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Nathan Goodyear

A Healthy Body in a Healthy Mind-and Vice Versa-The Damaging Power of "Uncontrollable" ... - 0 views

jcem.endojournals.org/...1842.full

stress cortisol cancer health healthy wellness inflammation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    very nice article on how stress causes inflammation and creates an unhealthy environment and thus a breeding ground for disease
Nathan Goodyear

First 3D Movie of Orgasm in the Female Brain - TIME Healthland - 0 views

healthland.time.com/...-of-orgasm-in-the-female-brain

woman brain orgasm libido

shared by Nathan Goodyear on 01 Dec 11 - No Cached
  • Nathan Goodyear on 01 Dec 11
     
    Interesting read: how a women's brain progresses through an orgasm.
Nathan Goodyear

Sleep Loss Activates Cellular Inflammatory Signaling - 0 views

www.biologicalpsychiatryjournal.com/...abstract

insomnia sleep loss inflammation NF-KappaB

shared by Nathan Goodyear on 24 Jan 12 - No Cached
  • Nathan Goodyear on 24 Jan 12
     
    lack of sleep increases inflammation.  This study showed how one night of sleep disruption can stimulate NF-KappaB activation and thus inflammation.
Nathan Goodyear

CNS Spectrums: Inflammation, Glutamate, and Glia in Depression: A Literature Review - 0 views

www.cnsspectrums.com/...articledetail.aspx

inflammation depression excitotoxicity glutamate glutamic acid mood disorders

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    inflammation, glutamate excitotoxicity and depression.  A very nice review of how inflammation can remotely contribute to other arenas of dysfunction, ie. depression.
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics : Article : N... - 0 views

www.nature.com/...nrendo.2011.126.html

LPS lipopolysaccharides gut microbiota dysbiosis inflammation obesity metabolic endotoxemia health probiotics

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • gut microbes have a role in the host's metabolic homeostasis
  • lipopolysaccharide (LPS)
  • Associations between circulating LPS level, consumption of a high-fat diet and the presence of obesity and type 2 diabetes mellitus have been confirmed in humans
  • ...8 more annotations...
  • associations have been proposed between high-fat diet, metabolic endotoxemia and levels of inflammatory markers (TLRs and SOCS3) in mononuclear cells
  • A link between energy intake (high-fat diet) and metabolic endotoxemia has also been described
  • high-fat diet induces metabolic endotoxemia in healthy individuals.
  • metabolic endotoxemia is associated with systemic and adipose tissue inflammation in pregnant women with obesity
  • A growing amount of evidence indicates that changes in the integrity of the intestinal barrier occur both in the proximal and the distal part of the gut, which can contribute to the entrance of LPS into the systemic circulation
  • intestinal endocannabinoid system
  • The low-grade systemic inflammation that characterizes the obese phenotype is controlled by peptides that are produced in the gut. These peptides are influenced by the presence or absence of the gut microbiota
  • these findings suggest that the gut microbiota modulates the biological systems that regulate the availability of nutrients, energy storage, fat mass development and inflammation in the host, which are all components of the obese phenotype
  • Nathan Goodyear on 18 Jan 12
     
    good look of how the the gut health, or lack there of, can influence energy homeostasis and contribute to obesity.  This article points to the presence of LPS playing a role in metabolic endotoxemia.  It does discuss the importance of the microbiota and their possible role in the low-grade systemic inflammation condition that is obesity.
Nathan Goodyear

Gut flora and inflammation - 0 views

dl-web.dropbox.com/...obita%20and%20inflammation.pdf

gut flora microbiota inflammation obesity metabolic endotoxemia weight-loss overweight LPS

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    great review article of the current understanding on how the gut microbiota can influence energy homoestasis resulting in inflammation and obesity
Nathan Goodyear

Adipose Tissue Inflammation in Obesity and Metabolic Syndrome - - Satoshi Nishimura - D... - 0 views

www.discoverymedicine.com/...obesity-and-metabolic-syndrome

inflammation obesity metabolic syndrome fat adipose tissue innate immune system humoral

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Activation of inflammatory pathways in adipocytes impairs triglyceride storage and increases release of free fatty acids, an excess of which is known to induce insulin resistance in muscle and liver
  • recent studies have shown that large numbers of macrophages infiltrate obese adipose tissue,
  • It has been postulated that a paracrine loop involving free fatty acids and inflammatory cytokines establishes a vicious cycle between adipocytes and macrophages that propagates the inflammation
  • ...5 more annotations...
  • not only does interrupting the accumulation of macrophages within obese adipose tissue suppresses adipose inflammation in various animal models, it also ameliorates systemic insulin resistance and metabolic abnormalities, suggesting macrophages are key effector cells involved in adipose inflammation
  • activation of the leukocyte adhesion cascade, a hallmark of inflammation
  • Thus, obese visceral adipose tissue is clearly a site of chronic inflammation
  • CD8+ T cells within obese adipose tissue induce activation and migration of monocytes/macrophages, and in cooperation with the adipose tissue, they also induce macrophage differentiation. At the same time, obese adipose tissue activates CD8+ T cells, creating a vicious cycle involving CD8+ T cells, macrophages, and obese adipose tissue that propagates local inflammation
  • In obese adipose tissue there is a shift to dominance of CD8+ and TH1 T cells, which appears to propagate inflammation
  • Nathan Goodyear on 21 Dec 11
     
    fascinating read how the immune system and resultant inflammation results in obesity.
Nathan Goodyear

