short term fasting and ketosis provides neuroprotection and preserves mitochondria in animal TBI study. This study found preventative effects of the ketones.
TBI results in hormone disruption in 25-69% of those effected. The major cause is a pituitary/neuro-endocrine effect. This has been described since the early 20th century.
This study finds that AGE, advanced glycation end products, play a significant role in free radical generation and neurodegenerative disease.
Quote: "... pharmacologoical approaches which break the vicious cycle of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD. These approaches include AGE- inhibitors, antioxidants, and anti-inflammatory substances which prevent radical production." They focus on the pharmacological, how about the natural first?
Mouse study finds that DHT metabolite provides negative feedback to HPA via 3beta androstaendiol. What is interesting is that this signaling occurred through ER beta. Androgen signaling processed through estrogen receptors.
Postmenopausal cognitive decline is a common complaint. Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline. This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein. This amyloid Beta protein is associated with damage found in Alzheimer's.