Group items tagged

Efficacy vs effectiveness.  Efficacy is defined as does the vaccine work.  Effectiveness is defined as does the vaccination help people.

Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.

review really destroys the efficacy of long-term shingles vaccine.

Head to head study of SAMe and imipramine for major depression found SAMe to be equivalent in efficacy to imipramine, but with fewer side effects.

curcumin found to be statistically similar to fluoxetine in depression;  In combination there is an adjuvant effect to increase the efficacy.

The glucose ketone index shown to predict dietary metabolic success. In humans with brain cancer-- the target is 1.  The glucose and ketone (betahydroxybutyrate) should be measured 2-3 hours postprandial twice daily.

Quercetin inhibits HSP70 and improves efficacy of HT in thyroid cancer in vitro and in vivo studies.

Tylenol blunts immunotherapy treatment efficacy.

How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.

probiotic treatment has efficacy against active GI infection with cryptosporidium.

IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.

Cochrane review published in 2010 on the efficacy of the flu vaccine.  It doesn't work!.  Add that it adds additional cases of Guillain-Barre Syndrome and the question should be what are we doing to ourselves.

data on androgen therapy in women is sparse at best.  The conclusion here is suspect: "evidence supports the short-term efficacy and safety of high physiological doses of T" for women with with hypoactive sexual desire, yet the same authors recommend against long-term therapy.  How do those 2 go together???  They don't.  Support with physiologic Testosterone when appropriate testing reveals low T and symptoms support the same.  This is a practice guideline that lacks evidence to strongly back it up because so little evidence exists.  Practice guidelines are for lazy physicians.

nice review on Arginine + citrulline in ED.  Data is limited, but studies suggest improvement with individual therapy.  

This study found that herbal supplements are not what they claim to be.  The problem here is they didn't publish the companies that were found to be dishonest and then presenting this as a broad represetntation of the industry.  That is intellectual malpractice.  Herbs have observation of thousands of years of their efficacy.  Some companies choose to skimp and falsify components for profit.  This might be the cause of the difference between a $5 bottle of herbs from WalMart and a $50 dollar from a reputable supplier.  This by no means invalidates herbs.

Phytosphingosine (PS) to treat acne.

DHA (omega 3) with paclitaxel (chemotherapy) increased efficacy by 61 x

Omega-3 supplementation reduces chemotherapy toxicity and may increase survival

Great article on the detriment of prescription stimulants for cognitive enhancement.  The authors describe an inverted "U" efficacy curve.

advanced, end-stage cancer treated in few patients with IV alpha lipoic acid, oral LDN, and hydroxycitrate--case study presentation.  The therapies were well tolerated without toxicity.  The authors concluded that the therapy "enhances the efficacy" of the chemotherapy.