in the etiology of autism: a cellular perspective - 0 views

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    This is a good review of the biochemistry behind Hg effects on biochemistry. This article tries to review the data objectively to help analyze the Hg-autism link. Too much political polarization of this issue has occurred. Politics has no place in this debate--only a debate of the science!
Nathan Goodyear

Low mercury concentrations cause oxidative stress and endothelial dysfunction in conduc... - 0 views

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    Hg induces vascular ROS through depletion of glutathione.  This study found that low dose, chronic Hg exposure induced ROS that resulted in vascular dysfunction i.e. hypertension.
Nathan Goodyear

PLOS ONE: Low Mercury Concentration Produces Vasoconstriction, Decreases Nitric Oxide B... - 0 views

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    Animal model found that low Hg decreased NO availability.  The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system.  The importance here is that low Hg levels induced this change.
Nathan Goodyear

Association of serum lead and mercury level with cardiometabolic ri... - PubMed - NCBI - 0 views

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    study finds Pb and Hg associated with increased cardiometabolic risk factors.  Elevated liver enzymes found to be positively associated with serum Pb levels.  Metabolic Syndrome was found to be associated with higher Pb and Hg levels.
Nathan Goodyear

The role of mercury and cadmi... [Altern Ther Health Med. 2007 Mar-Apr] - PubMed - NCBI - 0 views

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    Heavy metals play a role in the development of CVD.  Hg and Cd in particular play a role in hypertension.
Nathan Goodyear

High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Mono... - 0 views

  • HG significantly increased the expression of monocyte chemoattractant protein-1 (MCP-1), TNF-α, β2-integrin, interleukin-1β, and others. HG treatment increased transcription of the MCP-1 gene, MCP-1 protein levels, and adhesion of THP-1 cells to endothelial cells. HG-induced MCP-1 mRNA expression and monocyte adhesion were blocked by specific inhibitors of oxidant stress, protein kinase C, ERK1/2, and p38 mitogen-activated protein kinases
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    High glucose associated with significant increase in inflammatory signaling.
Nathan Goodyear

Evidence that mercury from silver dental f... [Sci Total Environ. 1994] - PubMed - NCBI - 0 views

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    this study suggest, that in some, Hg fillings can contribute to MS.  I believe that detoxification compromise also is required.
Nathan Goodyear

Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced... - 0 views

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    Lipopolysaccharide, LPS, released from gram negative bacteria exacerbates the innate immune system response to mercury.  This study found increased IgG1 and IgE levels increased in response to Hg with the presence of LPS.   This study looked at the autoimmune impact of LPS in autism.
Nathan Goodyear

Mercury Levels in Newborns and Infants After Receipt of Thimerosal-Containing Vaccines - 0 views

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    good letter to the editor on the accumulation of inorganic Hg in the brain from Thimerosal.
Nathan Goodyear

Polychlorinated biphenyls, lead, and... [Environ Health Perspect. 2010] - PubMed - NCBI - 0 views

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    PCBs, Pb, and Hg associated with elevated liver enzymes, and non-alcohol fatty liver disease.  
Nathan Goodyear

Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems - 0 views

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    Good review of the toxic effects of Hg on the CNS and cardiovascular system.
Nathan Goodyear

http://www.scielo.br/pdf/bjmbr/v44n9/1088.pdf - 0 views

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    Nice review on the mechanism of Hg, Pb and gadolinium on the vascular system.  Oxidative stress is increased.  ACE is increased.  Increased vascular reactivity occurs.  Cardiovascular dysfunction results.
Nathan Goodyear

Hypertension induced by methyl mercur... [Toxicol Appl Pharmacol. 1987] - PubMed - NCBI - 0 views

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    Hg induces hypertension in rat model.
Nathan Goodyear

Effects of mercury on the isolated he... [Toxicol Appl Pharmacol. 1999] - PubMed - NCBI - 0 views

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    Hg damages the heart muscle.  In this animal study, protection of sulfhidyrl groups prevented this effect.  Examples of sulfhidryl groups is GSH, ALA, cysteine, and NAC.
Nathan Goodyear

Cyclooxygenase inhibition reduces blood p... [Clin Exp Hypertens. 2000] - PubMed - NCBI - 0 views

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    Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.
Nathan Goodyear

Mercury accumulation and accelerated progres... [Atherosclerosis. 2000] - PubMed - NCBI - 0 views

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    Accumulating Hg associated with increased CIMT and carotid atherosclerosis.
Nathan Goodyear

Chronic inorganic mercury induced peripheral neuropathy. - PubMed - NCBI - 0 views

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    Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy.  The exposure in this case study was through herbal supplements.
Nathan Goodyear

Accumulation of methylmercury and inorganic mercury in the brain - Springer - 0 views

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    Mercury does bioaccumulate in the brain.  This is important as Hg is a significant neurotoxin.
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