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Smile Reef

2min2x Tooth Brushing Facts for Kids - 0 views

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    Dentistry for kids promote good oral hygiene and your kids will be taught about the importance of maintaining a good oral hygiene. Children dentistry will also teach your kids how many times a day should they brush their teeth and the proper way to do it.
Nathan Goodyear

Ovarian failure and flares of systemic lupus... [Arthritis Rheum. 1999] - PubMed - NCBI - 0 views

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    Low estrogen levels in ovarian failure patients found to reduce flares in those with Lupus.  Estrogen can promote inflammation, especially high estrone levels.  It is easy to see how ovarian failure and a drop in estrogen could reduce inflammation and thus autoimmune flares.
Nathan Goodyear

Nutritional protective mechanisms against gut inflammation - 0 views

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    Nice review of inflammation originating from the gut.  This article nicely points out the pathway involving PPAR gamma and its anti-inflammatory effects in gut inflammatory conditions such as IBD. This article also specifically discusses natural compounds that activate PPAR gamma and thus reduce inflammation.  Good deep biochemical discussion of how natural therapies reduce inflammation.  
Nathan Goodyear

Metabolic management of brain cancer - 0 views

  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
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  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
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    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Association between industry affiliation and position on cardiovascular risk with rosig... - 1 views

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    read to see how pharmaceutical monies control research and "expert opinion".  Expert opinion is open to the highest bidder.  Scientific research is become adulterated to say the least.
Rachel Renner

You Can Stop Snoring Now! - 1 views

I have been looking for the best solution on How to Stop Snoring. In fact I have tried a number of anti-snoring products that all claimed to be effective yet, nothing happened. But when I tried Noi...

started by Rachel Renner on 18 Dec 12 no follow-up yet
Nathan Goodyear

Nutrition Journal | Full text | Red wine and components flavonoids inhibit UGT2B17 in v... - 0 views

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    Red wine to increase testosterone levels?  According to this study, yes.  How?  By interfering with the elimination through the UGT2B17 detoxification pathway.   Downside of this study is that this is in vitro and not in vivo.
Nathan Goodyear

Endurance exercise performance: the physiology of champions - 0 views

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    great review on performance physiology.  This article reviews  how VO2 max, lactate threshold, performance VO2, and mitochondria contribute to peak endurance performance.
Nathan Goodyear

Hypothalamic-pituitary-adrenal axis, neuroendorine factors and stress - 0 views

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    Great review on how stress effects the neuroimmunoendocrine systems.
Nathan Goodyear

HPV vaccines and cancer prevention, science versus activism - 0 views

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    This letter to the editor points out how much of "reported science" today is merely propaganda to push $$. This letter points out, scientifically, many of the flawed assumptions and problems with the Gardisil vaccine. Science is about data and evidence. The data and evidence on Gardisil is suspect at best.
Nathan Goodyear

SOGC Clinical Practice Guideline. Magn... [J Obstet Gynaecol Can. 2011] - PubMed - NCBI - 0 views

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    IV magnesium shown to be neuroprotective in those at risk for cerebral palsy.  How?  NMDA inhibition.
Nathan Goodyear

Estrogen receptor ligands in the co... [Curr Opin Investig Drugs. 2006] - PubMed - NCBI - 0 views

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    estrogen receptor beta shown to have anti-inflammatory activity.  How the message is interpreted is just as important as the message itself.
Nathan Goodyear

DORway » Aspartame & Aspartame Poisoning Information Site - 0 views

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    lengthy but extremely thorough explanation of excitotoxicity and Autism.  This is heavily referenced and should be read by all!  A good discussion on how immune stimulation in the developing brain contributes to ASD...hint: vaccines.
Nathan Goodyear

Lifestyle and nutritional imbalances associated with Western diseases: causes and conse... - 0 views

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    This study finds most "western" diseases are the result of environment and only <5% genetic. Evidence is growing that the environment is the largest contributor to disease.  The greatest environment contributor is diet. This is great, because we can change diet...if one wants too. This article also shows are current understanding on how dietary inflammation results in insulin/glucose disruption.
Nathan Goodyear

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Me... - 0 views

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    This article describes how important glutamine is as an alternative energy source in Glioblastoma. Cancer is a substrate-level dependent energy production disease. If one disrupts glycolysis as a source of energy, then many cancers will use glutamine through glutaminolysis. The cancer cells will do this through glutamate dehydrogenase and glutamate production. This will increase alpha-ketoglutarate which will then feed the substrate-level phosphorylation through the TCA cycle. This study mentioned that EGCG is a way to naturally inhibit glutamate dehydrogenase.
Nathan Goodyear

Hypnotics' association with mortality or cancer: a matched cohort study -- Kripke et al... - 0 views

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    prescription sleep aids and hypnotics associated with 3 fold increase in death.  Scary thought considering how many use sleep aids today.  First do no harm is suppose to be a physician's moto.
Nathan Goodyear

Diabetology & Metabolic Syndrome | Full text | Visceral adiposity, insulin resistance a... - 0 views

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    adipose tissue and it's biological activity contribution to cancer risk.  Good review of our current understanding on how adipose tissue increases the favorably of cancer.
Nathan Goodyear

Oxidative stress and neurodegeneration: where are we now? - Halliwell - 2006 - Journal ... - 0 views

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    Fantastic review of oxidative damage and the CNS.  This is a 2006 review of our understanding of how neurodegeneration occurs through oxidative stress and of course poor detoxification.
Nathan Goodyear

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up - 0 views

  • Leptin, secreted by adipocytes in proportion to body fat mass
  • The saturated fatty acid palmitate (16:0) induces NF-κB signaling through a TLR4-dependent mechanism
  • 18:0 (stearic) and longer saturated fatty acids as well as linolenic acid (18:3) increased proinflammatory cytokines, ER stress markers, and TLR4 activation
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  • (SOCS)-3. A member of a protein family originally characterized as negative feedback regulators of inflammation (13, 37), SOCS3 inhibits insulin and leptin signaling
  • IKKβ signaling in discrete neuronal subsets appears to be required for both hypothalamic inflammation and excess weight gain to occur during HF feeding
  • the paradoxical observation that hyperphagia and weight gain occur when hypothalamic inflammation is induced by HF feeding, yet when it occurs in response to systemic or local inflammatory processes (e.g. administration of endotoxin), anorexia and weight loss are the rule
  • , serves as a circulating signal of energy stores in part by providing feedback inhibition of hypothalamic orexigenic pathways [e.g. neurons that express neuropeptide Y and agouti-related peptide (AgRP)]
  • and stimulating anorexigenic neurons
  • signals from Toll-like receptors (TLRs), evolutionarily conserved pattern recognition molecules critical for detecting pathogens, amplified through signaling intermediates such as MyD88 activate the inhibitor of κB-kinase-β (IKKβ)/nuclear factor-κB (NF-κB), c-Jun N-terminal kinase (Jnk) and other intracellular inflammatory signals in response to stimulation by circulating saturated fatty acids
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    great read on the current understanding of how obesity and resultant inflammation disrupts hypothalamic function.
Smile Reef

Dental Care is Fun at Smile Reef - 0 views

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    Teaching children to brush and floss is a great step in helping them have healthy teeth and gums. Just as important is taking them to a pediatric dentist on a regular basis. But how many children actually get excited for every visit? Not too many. For many children, a visit to the dentist is associated with a lot of pain and discomfort.
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