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Nathan Goodyear

JCI - Chronic inflammation in fat plays a crucial role in the development of obesity-re... - 0 views

www.jci.org/19451

inflammation obesity overweight WAT adipose tissue fat insulin resistance type II diabetes DM

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    how inflammation contributes to obesity.  Nice discussion of the inflammatory signaling that leads to obesity.  This occurs predominately in white adipose tissue WAT.  This leads to insulin resistance and type II DM.
francois appers

Extra energie tegen vermoeidheid - 0 views

www.leefnugezonder.be/tra-energie-tegen-vermoeidheid

lente voorjaar moe vermoeid voorjaarsmoeheid oorzaken energietekort extra energie vitaminen mineralen voedingssupplementen

shared by francois appers on 28 Mar 12 - No Cached
  • francois appers on 28 Mar 12
     
    Lang niet iedereen reageert niet even enthousiast over de komst van de lente. Ruim 500000 landgenoten kampen in het vroege voorjaar met lentemoeheid en ernstig energietekort. Wat zijn de oorzaken van voorjaarsmoeheid en tekort aan energie en hoe kun je er aan verhelpen? Kunnen extra vitaminen of voedingssupplementen je helpen ontwaken uit je winterslaap om met volle teugen te genieten van het deugddoende buitenleven?
francois appers

Vakantie in zicht: waa op letten bij huur to? - 0 views

www.leerwiki.nl/_waar_op_letten_bi_uur_auto%3F

vakantie auto huren hoe voordelig verzekering autohuur

shared by francois appers on 10 May 11 - No Cached
  • francois appers on 10 May 11
     
    Met de zomervakantie in zicht, ligt bij de meerderheid van onze landgenoten hun vakantiebestemming ongetwijfeld al geruime tijd vast. Maar hoe is het gesteld met het huren van een auto op onze toekomstige vakantiebestemming? Welk prijskaartje hangt er aan vast, en op wat moeten we zeker letten willen we tijdens onze vakantie voor geen onoverkomenlijke hindernissen worden geplaatst?
francois appers

Soep en extra hyghiëne helpen tegen verkoudheden - 0 views

leefgezonder.blogspot.com/...tra-hyghiene-helpen-tegen.html

giep verkoudheid behandeling kippensoep tegen soep extra hygiëne

shared by francois appers on 24 Aug 11 - No Cached
  • francois appers on 24 Aug 11
     
    Met de start van het nieuwe schooljaar begint meteen ook een nieuw nies en snotterseizoen. Inderdaad, het duurt niet langer dan twee weken of onze hartediefjes komen met hun eerste, maar lang niet de laatste verkoudheid naar huis. Eens de virussen en bacteriën binnenskamers, nestelen ze er zich meestal voor een ganse winter. Het aantal hoesters, niezers en snottebellen zal de komende weken en maanden angstaanjagend stijgen, om tijdens de eindejaarsfeesten naar een hoogtepunt te klimmen. Is er dan niets tegen verkoudheden opgewassen? Wat kunnen we zélf ondernemen om van deze vervelende verkoudheden gespaard te blijven? Kunnen we ons wel wapenen tegen verkoudheden?
Nathan Goodyear

Gut microbiota after gastric bypass in human obesity: increased richness and associatio... - 0 views

ajcn.nutrition.org/...16.abstract

gastric bypass obesity gut microbiota microbiota inflammation WAT white adipose tissue dysbiosis gut

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    Not that I am proposing gastric bypass for weight loss.  IN my mind that is like a lobotomy for headache.  But, this study shows the link between gut bacteria and obesity.  This study documented an increase in the expression of certain bacteria types in the gut.   This was associated with increase in white adipose tissue gene expression.  Linking directly the gut and fat.
Nathan Goodyear

A PGC1-[agr]-dependent myokine that drives brown-fat-like development of white fat and ... - 0 views

www.nature.com/...nature10777.html

Irisin hormone weight-loss PGC1-alpha white fat WAT brown thermogenesis

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Irisin, new recognized hormone, found to stimulate PGC1-alpha conversion of white fat to brown fat.  This increases thermogenesis and fat burning.
Nathan Goodyear

