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Nathan Goodyear

Utility, Limitations, and Pitfalls in Measuring Testosterone: An Endocrine Society Posi... - 0 views

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    This was a position statement from the Council of the Endocrine Society.  They looked at the reliability of free and total testosterone in serum and their conclusion: "...most assays for TT and FT are currently performed is decidedly unsatisfactory."  Enough said.  Interesting that they didn't look at salivary testosterone testing which has been shown to be extremely reliable and easy to perform.   I wonder how many physicians, insurance companies, state boards of medicine have read this statement?
Nathan Goodyear

Microglial Activation And Neurodegeneration - 0 views

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    short and brief discussion of how microglial inflammation cause neurodegeneration via excitotoxicity.  Dr. Blaylock is the author of this short article.  
Pot Valet

THC and CBD - What's the Difference? | Pot Valet News - 0 views

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    If you're new to the world of marijuana, you might wonder what THC and CBD are and how are they different. It's important to understand the effects of these two substances before you choose what type of marijuana you want.
Nathan Goodyear

Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity - 0 views

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    New study how the Western diet acts like a drug in the body.
Nathan Goodyear

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome... - 0 views

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    New study proposes how altered gut microbiota leads to obesity.  The short answer is increased insulin production, increased gherlin, and older studies suggest inflammation also.
Nathan Goodyear

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels: T... - 0 views

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    new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!
Nathan Goodyear

Circadian Rhythm Disruption Promotes Lung Tumorigenesis: Cell Metabolism - 0 views

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    A proposed mechanism of how night shift work is a carcinogen.
Paul Michael

Every Little Cell Song 3 - YouTube - 0 views

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    EVERY LITTLE CELL song YouTube video "Every Little Cell" song with detail about HOW to use the song for optimal health, healthy living, wellness, wellbeing, positive attitude, healing and healthcare.
hadiyasafdar

How Does fillers and Facelift Surgery Work? - Cosmetic Surgeon - Medium - 0 views

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    Who wouldn't love to look young and beautiful? Minor signs of ageing can make us panic because such signs start appearing one after the other making you look older and less pretty as would look without them. Wrinkles and lines appear because your skin loses its elasticity and volume over time. We know that ageing is an inevitable process but we wish to delay it and look youthful for more and more time.
jasminegibbons

How to Age Gracefully with Proper Posture - 0 views

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    Aging is inevitable but you can always slow it down. As I said, start with posture.
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    Aging is inevitable but you can always slow it down. As I said, start with posture.
Nathan Goodyear

Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival - 0 views

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    Flat and/or abnormal diurnal cortisol patterns found to be associated with earlier mortality in breast cancer.  The flatter cortisol pattern, the earlier the mortality.  Several points here: this highlights the impact of cortisol on the immune system.  Second, this reveals how much of the research has moved to saliva as the gold standard.  This study by the NCI, used salivary cortisol to evaluate the risk of breast cancer survivors.
Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
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    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Why physicians should treat menopause as they treat other permanent hormone deficiencie... - 0 views

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    Good broad-based review of hormones by Dr. Schwarzbein.
Nathan Goodyear

JCI - Chronic inflammation in fat plays a crucial role in the development of obesity-re... - 0 views

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    how inflammation contributes to obesity.  Nice discussion of the inflammatory signaling that leads to obesity.  This occurs predominately in white adipose tissue WAT.  This leads to insulin resistance and type II DM.
Nathan Goodyear

Annals of Internal Medicine | Gene-Diet Interactions in Brain Aging and Neurodegenerati... - 0 views

  • it appears that dietary restriction promotes neuronal survival, plasticity, and even neurogenesis by inducing a mild cellular stress response that involves activation of genes that encode proteins designed to promote neuronal growth and surviva
  • Studies of animal models of Alzheimer disease and Parkinson disease have shown that, by decreasing homocysteine levels, dietary folic acid can be neuroprotective
  • The current average daily calorie intake of Americans is approximately 2700 for women and more than 3000 for men
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    what you eat and how many calories you eat effects you brain and your risk of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.
Nathan Goodyear

Ketoacids? Good medicine? - 0 views

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    Great, great read on how biochemistry effects brain function. Beta-hydroxybutyrate is an alternative fuel source for the brain in times of calorie restriction. This promotes neuroplasticity and neurogenesis without the inflammatory effects of glucose and insulin.
Nathan Goodyear

S-Adenosylmethioninein alcoholic liver cirrhosis: a randomized,placebo-contr... - 0 views

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    full pdf article of previously posted article on SAMe and how it increases CBS activity to increase GSH and thus reduce liver oxidative stress and fat accumulation. SAMe also decreases IL-10 and TNF-alpha.
Nathan Goodyear

Digestive Diseases and Sciences, Volume 57, Number 5 - SpringerLink - 0 views

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    study shows that IBS related to dysbiosis, imbalanced microbial population, in the small intestine.  But, as they always do, their thought of treatment is via the old paradigm.  How, about just restoring the bacterial balance with probiotics, which, themselves will kill the unwelcomed bacteria.
Nathan Goodyear

Rebuilding the post-infarcted myocardium by a... [Heart Fail Rev. 2010] - PubMed - NCBI - 0 views

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    Wow, thyroid hormones play a significant role in cardiac remodeling post MI.  Thyroid hormones, "promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival..."  How many people post-MI are having their thyroid evaluated, let alone correctly evaluated?
Nathan Goodyear

Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol - 0 views

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    Fructose is a major player in the obesity epidemic. This article lays out how fructose disrupts physiology
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