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Nathan Goodyear

Frontiers | The Beneficial Effects of Physical Activity on Impaired Adult Neurogenesis ... - 0 views

www.frontiersin.org/...full

exercise neurogenesis neuroplasticity brain brain health BDNF

shared by Nathan Goodyear on 30 Nov 17 - No Cached
  • Nathan Goodyear on 30 Nov 17
     
    Neurogenesis and neuroplasticity are under epigenetic control.  Stress and aging downregulate adult neurogenesis; whereas physical activity, environment enrichment and learning/memory increase.  Check out figure 1.  Exercise increases BDNF and hence neuroplasticity.  This was a synRas mouse study.
Nathan Goodyear

Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recov... - 0 views

www.sciencedirect.com/...S0278584616302524

brain cod cannabinoids hemp oil BDNF neuroplasticity TBI brain injury

shared by Nathan Goodyear on 11 Aug 17 - No Cached
  • Nathan Goodyear on 11 Aug 17
     
    CBD increases BDNF--neuroplasticity.
Nathan Goodyear

Evaluation of the effect of caloric restriction on... [Endocrine. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19012000

BDNF obesity calorie restriction calorie-restriction neuroplasticity neurogenesis

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    In this study, weight loss through a calorie restriction diet, resulted in  an increase in BDNF.  The implications here is that obesity decreases BDNF, which is very important in neuroplasticity and neurogenesis.  Take home, obesity has negative effects on your brain. Remember that old commercial: "this is your brain on drugs".  Well, this is your brain with obesity.
Nathan Goodyear

Ketoacids? Good medicine? - 0 views

www.ncbi.nlm.nih.gov/...tacca00002-0213.pdf

Beta-hydroxybutyrate brain neurology neuroplasticity neurogenesis inflammation calorie restriction ketosis ketoacids

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Great, great read on how biochemistry effects brain function. Beta-hydroxybutyrate is an alternative fuel source for the brain in times of calorie restriction. This promotes neuroplasticity and neurogenesis without the inflammatory effects of glucose and insulin.
Nathan Goodyear

The combined effects of exercise and foods in preventing neurological and cognitive dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3258093

diet nutrition exercise BDNF omega-3 omega 3 n-3 brain derived neurotrophic factor curcumin polyphenols neuroplasticity memory sugar saturated fats

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • The most prevalent types of cognitive impairments include disturbances in attention and learning and memory function
  • An association between BDNF and learning and memory was found when measuring the performance of rats on the Morris water maze task
  • exercise and BDNF have been associated with reducing depression and promoting cognitive enhancement.
  • ...3 more annotations...
  • In addition to reducing oxidative stress and inflammation, DHA serves to improve neuronal function by supporting synaptic membrane fluidity
  • Curcumin has also been shown to protect the hippocampus and to counteract learning impairment
  • insufficient DHA in the brain can compromise neuronal function with subsequent effects on a broad range of neurological and behavioral faculties.
  • Nathan Goodyear on 01 Nov 13
     
    diet and exercise increases BDNF.  Diets rich in omega 3, curcumin, and polyphenols increase BDNF and thus increase neuroplasticity and associated cognition.   In contrast, sugar and saturated fats in crease oxidative stress and worsened spatial learning.  This study is a review.  
Nathan Goodyear

DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and... - 0 views

www.ncbi.nlm.nih.gov/...PMC3208643

DHA n-3 omega 3 omega-3 fish oil cognition memory hippocampus exercise neuroplasticity BDNF brain derived neurotrophic factor lipid peroxidation

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    DHA enriched diet plus exercis improved cognition through a increase in brain derived neurotrophic factor (BDNF).  The result was increased neuroplasticity.  Additionally, they were shown to reduce hippocampal lipid peroxidation.
Nathan Goodyear

PLOS ONE: Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for T... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0031211

curcumin brain cognition neuroplasticity turmeric

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    Not only is curcumin beneficial in neuroprotection, but curcumin can aid neuroplasticity as shown in this rat model.
Nathan Goodyear

Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Syna... - 0 views

www.jneurosci.org/...14871.long

magnesium neuroplasticity brain

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Magnesium, in this study Magnesium Threonate, shown to increase neuroplasticity
Nathan Goodyear

KoreaMed Synapse - 0 views

synapse.koreamed.org/search.php

BDNF brain derived neurotrophic factor stress bipolar disorder disease neuroplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Stress plays role in BDNF levels.  A decrease in BDNF is found in bipolar patients.  Stress will reduce neuroplasticity through a reduction in BDNF.
Nathan Goodyear

DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and... - 0 views

www.ncbi.nlm.nih.gov/...PMC3208643

DHA n-3 omega 3 omega-3 BDNF brain derived neurotrophic factor neuroplasticity cognition

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Animal study finds that DHA increases BDNF increasing neuroplasticity.
Nathan Goodyear

Omega-3 fatty acid supplementation and reduction... [J Neurosurg. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20635852

n-3 omega 3 omega-3 fish oil brain neuroplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Animal model shows that n-3 intake reduced axonal injury after injury insult.  This implies a use in n-3 intake even after an insult has occured. This implies a role for n-3 in neuroplasticity.
Nathan Goodyear

Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusi... - 0 views

www.sciencedirect.com/...S0014488604004431

BDNF brain derived neurotrophic factor hippocampus memory neuroplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    BDNF promotes neurogenesis in the hippocampus.  BDNF promotes neuroplasticity.
Nathan Goodyear

Cannabidiol, neuroprotection and neuropsychiatric disorders - ScienceDirect - 0 views

www.sciencedirect.com/...S1043661816000396

CBD cannabinoids hemp oil brain neuroplasticity

shared by Nathan Goodyear on 11 Aug 17 - No Cached
  • Nathan Goodyear on 11 Aug 17
     
    CBD is neuroprotective, neuroplastic, and neurogenic. CBD reduces oxidative stresses well.
Nathan Goodyear

Regenerative potential for allopregnanolone - 0 views

pharmweb.usc.edu/...WangJ_BrainResRev57_2008.pdf

progesterone allopregnanolone hormone hormones BDNF neurodegeneration excitotoxicity Alzheimer's disease

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Progesterone and allopregnanolone shown to have neuroprotective and neurogenesis properties in the brain. BDNF was positively correlated with progesterone. So as women age, progesterone falls, as progesterone falls, then BDNF falls and neuroplasticity declines and thus we see neurodegenerative disorders. And hormones are not needed? Who are these scientists that don't read research?!
Nathan Goodyear

MicroRNAs in the Aging Female Brain: A Putative Mechanism for Age-Specific Estrogen Eff... - 0 views

endo.endojournals.org/...2795.abstract

aging female brain estrogen HRT BHRT hormone hormones menopause neurology memory Estradiol

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Estradiol appears to have an age dependent effect on the transcription of mRNA and brain neuroplasticity.  This has a future impact on the risk of cognitive decline and dementia in elderly women.  This is only the abstract, but points to one effect of early Estradiol effect on improved brain health versus late therapy.  
Nathan Goodyear

A high-fat, refined sugar diet reduces hippocam... [Neuroscience. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12088740

diet nutrition BDNF sugar saturated fat neurplasticity hippocampus memory

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    High saturated fat and sugar diet causes reduced BDNF in the hippocampus.  This is an animal model.  The effect was a reduction in spacial learning.    Dietary choice can effect the neuroplasticity and learning capacity of the hippocampus.
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

www.ncbi.nlm.nih.gov/...PMC3231808

hbot hyperbaric therapy hyperbaric brain TBI stroke neurogenesis neuorplasticity

shared by Nathan Goodyear on 18 May 17 - No Cached
  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
  • ...10 more annotations...
  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
  • Nathan Goodyear on 18 May 17
     
    great review of hbot, brain injury, neuroplasticity and neurogenesis.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

www.ncbi.nlm.nih.gov/...PMC3829860

hbot hyperbaric therapy hyperbaric brain concussion post concussion syndrome TBI traumatic brain injury

shared by Nathan Goodyear on 17 May 17 - No Cached
  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter [61], [62], [63], [64], has positive effect upon the myelinization and maturation of injured neural fibers [65], and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
  • ...6 more annotations...
  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration [67].
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow [58], [59], [68], [69], promote blood brain barrier integrity and reduce inflammatory reactions [28] as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
  • Nathan Goodyear on 17 May 17
     
    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

BDNF function and intracellular signaling... [Histol Histopathol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20017110

BDNF TrkB neuroplasticity brain neurons

shared by Nathan Goodyear on 23 Nov 13 - No Cached
  • Nathan Goodyear on 23 Nov 13
     
    Just the abstract is available, but this is a nice review of BDNF and TrkB signaling.
Nathan Goodyear

Cell - The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and ... - 0 views

www.cell.com/...S0092867403000357

BDNF hippocampus brain neuroplasticity memory

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    BDNF plays a role in memory and proper hippocampal function.
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