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Nathan Goodyear

Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expres... - 0 views

www.ncbi.nlm.nih.gov/...PMC1892114

xenoestrogens bisphenol A estrogen hormone hormones androgen receptor receptors estrogen receptor prostate

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    Great read on the effects of bisphenol A as an xenoestrogen.  Bisphenol A is a weak estrogen, but it does increase androgen receptor and estrogen receptor alpha transcription.  This is from fetal exposure.
Nathan Goodyear

Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA an... - 0 views

www.ncbi.nlm.nih.gov/...PMC2717129

Bisphenol-A xenoestrogens xenoestrogen hormone hormones

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A: review of the different biochemical effects of bisphenol A.
Nathan Goodyear

Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Recept... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649216

ER-alpha estrogen receptor Bisphenol A toxins cancer breast

shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.
Nathan Goodyear

Association between urinary levels of bisp... [Sci Total Environ. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23954212

bisphenol A Bisphenol-A BPA estrogen metabolism hormone hormones xenoestrogens xenoestrogen

shared by Nathan Goodyear on 19 Jun 14 - No Cached
  • Nathan Goodyear on 19 Jun 14
     
    Bisphenol A (BPA) negatively effects estrogen metabolism. Bisphenol A preferentially increases 4OH-estrone which is the most toxic estrogen metabolite.
Nathan Goodyear

Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-R... - 0 views

www.ncbi.nlm.nih.gov/...PMC3566099

bisphenol A Bisphenol-A BPA toxin prostate disease

shared by Nathan Goodyear on 12 Dec 13 - No Cached
  • Nathan Goodyear on 12 Dec 13
     
    animal model, but Bisphenol A shown to increase aromatase production.  This aids the decreased T:E2 ratio that is commonly found in prostate disease.  So, BPA is a xenoestrogen.  BPA is an androgen receptor antagonist and BPA increases aromatase activity.  
Nathan Goodyear

Structural and mechanistic insights into bisphenols action provide guidelines for risk ... - 0 views

www.pnas.org/...1203574109.abstract

BPA bisphenol A ER estrogen receptor agonist hormone hormones

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    bisphenol A is a estrogen receptor agonist, though partial.
Nathan Goodyear

Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormon... - 0 views

pubs.acs.org/...es9028292

BPA Bisphenol-A bisphenol infertility men's health men E2:T free androgen index hypothyroidism TSH low T testosterone

shared by Nathan Goodyear on 12 Dec 11 - No Cached
  • Nathan Goodyear on 12 Dec 11
     
    Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
Nathan Goodyear

Bisphenol A and human health: A review of the... [Reprod Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23994667

bisphenol A Bisphenol-A BPA endocrine disruptor xenoextrogen

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Bisphenol A proving to be an significant endocrine disruptor in humans.
Nathan Goodyear

Bisphenol A may cause testosterone reduction by adversely affecting both testis and pit... - 0 views

www.sciencedirect.com/...S0378427410000561

testosterone Bisphenol-A Bisphenol A BPA low T leydig cells pituitary

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Bisphenol-A inhibits testosterone production through direct inhibition of the pituitary and the leydig cells.  This is similar to the way E2 acts on the the pituitary and the leydig cells.  
Nathan Goodyear

Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of fem... - 0 views

joe.endocrinology-journals.org/...201.abstract

bisphenol A Bisphenol-A BPA kisspeptin LH FSH Estradiol estrogen hormones female

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Mouse model finds that Bisphenol A (BPA) induces LH/FSH and Estradiol production through kisspeptin stimulation.
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929731

BPA bisphenol A cancer prostate cancer prostate xenoestrogens

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
  • ...13 more annotations...
  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
  • Nathan Goodyear on 20 Apr 16
     
    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
Nathan Goodyear

Diverse Influences of Androgen-Disrupting Chemi... [Inflammation. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287822

Bisphenol-A bisphenol A BPA EDC endocrine disrupting chemicals NO inflammation

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Study proposed immune dysfunction as a result of EDC like BPA. Bisphenol A induced cell apoptosis as well as a reduction of nitric oxide.
Nathan Goodyear

Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expres... - 0 views

www.ncbi.nlm.nih.gov/...PMC1892114

environmental toxins environment bisphenol A inflammation cancer estrogen receptors androgen receptors ER AR estrogen receptors androgen hormone hormones

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    environmental toxin, bisphenol A, shown to increase estrogen receptor and androgen receptor expression in the prostate.  Also, a shift from ER beta to ER alpha occurs, increase the inflammatory and proliferative signal.
Nathan Goodyear

Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor ... - 0 views

joe.endocrinology-journals.org/...201.full

Bisphenol A ER estrogen receptor alpha hormone hormones toxins

shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    In a rat study, Bisphenol A shown to increase the ER alpha expression in the hypothalamus of the offspring.  So, the effects occur in utero, prior to birth.  The impact is this: the signal interpretation, by the tissue, of the hormone signal is altered prior to birth?
Nathan Goodyear

Low dose of bisphenol A impairs the reprod... [J Physiol Biochem. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24271643

BPA bisphenol A

shared by Nathan Goodyear on 29 Nov 13 - No Cached
  • Nathan Goodyear on 29 Nov 13
     
    BPA shown to effect HPA in rats.  The effects were seen as a result of pre and post natal exposure of low dose bisphenol A.  Testosterone was not found to be negatively impacted.  
Nathan Goodyear

EHP - Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular... - 0 views

ehp.niehs.nih.gov/1205823

Bisphenol A estrogen E2 Estradiol xenoestrogens xenoestrogen hormone hormones BPA

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults.  The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure.  BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.
Nathan Goodyear

Bisphenol-A acts as a potent estrogen vi... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22227557

Bisphenol-A xenoestrogen xenoestrogens hormone hormones

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A acts via non-classical genomic signaling and more through weaker non-classical membrane receptors and their secondary messengers.
Nathan Goodyear

Bisphenol A Effects on Estrogen Receptor β Expression: Implications in Prosta... - 0 views

www.niehs.nih.gov/...index.cfm

BPA bisphenol A ER-beta prostate estrogen receptors ER estrogen receptors cancer

shared by Nathan Goodyear on 21 Nov 12 - No Cached
  • Nathan Goodyear on 21 Nov 12
     
    Bisphenol A downgregulates ER-beta in male prostate.  This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications  in prostate health.
Nathan Goodyear

Exposure to the environmental estrogen bisphenol A ... [Life Sci. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12505546

Bisphenol-A ER alpha ER beta estrogen receptor estrogen receptor alpha estrogen receptor beta hormone hormones

shared by Nathan Goodyear on 14 May 13 - No Cached
  • Nathan Goodyear on 14 May 13
     
    Bisphenol A causes shift in ER-beta to ER-alpha through increase ER alpha transcription in the testis.  This only looked at ER expression in the testis.
Nathan Goodyear

The activity of bisphenol A depends on both the est... [Endocr J. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12402979

bisphenol A ER estrogen receptor receptors hormone hormones agonist antagonist estrogen receptor BPA

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    bisphenol A is shown to be both an ER agonist and an ER antagonist.
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