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Nathan Goodyear

Regulation of Cyclooxygenase-2 Expression in Monocytes by Ligation of the Receptor for ... - 0 views

www.jbc.org/...34834.full

COX2 AGE advanced glycation end products RAGE inflammation

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    good article on the biochemistry of COX2 in inflammation.  Particularily with AGE and it the receptors RAGE.  COX2 has been shown to decrease insulin secretion through inhibition of islet cell production, but in the presence of disease level inflammation, COX2 can be a part of a very dangerous autocrine/paracrine loop.
Nathan Goodyear

Cyclooxygenase inhibition reduces blood p... [Clin Exp Hypertens. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10744360

cyclooxygenase NO Hg mercury heart health COX cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model.  Hg has been shown to both inhibit NO synthase and increase COX.
Nathan Goodyear

Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX... - 0 views

www.ncbi.nlm.nih.gov/...PMC2789773

essential oil essential oils LPS COX2 cox-2 cyclooxygenase inflammation thyme natural

shared by Nathan Goodyear on 29 Sep 14 - No Cached
  • Nathan Goodyear on 29 Sep 14
     
    essential oils inhibit LPS induced COX-2 activity.
Nathan Goodyear

INAUGURAL ARTICLE by a Recently Elected Academy Member:COX-2 mediates tumor-stromal pro... - 0 views

www.ncbi.nlm.nih.gov/...PMC6431196

COX-2 prolactin cancer

shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Cox-2 found to increase prolactin expression to increase metastatic spread of cancer cells. Cox-2 may work here more in the autocrine/paracrine prolactin signaling. This is an animal study.
Nathan Goodyear

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by... - 0 views

www.researchgate.net/...r_by_a_dual_COX-2sEH_inhibitor

chemotherapy COX2 ovarian cancer COX-2 cytokine storm

shared by Nathan Goodyear on 06 Apr 20 - No Cached
  • Nathan Goodyear on 06 Apr 20
     
    COX2 inhibition used to counter chemotherapy induced cytokine storm metastasis.
Nathan Goodyear

Surgically induced accelerated local and distant tumor growth is significantly attenuat... - 0 views

pubmed.ncbi.nlm.nih.gov/15734421

cancer metastasis surgery

shared by Nathan Goodyear on 13 Aug 20 - No Cached
  • Nathan Goodyear on 13 Aug 20
     
    Cox II inhibition helps to slow surgical induced metastatic and local recurrence of cancer. Surgery does cause metastasis and local recurrence and cox II inhibition stops spread.
Nathan Goodyear

The COX-2 inhibitor celecoxib and its use in the management of prostate cancer. | Cance... - 0 views

cancerres.aacrjournals.org/...1239.4

cox-2 cancer prostate cancer Celebrex

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    COX-2 inhibition therapy useful in the treatment of prostate cancer?
Nathan Goodyear

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by... - 0 views

www.pnas.org/...1698

metastasis chemotherapy COX2

shared by Nathan Goodyear on 08 Apr 20 - No Cached
  • Nathan Goodyear on 08 Apr 20
     
    COX2 inhibition to slow/block chemotherapy induced metastasis.
Nathan Goodyear

Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by d... - 0 views

www.ncbi.nlm.nih.gov/...PMC4406257

gastric cancer COX2 artesunate

shared by Nathan Goodyear on 07 May 20 - No Cached
  • Nathan Goodyear on 07 May 20
     
    Artesunate inhibits gastric cancer cells via COX2 inhibition.
Nathan Goodyear

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-tr... - 0 views

www.ncbi.nlm.nih.gov/...18522674

low Testosterone Testosterone male hormones inflammation LPS lipopolysaccharides

shared by Nathan Goodyear on 13 Apr 17 - No Cached
  • Nathan Goodyear on 13 Apr 17
     
    Animal study from '09 found that COX2 inhibitor blunted LPS decrease in testes weight, decrease in testicular interstitial fluid, and serum Testosterone.  The point here is that LPS, in this animal model, decreased gonadal weight and Testosterone production and the anti inflammatory, COX2, blunted that effect.
Nathan Goodyear

