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Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929731

BPA bisphenol A cancer prostate cancer prostate xenoestrogens

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
  • ...13 more annotations...
  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
  • Nathan Goodyear on 20 Apr 16
     
    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23941471

BPA Bisphenol A Bisphenol-A endocrine disruptor EDC

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

CDC - NER - Fact Sheets - BPA - 0 views

www.cdc.gov/...BisphenolA_FactSheet.html

BPA bisphenol A environmental toxins

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    All people in study shown to have elevated BPA.  The statement "human health effects from BPA at low environmental exposures are unknown" is ridiculous.  Recent 2011 study from NIH showed how the pharmacokinectics of BPA in women is very similar to that of monkeys and mice.
Nathan Goodyear

Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-R... - 0 views

www.ncbi.nlm.nih.gov/...PMC3566099

bisphenol A Bisphenol-A BPA toxin prostate disease

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    animal model, but Bisphenol A shown to increase aromatase production.  This aids the decreased T:E2 ratio that is commonly found in prostate disease.  So, BPA is a xenoestrogen.  BPA is an androgen receptor antagonist and BPA increases aromatase activity.  
Nathan Goodyear

Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

endo.endojournals.org/...s56.full

BPA bisphenol A pregnant children hormone receptors environment environmental toxins

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    Very low levels of BPA shown to be present in pregnant and unborn children.  These levels exceed the levels at which documented receptor change occurs as the result of BPA.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
Nathan Goodyear

Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormon... - 0 views

pubs.acs.org/...es9028292

BPA Bisphenol-A bisphenol infertility men's health men E2:T free androgen index hypothyroidism TSH low T testosterone

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Proge... [Endocrinology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24424067

BPA bisphenol A Bisphenol-A prostate cancer xenoestrogen xenoestrogens

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Another strike against BPA.  This time, BPA exposure during development increased hormone-dependent cancer risk in the prostate through its interaction with prostate stem-progenitor cells.  Again, we are being altered prior to birth.
Nathan Goodyear

EHP - Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular... - 0 views

ehp.niehs.nih.gov/1205823

Bisphenol A estrogen E2 Estradiol xenoestrogens xenoestrogen hormone hormones BPA

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults.  The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure.  BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.
Nathan Goodyear

Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Hu... - 0 views

www.ncbi.nlm.nih.gov/...PMC3080921

BPA Bisphenol A environmental Toxin

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    BPA levels in people is much higher than previously suspected.   Additionally, how the BPA works in women is similar to that in monkeys and mice.  Remember, most of the studies have been done on mice and monkeys.
Nathan Goodyear

Bisphenol A (BPA) Information for Parents - 0 views

www.hhs.gov/bpa

BPA bisphenol A children

shared by Nathan Goodyear on 10 Oct 11 - Cached
  • Nathan Goodyear on 10 Oct 11
     
    great review of BPA for parents.
Nathan Goodyear

Parent bisphenol A accumulation in the human mater... [Environ Health Perspect. 2002] -... - 0 views

www.ncbi.nlm.nih.gov/...12417499

BPA endocrine disurptor

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • Exposure levels of parent BPA were found within a range typical of those used in recent animal studies and were shown to be toxic to reproductive organs of male and female offspring
  • BPA blood concentrations were higher in male than in female fetuses
  • Nathan Goodyear on 01 Jul 11
     
    Mother's exposure to toxic BPA passed to her child
Nathan Goodyear

Thyroid hormone action is disrupted by bisphenol A... [J Clin Endocrinol Metab. 2002] -... - 0 views

www.ncbi.nlm.nih.gov/...12414890

BPA Bisphenol A thyroid function T3

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • These results suggest that BPA could displace T(3) from the TR
  • This is the first report that BPA can antagonize T(3) action at the transcriptional level
  • Nathan Goodyear on 01 Jul 11
     
    BPA disrupts thryroid function
Nathan Goodyear

Sex-specific effects of long-term exposure to bi... [Chemosphere. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25112706

bisphenol A BPA xenoestrogens ER beta ER-beta hormone hormones anxiety depression

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice. Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.
Nathan Goodyear

An extensive new literature concerning low-dose ef... [Environ Health Perspect. 2005] -... - 0 views

www.ncbi.nlm.nih.gov/...16079060

BPA toxic Bisphenol A

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • reports that the median BPA level in human blood and tissues, including in human fetal blood, is higher than the level that causes adverse effects in mice
  • Nathan Goodyear on 01 Jul 11
     
    low dose exposures of BPA toxic
Nathan Goodyear

Determination of bisphenol A concentrations in hum... [Hum Reprod. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12407035

BPA pregnancy baby

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • he potential for human exposure to endocrine-disrupting chemicals
  • suggest accumulation of BPA in early fetuses and significant exposure during the prenatal period
  • Nathan Goodyear on 01 Jul 11
     
    BPA is found in significant levels in the prenatal period
Nathan Goodyear

Serum bisphenol-A concentration and sex hormone levels in men - 0 views

www.fertstert.org/...abstract

BPA hormone hormones xenoestrogen Bisphenol-A low testosterone low T testosterone male man SHBG

shared by Nathan Goodyear on 09 May 13 - No Cached
  • Nathan Goodyear on 09 May 13
     
    Study finds that men exposed to BPA have lower androstenedione and free testosterone compared to those not exposed.  Also of note, SHBG is increased, which is what one would expect with xenoestrogen exposure.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

press.endocrine.org/...en.2015-1937

BPA toxins environmental toxins xenoextrogens bisphenol A hormones

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

http://ehp.niehs.nih.gov/wp-content/uploads/advpub/2016/5/EHP205.acco.pdf - 0 views

ehp.niehs.nih.gov/...EHP205.acco.pdf

obesity bisphenol A BPA EDC toxins environmental toxins endocrine disrupting chemicals

shared by Nathan Goodyear on 08 Jun 16 - No Cached
  • Nathan Goodyear on 08 Jun 16
     
    mothers with BPA exposure and thus prenatal exposure, increases risk of obesity risk in child.
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