Figure 4 : Adipocyte dysfunctions linking obesity to insulin resistance and t... - 0 views

www.nature.com/...nrm2391_F4.html

obesity insulin resistance diabetes inflammation TNF-alpha

shared by Nathan Goodyear on 22 Dec 11 - No Cached
  • Nathan Goodyear on 22 Dec 11
     
    nice diagram of how inflammation, particularily TNF-alpha in this case, promotes insulin resistance
Nathan Goodyear

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC2886982

obesity insulin resistance diabetes inflammation adipocyte dysfunction adipose tissue

shared by Nathan Goodyear on 22 Dec 11 - No Cached
  • Nathan Goodyear on 22 Dec 11
     
    Great explanation of current understanding of how adipocyte dysfunction leads to inflammation, increase FFA, insulin resistance, obesity, and associated inflammatory conditions such as diabetes
Nathan Goodyear

Fatty acid-induced mitochondrial uncoupling in ... [Diabetologia. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17712547

FFA free fatty acids mitochondria insulin resistance type II diabetes inflammation obesity adipose tissue adipocytes

shared by Nathan Goodyear on 22 Dec 11 - No Cached
  • Nathan Goodyear on 22 Dec 11
     
    how increase FFA uncouples mitochondria.  Role in development of insulin resistance and type II diabetes
Nathan Goodyear

Figure 1 : Adipocyte dysfunctions linking obesity to insulin resistance and t... - 0 views

www.nature.com/...nrm2391_F1.html

obesity insulin resistance diabetes adipose tissue inflammation TNF-alpha FFA

shared by Nathan Goodyear on 22 Dec 11 - No Cached
  • Nathan Goodyear on 22 Dec 11
     
    nice diagram of how adipocyte dysfunction leads to inflammation and insulin resistance, and increase FFA.
Nathan Goodyear

JCI - Inflammation and insulin resistance - 0 views

www.jci.org/29069

inflammation insulin resistance obesity IR overweight weight-loss

shared by Nathan Goodyear on 10 Jan 12 - No Cached
  • Nathan Goodyear on 10 Jan 12
     
    How does inflammation cause insulin resistance?  This in-depth paper helps to explain the current understanding.   More and more obesity is part of a growing inflammatory epidemic.
Nathan Goodyear

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in... - 0 views

endo.endojournals.org/...5340.full

LPS lipopolysaccharides inflammation obesity NF-KappaB insulin resistance IR

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade.  This plays a key role in the obesity epidemic.
Nathan Goodyear

Endoplasmic Reticulum Stress: Another Link Between Obesity and Insulin Resistance/Infla... - 0 views

diabetes.diabetesjournals.org/...518.full

endoplasmic reticulum stress obesity insulin resistance overweight weight-loss inflammation

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    This article discusses how endoplasmic reticulum stress contributes to obesity.
Nathan Goodyear

PPARs, Obesity, and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC1783744

PPARs PPAR obesity overweight weight-loss lipid metabolism

shared by Nathan Goodyear on 05 Jan 12 - No Cached
  • Nathan Goodyear on 05 Jan 12
     
    PPARs and how they regulate lipid metabolism.  PPARs play a critical role in obesity and inflammation
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Re: How the case against the MMR vaccine was fixed | BMJ - 0 views

www.bmj.com/...-against-mmr-vaccine-was-fixed

Dr. Wakefield MMR vaccines vaccinations colitis

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    Microbiologist defends Dr. Wakefield.  Found no intent to misrepresent facts of colitis.
Nathan Goodyear

thyroid disease and the heart - 0 views

www.ncbi.nlm.nih.gov/...v084p00455.pdf

thyroid disease heart T3 T4 thyroxine try-idodothyronine

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    nice review of how thyroid disease effects cardiac function. Notice the author of this paper describes "thy- roxine (T4) which is a prohormone and tri-iodothyronine (T3) which acts as the final mediator".
Nathan Goodyear

Cortisol, serotonin and depression: all stressed out? - 0 views

bjp.rcpsych.org/...99.full

stress cortisol saliva salivary depression 5-HTP tryptophan

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    Some with depression are found to have elevated salivary cortisol and others are not.  Likewise, some with depression have low serotonin and others do not.  The point is that the biochemistry of depression is complex and cortisol, serotonin, 5-HTP, tryptophan all may play a role in an individuals "depression".   One thing not included is the out.  How are these individuals metabolizing their cortisol?  As the author stated, some are hyper secretors of cortisol; why not hyper metabolizers?  Weibe has shown many are.
Nathan Goodyear

Access : Nonalcoholic fatty liver disease: Microbiota in the pathogenesis of systemic a... - 0 views

www.nature.com/...nrendo.2012.25.html

fatty liver disease NAFLD non-alcoholic fatty liver inflammation dysbiosis metabolic

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    Fascinating read of how inflammation as a direct result of dysbiosis in the gut contributes to the progression of NALFD.
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