Selective Association of Peroxiredoxin 1 with Genomic DNA and COX-2 Upstream Promoter E... - 0 views

www.ncbi.nlm.nih.gov/...PMC2929992

COX-2 metastasis chemotherapy cancer

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    the chemotherapy, cisplatin, found to increase COX-2 expression in breast cancer cell lines that is required for metastasis.
Nathan Goodyear

Effects of garlic on platelet biochemistry and physiology - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/17966136

allicin COX2 cyclooxygenase garlic platelets COX-2

shared by Nathan Goodyear on 08 Jun 23 - No Cached
  • Nathan Goodyear on 08 Jun 23
     
    Allicin inhibits platelet aggregation via COX2 inhibition.
Nathan Goodyear

Progesterone receptor plays a major antiinfla... [Mol Endocrinol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16772530

progesterone receptor progesterone receptors PR inflammation NF-KappaB progesterone receptor receptors COX-2

shared by Nathan Goodyear on 26 Nov 12 - No Cached
  • Nathan Goodyear on 26 Nov 12
     
    progesterone receptor inhibits inflammation through NF-kappaB inhibition and through lack of activation of COX-2.
Nathan Goodyear

ScienceDirect.com - Free Radical Biology and Medicine - Anti-inflammatory effects of be... - 1 views

www.sciencedirect.com/...S0891584911011087

benfotiamine inflammation arachidonic acid LOX-5 COX-2

shared by Nathan Goodyear on 13 Jul 12 - No Cached
  • Nathan Goodyear on 13 Jul 12
     
    Benfotiamine's anti-inflammatory effect is through the inhibition of LOX-5 and COX-2.
Nathan Goodyear

JAMA Network | Archives of Neurology | Neuronal Cyclooxygenase 2 Expression in the Hipp... - 0 views

archneur.jamanetwork.com/article.aspx

COX-2 inflammation dementia AD Alzheimer's disease neurology brain

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    COX-2 expression associated with increasing dementia in AD.
Nathan Goodyear

Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments b... - 0 views

www.ncbi.nlm.nih.gov/...PMC3825202

RG3 inflammation brain memory learning ginsenoside panax ginseng panax ginseng TNF-alpha IL-1beta cox-2 cognition

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    Rat model induced inflammatory reaction in brain via LPS injection.  The result was impaired memory.  RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
Nathan Goodyear

Cyclooxygenase-2 Induces EP1- and HER-2/Neu-Dependent Vascular Endothelial Growth Facto... - 0 views

cancerres.aacrjournals.org/...554

COX-2 cancer HER-2 Celebrex VEGF metastasis prostate cancer lung cancer colorectal cancer

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    COX-2 is overexpressed in a variety of human cancers i.e. colorectal, prostate, lung adenocarcinoma.  This study hightlights the increased tumor metastatic potential via upregulation of VEGF-C via EP1 and HER-2 dependent pathways.  This upregulation was correlated with survival and mets.
Nathan Goodyear

3-Phosphoinositide-Dependent Protein Kinase-1/Akt Signaling Represents a Major Cyclooxy... - 0 views

cancerres.aacrjournals.org/...1444

cox-2 Celebrex cancer prostate cancer

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    COX-2 therapy can inhibit tumor growth and even promote apoptosis in prostate cell model.
Nathan Goodyear

Intraperitoneal Oxidative Stress in Rabbits with Papillomavirus-Associated Head and Nec... - 0 views

clincancerres.aacrjournals.org/...4289.long

Ozone cancer COX-2 immunotherapy NK cells NK

shared by Nathan Goodyear on 02 Nov 18 - No Cached
  • Nathan Goodyear on 02 Nov 18
     
    O2-O3 triggers tumoricidal immune response after application of a repetitive highly oxidative stimulus by insufflation of a medical O3/O2 gas mixture into the peritoneal cavity in animal model. O3/O2-PP treatment, indicates an enhanced activation of the innate and adaptive arms of the immune system, implicating a role of activated TILs In the anti cancer effects of the O3. Interestingly, COX2 expression was decreased.
Nathan Goodyear

Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expressi... - 0 views

www.ncbi.nlm.nih.gov/...PMC2778514

cyclooxygenase aromatase inhibition cancer COX2 aromatase melatonin aromatase inhibitor

shared by Nathan Goodyear on 17 Nov 21 - No Cached
  • Nathan Goodyear on 17 Nov 21
     
    Melatonin downregulates aromatase expression through COX2
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