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Nathan Goodyear

Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acry... - 0 views

www.researchgate.net/...-induced_neurotoxicity_in_rats

RG3 panax ginseng neurotoxin brain acrylamide hormones

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    RG3, an extract from panax ginseng, found to protect against the neurotoxin acrylamide.   Also of interest, is that serotonin, corticosterone, T3, T4, estradiol, progesterone and epinephrine were all decreased in this acrylamide rat model.
Nathan Goodyear

VITAMINS AND ENTACAPONE IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA: A RANDOMIZED CONTROLL... - 0 views

www.neurology.org/...1440.extract

Levodopa parkinson's disease Parkinson's homocysteine neurodegenerative disease vitamins

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    It appears that Levodopa administration in those with Parkinson's disease will deplete methylation (SAMe), and thus increase homocysteine, which is a neurotoxin.  Additionally, depletion of methylation is associated with depression, commonly seen in Parkinson's disease
Nathan Goodyear

http://www.2ndchance.info/onesize4all-Perricone2013.pdf - 0 views

www.2ndchance.info/onesize4all-Perricone2013.pdf

aluminum Macrophagic myofasciitis ASIA autoimmune disease autoimmune disease Autoimmune_inflammatory syndrome induced by adjuvants vaccines vaccinations

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Absolute must read!  Science. That is what physicians are.  Eliminate politics and bias.  Aluminum, common adjuvant in vaccines and well known neurotoxin, has been linked to post vaccine macrophagic myofascitis.  Now, world experts have placed it at the forefront of a new created syndrome "ASIA" which is autoimmune/inflammatory syndrome induced by adjuvants.  
Nathan Goodyear

Accumulation of methylmercury and inorganic mercury in the brain - Springer - 0 views

link.springer.com/...10.1007%2FBF02917253

mercury brain

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Mercury does bioaccumulate in the brain.  This is important as Hg is a significant neurotoxin.
Nathan Goodyear

Ascorbate inhibits edema in brain slices. | Mendeley - 0 views

www.mendeley.com/...te-inhibits-edema-brain-slices

vitamin C excitotoxicity neurotoxin brain edema glutamate glutamic acid

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    vitamin C shown to reduce brain edema associated with glutamate excitotoxicity
Nathan Goodyear

Occupational mercury exposure and its consequences... [Int Arch Occup Environ Health. 1... - 0 views

www.ncbi.nlm.nih.gov/...7129652

mercury exposure occupational cognitive function memory behaviour

shared by Nathan Goodyear on 22 Feb 11 - No Cached
  • Mercury is a known neurotoxin
  • Nathan Goodyear on 22 Feb 11
     
    inorganic effects of mercury on behaviour and cognitive function
Nathan Goodyear

Frontiers | Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of... - 0 views

journal.frontiersin.org/...full

LPS lipopolysaccharides Alzheimer's disease brain inflammation

shared by Nathan Goodyear on 23 Sep 17 - No Cached
  • lipopolysaccharides (LPS), either alone or in combination, have indicated that when compared, bacterial LPSs exhibit the strongest induction of pro-inflammatory signaling in human neuronal–glial cells in primary coculture of any single inducer, and different LPS extracts from different gastrointestinal (GI)-tract resident Gram-negative bacteria appeared to have different pro-inflammatory potential
  • powerful inducer of the NF-κB
  • In both neocortex and hippocampus, LPS has been detected to range from a ~7- to ~21-fold increase abundance in AD brain
  • ...15 more annotations...
  • Major Gram-negative bacilli of the human GI-tract, such as the abundant B. fragilis and Escherichia coli (E. coli), are capable of discharging a remarkably complex assortment of pro-inflammatory neurotoxins
  • (i) bacterial amyloids (10, 21); (ii) endotoxins and exotoxins (5, 12); (iii) LPS (12, 18); and (iv) small non-coding RNAs (sncRNAs)
  • integral components of the outer leaflet of the outer membrane of Gram-negative bacteria, LPS
  • LPS, the major molecular component of the outer membrane of Gram-negative bacteria normally serves as a physical barrier providing the bacteria protection from its surroundings
  • LPS is also recognized by the immune system as a marker for the detection of bacterial pathogen invasion and responsible for the development of inflammatory response is perhaps the most potent stimulator and trigger of inflammation known
  • AD-affected brains have remarkably large loads of bacterial-derived toxins compared to controls. The transfer of noxious, pro-inflammatory molecules from the GI-tract microbiome to the CNS may be increasingly important during the course of aging when both the GI-tract and blood–brain barriers become significantly more permeable
  • first evidence of a perinuclear association of LPS with AD brain cell nuclei
  • LPS-mediated stimulation of chronic inflammation, beta-amyloid accumulation, and episodic memory decline in murine models of AD (39, 40) and a biophysical association of LPS with amyloid deposits and blood vessels in human AD patients
  • Strong adherence of LPS to the nuclear periphery has recently been shown to inhibit nuclear maturation and function that may impair or block export of mRNA signals from brain cell nuclei, a highly active organelle with extremely high rates of transcription, mRNA processing, and export into the cytoplasm
  • LPS may be further injurious to the nuclear membrane just as LPS contributes to cerebrovascular endothelial cell membrane injury
  • high intake of dietary fiber is a strong inhibitor of B. fragilis abundance and proliferation in the intact human GI-tract and as such is a potent inhibitor of the neurotoxic B. fragilis-derived amyloids, LPS, enterotoxins, and sncRNAs.
  • GI-tract microbiome-derived LPS may be an important initiator and/or significant contributor to inflammatory degeneration in the AD CNS
  • LPS has been recently localized to the same anatomical regions involved in AD-type neuropathology
  • a known pro-inflammatory transcription factor complex that triggers the expression of pathogenic pathways involved in neurodegenerative inflammation
  • pro-inflammatory amyloids, endo- and exotoxins, LPSs, and sncRNAs but also serve as potent sources of membrane-disrupting agents
  • Nathan Goodyear on 23 Sep 17
     
    LPS links gut to inflammation in Alzheimer's disease
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