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Insulin is a hormone produced by the pancreas to control blood sugar. Diabetes can be caused by too little insulin, resistance to insulin, or both. To understand diabetes, it is important to first understand the normal process by which food is broken down and used by the body for energy. Several things happen when food is digested: A sugar called glucose enters the bloodstream. Glucose is a source of fuel for the body. An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel. People with diabetes have high blood sugar because their body cannot move sugar into fat, liver, and muscle cells to be stored for energy. This is because either: Their pancreas does not make enough insulin Their cells do not respond to insulin normally Both of the above There are two major types of diabetes. The causes and risk factors are different for each type: Type 1 diabetes can occur at any age, but it is most often diagnosed in children, teens, or young adults. In this disease, the body makes little or no insulin. Daily injections of insulin are needed. The exact cause is unknown. Type 2 diabetes makes up most diabetes cases. It most often occurs in adulthood. However, because of high obesity rates, teens and young adults are now being diagnosed with it. Many people with type 2 diabetes do not know they have it. Gestational diabetes is high blood sugar that develops at any time during pregnancy in a woman who does not have diabetes. Diabetes affects more than 20 million Americans. Over 40 million Americans have pre-diabetes (which often comes before type 2 diabetes).

Study of memantine finds effect on insulin is the same in the brain as in the pancreas.  In essence, Alzheimer's disease, is in part, a diabetes of the brain disease.

Abstract of an animal model look at the use of Pancreatic enzyme therapy in the treatment of pancreatic cancer.  

In vitro studies confirm reduced viability of melanoma, rhabdomyoscarcoma, gastric adenocarcinoma, lun carcinoma, and pancreas adenocarcinoma cells with the use of the oncolytic RIGVIR virus

inflammation leads to death of pancreatic beta cells and result in diabetes.

inflammatory cytokines lead to progressive pancreatic Beta islet cells dysfunction and resultant diabetes.

Great pictorials of the biochemistry of metabolic syndrome.

Zn show to help in glycemic control in both type I and II diabetics.  It appears to do this through inflammation reduction and thus improved insulin/Receptor signal transduction.   Also of note, antibodies against Zn transporter have been found in type I DM.

Nice review of the data, up to the publication date, on creatine.

pancreatic cancer survival risk is shorted by 2.43 with elevated estradiol in women.  This risk is linked to an increase in TNF alpha.  In contrast, men survival risk was worse by 1.96 odds ratio with low Testosterone.  Again, inflammation was the culprit.

macronutrient intake and effect on glucose regulation and thus metabolism.

Metformin useful in the prevention of cancer, but also on the treatment as an adjunct.  Good review through possible mechanisms, mToR, insulin, IGF-1...

To be read