Skip to main content

Home/ Seasons Wellness/ Group items tagged receptor

Rss Feed Group items tagged

Nathan Goodyear

Estriol treatment ameliorates disease in male... [J Neuroimmunol. 2004] - PubMed - NCBI - 0 views

  •  
    Estriol found to be beneficial in experimental model of MS called EAE.  The effect would be through E3's preferential binding to ERbeta.  This study finds benefit in men and women.
Nathan Goodyear

Decreased estrogen receptor-alpha expressio... [Acta Neuropathol. 2003] - PubMed - NCBI - 0 views

  •  
    Estrogen Receptor alpha expression is decreased in the nucleus of hippocampus in Alzheimer's disease.
Nathan Goodyear

LIGAND STRUCTURE-DEPENDENT ACTIVATION OF ESTROGEN RECEPTOR α/Sp BY ESTROGENS ... - 0 views

  •  
    xenoestrogens are estrogen receptor agonists.  This is a good discussion of there interaction with xenoestrogens and particularly ER alpha.
Nathan Goodyear

On Estrogen, Cholesterol Metabolism, and Breast Cancer - NEJM - 1 views

  •  
    Cholesterol metabolite linked to increased breast cancer risk through estrogen receptor signaling.  The metabolite is 27-hydorxycholesterol.
Nathan Goodyear

Mechanisms mediating androgen receptor reactivation after castration - 0 views

  •  
    In cases of CRPC, there is endogenous androgen synthesis from weaker adrenal androgens.  Also, the authors point to a unregulated AR sensitivity in the lower androgen environment created by ADT.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

  •  
    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
Nathan Goodyear

Dihydrotestosterone may inhibit hypothalamo-pi... [Neurosci Lett. 2004] - PubMed - NCBI - 0 views

  •  
    Mouse study finds that DHT metabolite provides negative feedback to HPA via 3beta androstaendiol.  What is interesting is that this signaling occurred through ER beta.  Androgen signaling processed through estrogen receptors.
Nathan Goodyear

The dialectic role of progesterone. [Maturitas. 2009] - PubMed - NCBI - 0 views

  •  
    knowledge of progesterone and its metabolites are important in the use of hormones.  As the authors concluded here: "natural steroids should not be disparaged...an update on endocrinological knowledge and experience is rather mandatory for gynecologists".  There in lies the problem.  The IOM has shown that the average physician practices at a level of 17 years behind the current scientific knowledge and the environment created by medical governing bodies discourages questions, so as to protect the system.
Nathan Goodyear

Genotoxic metabolites of estradio... [J Steroid Biochem Mol Biol. 2003] - PubMed - NCBI - 0 views

  •  
    study finds estrogen metabolites are involved in carcinogenesis through the production of toxic metabolites 3,4 quinones.  The presence of Estrogen receptors were associated with increased tumor growth. ER was in fact ER alpha.  What is interesting is that ER beta is not expressed these ERKO animals.  This again points to ER beta's anti proliferative action.
Nathan Goodyear

Estrogen receptor beta in the prostate - 0 views

  •  
    ER beta plays an important role in the prostate.  Loss of ER beta expression in the prostate has been shown to promote carcinogenesis.  In addition, 3-beta androstanediol, a DHT metabolite has been shown to signal through ER beta.
Nathan Goodyear

Mechanisms of Estrogen Action - 0 views

  •  
    good discussion of estrogen receptors and their role of estrogen signaling transmission.This article goes deep into coregulators, corepressors, cofactors, agonists, antagonists...
Nathan Goodyear

Comparison of the ligand binding specificity a... [Endocrinology. 1997] - PubMed - NCBI - 0 views

  •  
    DHT metabolite 3-beta androstanediol has ER affinity, not AR affinity.
Nathan Goodyear

Estrogen receptor β2 and β5 are associated with poor prognosis in prostate ca... - 0 views

  •  
    Study finds that ER beta isomer type 2 and 4 increased prostate cancer aggressiveness.
Nathan Goodyear

The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast... - 0 views

  •  
    Great article!!  Nice discussion of the complexity of hormones.  Women on aromatase inhibitors can make estrogen from Testosterone.  This is important with estrogen sensitive cancer as in breast cancer.  This will occur via alternative pathways: Testosterone to DHT via 5 alpha reductase and then DHT to 3 beta androstanediol via 3 beta HSD.  3 beta androstanediol is a male hormone metabolite that binds to estrogen receptors.  The affinity is less than Estradiol, but appears to have a higher affinity for ER beta over ER alpha. 
Nathan Goodyear

Comparative Studies of the Estrogen Receptors β and α and the Androgen Recept... - 0 views

  • ER-β is predominately immunolocalized in basal cells and to a lesser extent in stromal cells of the morphologically normal human prostate
  • ER-α is detected in stromal cells and rarely in basal cells of the normal gland
  • AR was predominately localized in the nuclei of differentiated secretory cells and variably in basal cells of the normal acinar/duct unit as well as in stromal cells
  • ...9 more annotations...
  • Hall and colleagues44 have reported that ER-β functions as a transdominant inhibitor of ER-α transcription and that it acts to decrease overall cellular sensitivity to estradiol
  • The expression of ER-β was diminished in high-grade dysplasias when compared to normal glands and lower grade lesions.
  • The transition from normal to low/moderate dysplastic glands in the peripheral zone was marked by the appearance of ER-β homogeneously immunostained nuclei in secretory as well as basal cells with no changes in the localization of the other receptors.
  • proliferative signals mediated by AR in basal cells or by ER-α and AR in stromal cells may be opposed by the purported growth-inhibitory action of ER-β25, 26, 27, 28 localized in basal cells.
  • The diminution of ER-β expression in high-grade dysplasias and grade 4/5 cancers may be therefore related to the alteration of DNA methylation pattern in CpG islands of the promoter, resulting in down-regulation of the receptor at the transcriptional level
  • based on the proposed anti-proliferative function of the receptor,25, 26, 27, 28 the presence of ER-β in secretory cells of low/moderate-grade lesions may represent a transient abortive attempt to counter growth of these cells
  • the attrition of receptor-positive basal cells in the high-grade dysplasias may signify a continuing loss of growth inhibitory function mediated by ER-β in these precursor lesions
  • Our findings in prostate therefore differ from those reported for human colon cancer in which Folley and colleagues48 demonstrated that a selective loss of ER-β protein but not receptor message expression occurs in these neoplasms
  • Our findings therefore differed from those of Bonkhoff and colleagues33 who found immunostaining for the receptor in high-grade dysplasias and grade 4/5 carcinomas. Using in situ hybridization these authors also reported that a high percentage of dysplasias and carcinomas in their study contained cells that expressed ER-α message
  •  
    Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.  

    In contrast, androgen receptors appeared to be equally expressed across all.
Nathan Goodyear

Estrogen receptor-β: Implications for the prostate gland - Chang - 1999 - The... - 0 views

  •  
    ER beta and the prostate.  Older review.
Nathan Goodyear

Estrogen Receptor β in Prostate Cancer: Brake Pedal or Accelerator? - 0 views

  •  
    Great article on ER beta and the prostate.  ER alpha expression is very important in the development of the prostate.  IN that instance, ER beta is down regulated.  In prostate cancer generation, ER beta expression in the epithelium is lost.
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  •  
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

Expression of estrogen receptor β in prostate carcinoma cells inhibits invasi... - 0 views

  •  
    Study finds that ER beta inhibits invasion, proliferation and actually triggers cell death of prostate cancer cells.  This fits with the other data that loss of ER beta promotes carcinogenesis.
1 - 20 of 93 Next › Last »
Showing 20 items per page