Chronic inflammation in fat plays a crucial role in the development of obesity-related ... - 0 views

www.ncbi.nlm.nih.gov/...PMC296998

obesity inflammation overweight weight-loss WAT white adipose tissue macrophages insulin resistance fat

shared by Nathan Goodyear on 16 Jan 12 - No Cached
  • Nathan Goodyear on 16 Jan 12
     
    chronic low-grade inflammation plays role in development of insulin resistance and eventually obesity.  This occurs in White Adipose Tissue
Nathan Goodyear

Obesity is associated with macrophage accumulation in adipose tissue - 0 views

www.ncbi.nlm.nih.gov/...PMC296995

obesity inflammation overweight weight-loss WAT white adipose tissue M1 macrophages

shared by Nathan Goodyear on 16 Jan 12 - No Cached
  • Nathan Goodyear on 16 Jan 12
     
    obesity is associated with dysfunctional immune response to adipose tissue.  The cause is inflammation from White adipose tissue resultant in increased recruitment of macrophages and resultant further inflammation.  M1 macrophages are the predominate culprit.
Nathan Goodyear

PPARs, Obesity, and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC1783744

obesity inflammation PPARs perioxisome proliferator-activated receptor

shared by Nathan Goodyear on 16 Jan 12 - No Cached
  • increase of 61% within 10 years
  • Many of the inflammatory markers found in plasma of obese individuals appear to originate from adipose tissue
  • obesity is a state of chronic low-grade inflammation that is initiated by morphological changes in the adipose tissue.
  • ...19 more annotations...
  • secretion of MCP-1, resistin, and other proinflammatory cytokines is increased by obesity, the adipose secretion of the anti-inflammatory protein adiponectin is decreased
  • the peroxisome proliferators- activated receptor (PPAR) family are involved in the regulation of inflammation and energy homestasis
  • natural agonists, including unsaturated fatty acids and eicosanoids
  • PPARα also regulates inflammatory processes, mainly by inhibiting inflammatory gene expression
  • upregulation of COX-2 is seen in alcoholic steatohepatitis and nonalcoholic steatohepatitis and has been directly linked to the progression of steatosis to steatohepatitis, the inhibitory effect of PPARα on COX-2 may reduce steatohepatitis
  • PPARα agonists have a clear anorexic effect resulting in decreased food intake, evidence is accumulating that PPARα may also directly influence adipose tissue function, including its inflammatory status.
  • PPARα may govern adipose tissue inflammation in three different ways: (1) by decreasing adipocyte hypertrophy, which is known to be connected with a higher inflammatory status of the tissue [3, 11, 59], (2) by direct regulation of inflammatory gene expression via locally expressed PPARα, or (3) by systemic events likely originating from liver
  • PPARγ is considered the master regulator of adipogenesis
  • Unsaturated fatty acids and several eicosanoids serve as endogenous agonists of PPARγ
  • PPARγ2, which is adipose-tissue specific
  • two different molecular mechanisms have been proposed by which anti-inflammatory actions of PPARγ are effectuated: (1) via interference with proinflammatory transcription factors including STAT, NF-κB, and AP-1
  • and (2) by preventing removal of corepressor complexes from gene promoter regions resulting in suppression of inflammatory gene transcription
  • diet-induced obesity is associated with increased inflammatory gene expression in adipose tissue via adipocyte hypertrophy and macrophage infiltration
  • PPARγ is able to reverse macrophage infiltration, and subsequently reduces inflammatory gene expression
  • Inflammatory adipokines mainly originate from macrophages which are part of the stromal vascular fraction of adipose tissue [18, 19], and accordingly, the downregulation of inflammatory adipokines in WAT by PPARγ probably occurs via effects on macrophages
  • By interfering with NF-κB signaling pathways, PPARγ is known to decrease inflammation in activated macrophages
  • Recent data suggest that activation of PPARγ in fatty liver may protect against inflammation
  • PPARs may influence the inflammatory response either by direct transcriptional downregulation of proinflammatory genes
  • anti-inflammatory properties of PPARs in human obesity
  • Nathan Goodyear on 16 Jan 12
     
    PPARs play pivotal in obesity.  PPARs appear to reduce the inflammatory cascade associated with obesity.  Downregulation of PPARs are associated with increased inflammation.  Natural PPARs include unsaturated fats and eicosanoids.
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