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Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

www.ncbi.nlm.nih.gov/...PMC303514

cortisol mineralcorticoid low potassium hypokalemia hypertension 11-betaHSD

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
  • Nathan Goodyear on 24 Apr 12
     
    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Hypertension and the cortisol-cortis... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12788832

cortisol: cortisone shuttle cortisol:cortisone cortisol:cortisone shunt cortisol cortisone 11-betaHSD 11beta-HSD2 hypertension blood pressure

shared by Nathan Goodyear on 03 Jun 14 - No Cached
  • Nathan Goodyear on 03 Jun 14
     
    Abstract only available.  Cortisol-cortisone shuttle play a role in hypertension.  Those with 11betaHSD type II defects will have elevated blood pressure due to increase in mineralcorticoids.
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