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Nathan Goodyear

A Vitamin B-12 Supplement of 500 μg/d for Eight Weeks Does Not Normalize Urin... - 0 views

jn.nutrition.org/...142.abstract

vitamin B12 B12 vitamin vitamins

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    current vitamin B12 recommendations are too low.  Proper vitamin B12 biomarker testing reveals this fact. The problem is most people fall prey to the lack of knowledge behind simple serum levels.  Simple B12 serum levels are woefully inadequate. Insurance would rather one stay with inadequate testing to save money, rather than actually read the science to learn about new testing.
Nathan Goodyear

Vitamin Intervention for Stroke Prevention Trial - 0 views

stroke.ahajournals.org/...2404.full

homocysteine vitamin B12 folic acid VISP stroke prevention vitamins

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.
Nathan Goodyear

Hyperhomocysteinemia, deep vein thrombosi... [J Formos Med Assoc. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17908667

vitamin B12 homocysteine DVT blood clots MS methionine synthase metformin DM diabetes insulin resistance IR

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Vitamin B12 deficiency will decrease methionine synthase activity, which will result in elevated homocysteine and the risk of DVT increases as a result.  In this article, the cause of the vitamin B12 depletion was metformin.  Diabetics and those with insulin resistance are already at an increased risk of blood clots.
Nathan Goodyear

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction - NEJM - 0 views

www.nejm.org/...NEJMoa055227

NORVIT trial homocysteine vitamin B12 B6 folic acid CVD cardiovascular disease MI stroke strokes events

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.
fnfdoc

How Bad Vitamin B12 Deficiency | Your Health Our Priority - 0 views

www.fnfdoc.com/...bad-vitamin-b12-deficiency

Health Vitamin B12 Deficiency Treatment

shared by fnfdoc on 01 May 18 - No Cached
  • fnfdoc on 01 May 18
     
    Vitamin b12 called cobalamine, important for vital functions in body, like maintenance. Deficiency cause malnutrition and digestion problems. Treatments including supplements, injections and vitamins regulatory measures.
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4864764

vitamin C IV vitamin C hypertension vitamin B12 blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
  • ...6 more annotations...
  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
  • Nathan Goodyear on 14 Aug 17
     
    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Effect of Homocy... - 0 views

jama.jamanetwork.com/article.aspx

Folic acid folate vitamin B12 B6 CVD cardiovascular events homocysteine The swiss heart study

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    This is a very good study.  Folic acid, Vitamin B12 and Vitamin B6 was found to lower Cardiovascular events through lowering homocysteine levels.  
Nathan Goodyear

Insulin resistance and endothelial function are improved after folate and vitamin B12 t... - 0 views

eje-online.org/...483.full.pdf+html

metabolic syndrome vitamin B12 vitamins Folic acid IR insulin resistance endothelial dysfunction homocysteine

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12 and Folic acid improves insulin resistance, endothelial dysfunction, and reduces homocysteine levels by 28% in those with metabolic syndrome.
Nathan Goodyear

Vitamin B12 supplementation improves rates of sustained viral response in patients chro... - 0 views

gut.bmj.com/...gutjnl-2012-302344

vitamin B12 vitamins hepatitis C HCV

shared by Nathan Goodyear on 01 Aug 12 - No Cached
  • Nathan Goodyear on 01 Aug 12
     
    Vitamin B12 shown to be beneficial adjunct to hepatitis C therapy.
Nathan Goodyear

JAMA Network | JAMA | Proton Pump Inhibitor and Histamine 2 Receptor Antagonist Use and... - 0 views

jama.jamanetwork.com/article.aspx

PPI proton pump inhibitor vitamin B12 vitamins minerals prescription drugs

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    PPI therapies and Histamine Rc blockers associated with increased vitamin B12 deficiency.
Nathan Goodyear

Serum B12 & Neuropsychiatric (Febuary 2011) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...b12psych0211.html

b12 neuropsychiatric

shared by Nathan Goodyear on 25 Feb 11 - No Cached
  • Nathan Goodyear on 25 Feb 11
     
    B12 for neuropsychiatric conditions
Nathan Goodyear

JAMA Network | JAMA | Destruction of Vitamin B12 by Ascorbic Acid - 0 views

jama.jamanetwork.com/article.aspx

vitamin C vitamin C B12 vitamins

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    old study finds oral vitamin C destroyed substantial amount of B12.  This is the reason vitamin B 12 is given when vitamin C is given.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/179/1/35.full.pdf - 0 views

joe.endocrinology-journals.org/...35.full.pdf

homocysteine Testosterone low T low Testosterone testosterone replacement therapy B12 folic acid

shared by Nathan Goodyear on 25 Jul 16 - No Cached
  • Nathan Goodyear on 25 Jul 16
     
    study finds no correlation between gonadotropin levels, increasing Testosterone levels and homocysteine levels.  The treatment group had significant decline in folic acid and B12 after 6 months of treatment and this correlated with the decline in homocysteine.
Nathan Goodyear

Intravenous methylcobalamin treatment for uremic ... [Intern Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10411351

IV intravenous therapy vitamin B12 neuropathy diabetic neuropathy peripheral neuropathy

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    IV vitamin B12 shown to safe and effective treatment of neuropathy in diabetic patients.
Nathan Goodyear

Effects of metformin with or without supplemen... [Diabetes Care. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19933994

metformin PCOS diabetes DM homocysteine Folic acid folate vitamin B12 CoQ10 drug-induced nutrient depletion

shared by Nathan Goodyear on 06 Feb 12 - No Cached
  • Nathan Goodyear on 06 Feb 12
     
    metformin shown to result in increased homocysteine through depletion of folate. Metformin is also known to deplete vitamin B12 and CoQ10.  
Nathan Goodyear

Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels - NEJM - 0 views

www.nejm.org/...NEJMoa011364

homocysteine vitamin B12 B6 folic acid folate coronary angioplasty

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    lowering homocysteine reduced the rate of coronary restenosis.  A combination of folic acid, Vitamin B12, and Vitamin B6 were used to lower homocysteine.
Nathan Goodyear

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease - NEJM - 0 views

www.nejm.org/...NEJMoa060900

HOPE-2 trial vitamin B12 Vitamins B6 folic acid folate homocysteine CVD cardiovascular disease events stroke MI

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, B6, and folic acid shown to lower homocysteine levels and decreased the incidence of stroke.  However, overall mortality and CVD deaths were not.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Targeting Synaptic Dysfunction in Alzheimer's Disease by Administering a Specific Nutri... - 0 views

iospress.metapress.com/...gg33167h46757165

alzheimer's disease Alzheimer's disease DHA EPA Folate B12 B6 vitamin E C vitamins brain

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Combination of DHA, EPA, choline, phospholipids, Folate, B12, B6, vitamin C and E, and selenium improves memory and cognitive function in those with mild Alzheimer's disease.
Nathan Goodyear

Nutrition and Depression: The Role of Folate : The Basis for Folate Deficiency in Depre... - 0 views

www.medscape.com/...431514_5

folate folic acid B12 depression

shared by Nathan Goodyear on 08 Dec 10 - No Cached
  • Nathan Goodyear on 08 Dec 10
     
    24% of patients with depression had low folate levels; 13% had low B12
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