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Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H an... - 0 views

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    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Pla... - 0 views

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    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
Nathan Goodyear

Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ... - 0 views

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    Androgen receptors may be associated with bladder cancer progression.  This study finds AR up regulates Epidermal growth factor in bladder cancer cells.
Nathan Goodyear

Expression of androgen and oestrogen receptors and its prognostic significance in uroth... - 0 views

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    Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.
Nathan Goodyear

Loss of androgen receptor expression is not associated with pathological stage, grade, ... - 0 views

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    multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.
Nathan Goodyear

Expression and significance of androgen receptor coactivators in urothelial carcinoma o... - 0 views

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    This study focused on coactivators in bladder cancer.  Although, the study found that AR expression was inversely associated with advancing bladder cancer stage--This is opposite from the positive correlation with Prostate Cancer.  
Nathan Goodyear

Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals - 0 views

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    Animal study finds that Androgen Receptors play role in bladder cancer development and progression in men.
Nathan Goodyear

Estrogen Receptor β Expression Is Associated with Tamoxifen Response in ERα-N... - 0 views

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    Increased survival in those with ER beta + and ER alpha -.  Early relapse was associated with lack of ER beta expression.  ER beta is transcribed from a different genomic location than ER alpha.  
Nathan Goodyear

Estradiol Binds to Insulin and I... [Front Endocrinol (Lausanne). 2014] - PubMed - NCBI - 0 views

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    Interesting.  Estradiol competes with Insulin for insulin receptors.  Estradiol has a high affinity for these Insulin receptors.  This has huge implications on HRT in women and men for that matter.
Nathan Goodyear

Cadmium - a metallohormone? - 0 views

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    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

Efficacy of the Progesterone Receptor Antagonist Mifepristone for Palliative Therapy of... - 0 views

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    Another study points to mifepristone in the benefit of progesterone receptor blockade in late stage cancer.
Nathan Goodyear

A novel perspective for Alzheimer's disease... [J Alzheimers Dis. 2011] - PubMed - NCBI - 0 views

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    Alzheimer's model finds that amyloid-beta supresses vitamin D receptor.  This study found that vitamin D therapy protected neurons by up regulating vitamin D receptors.  This prevented cytotoxicity and cell death.
Nathan Goodyear

Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulato... - 0 views

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    Studies in breast cancer and prostate cancer have revealed different effects by ER alpha vs ER beta.  It is no surprise that the same effects are found in ovarian cancer.  This study found ER alpha antagonists and ER beta agonists "significantly" suppressed growth in the ovarian cancer cell lines SKOV3 and OV2008.  Also, ER alpha agonist and ER beta antagonist "significantly" increased growth in the same cell lines.  These findings point to in increased proliferation with ER alpha and decreased with ER beta.  This is consistent with breast and prostate cancer also.
Nathan Goodyear

Estriol treatment ameliorates disease in male... [J Neuroimmunol. 2004] - PubMed - NCBI - 0 views

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    Estriol found to be beneficial in experimental model of MS called EAE.  The effect would be through E3's preferential binding to ERbeta.  This study finds benefit in men and women.
Nathan Goodyear

Decreased estrogen receptor-alpha expressio... [Acta Neuropathol. 2003] - PubMed - NCBI - 0 views

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    Estrogen Receptor alpha expression is decreased in the nucleus of hippocampus in Alzheimer's disease.
Nathan Goodyear

LIGAND STRUCTURE-DEPENDENT ACTIVATION OF ESTROGEN RECEPTOR α/Sp BY ESTROGENS ... - 0 views

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    xenoestrogens are estrogen receptor agonists.  This is a good discussion of there interaction with xenoestrogens and particularly ER alpha.
Nathan Goodyear

On Estrogen, Cholesterol Metabolism, and Breast Cancer - NEJM - 1 views

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    Cholesterol metabolite linked to increased breast cancer risk through estrogen receptor signaling.  The metabolite is 27-hydorxycholesterol.
Nathan Goodyear

Mechanisms mediating androgen receptor reactivation after castration - 0 views

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    In cases of CRPC, there is endogenous androgen synthesis from weaker adrenal androgens.  Also, the authors point to a unregulated AR sensitivity in the lower androgen environment created by ADT.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

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    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
Nathan Goodyear

Dihydrotestosterone may inhibit hypothalamo-pi... [Neurosci Lett. 2004] - PubMed - NCBI - 0 views

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    Mouse study finds that DHT metabolite provides negative feedback to HPA via 3beta androstaendiol.  What is interesting is that this signaling occurred through ER beta.  Androgen signaling processed through estrogen receptors.
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