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https://www.thefastleanpro.us/ - 0 views

www.thefastleanpro.us

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
fitspresso

https://www.sightcare-co.com/ - 0 views

www.sightcare-co.com

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
Nathan Goodyear

Turmeric | GreenMedInfo | Substance | Natural Medicine | Alternative Medicine - 0 views

www.greenmedinfo.com/...turmeric

natural medicine alternative Turmeric

shared by Nathan Goodyear on 13 Jun 11 - No Cached
  • Nathan Goodyear on 13 Jun 11
     
    US National lIbrary of Medicine list of research on Turmeric
Nathan Goodyear

Curcumin | GreenMedInfo | Substance | Natural Medicine | Alternative Medicine - 0 views

www.greenmedinfo.com/...curcumin

natural medicine alternative curcumin turmeric

shared by Nathan Goodyear on 13 Jun 11 - No Cached
  • Nathan Goodyear on 13 Jun 11
     
    US National Library of Medicine list of research on Curcumin
Nathan Goodyear

Inflammation and Native American medicine: the role of botanicals - 0 views

ajcn.nutrition.org/...339.long

inflammation native Americans medicine botanicals herbs medicinal natural

shared by Nathan Goodyear on 30 Nov 14 - No Cached
  • Nathan Goodyear on 30 Nov 14
     
    review of medicinal botanicals used by native Americans.
Nathan Goodyear

Alzheimer's Disease: The Pros and Cons of Pharmaceutical, Nutritional, Botanical, and S... - 0 views

www.altmedrev.com/...223.pdf

BDNF Huperzine-A Alzheimer's disease

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    I like the inclusion of western medicine and more "natural" medicine in the biochemical treatment of Alzheimer's disease. Brief review of BDNF.
Nathan Goodyear

Light Therapy More Effective Than Prozac in Patients With Major Depression | Natural Me... - 0 views

www.naturalmedicinejournal.com/...ozac-patients-major-depression

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shared by Nathan Goodyear on 15 Apr 16 - No Cached
  • Nathan Goodyear on 15 Apr 16
     
    new study finds that light therapy therapy for major depression outperformed prozac therapy.  This study was short at only 8 weeks.
Nathan Goodyear

Astaxanthin: A Review of the Literature | Natural Medicine Journal - 0 views

naturalmedicinejournal.com/...astaxanthin-review-literature

astaxanthin natural alternative medicine natural medicine

shared by Nathan Goodyear on 25 Sep 15 - No Cached
  • Nathan Goodyear on 25 Sep 15
     
    Nice review on astaxanthin.
Nathan Goodyear

Asian Journal of Andrology - Efficacy and safety of Chinese herbal medicine for benign ... - 0 views

www.nature.com/...aja2012173a.html

chinese herbal medicine BPH benign prostatic hypertrophy

shared by Nathan Goodyear on 26 Aug 13 - No Cached
  • Nathan Goodyear on 26 Aug 13
     
    Study doesn't find alot of "good" evidence to support Chinese herbal medicine in BPH.  However, the author states: "Before the introduction of conventional medication and surgery to China, the Chinese had solely relied on CHM to treat BPH for more than three thousand years".  That is 3,000 years of observational data that is being tossed out the window.
Nathan Goodyear

Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer cancer stem cells milk thistle silymarin ascorbic acid bee propolis CAPE glycolytic inhibitor natural

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
  • Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
  • ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
  • ...26 more annotations...
  • mitochondrial biogenesis may be a key driver of the CSC phenotype
  • Our results indicate that increased mitochondrial oxidative stress and high NADH levels are both key characteristics of the CSC metabolic phenotype
  • high levels of NAD(P)H auto-fluorescence are known to be a surrogate marker for mitochondrial “power”, high OXPHOS capacity and increased ATP production
  • CSCs may be strictly dependent on NAD(P)H to maintain their enhanced mitochondrial function
  • an intact NAD+ salvage pathway is strictly required for mammosphere formation, supporting our results using NAD(P)H auto-fluorescence, which enriched CSC activity by more than 5-fold.
  • Since glycolysis is especially critical for maintaining the TCA cycle, OXPHOS and overall mitochondrial function, we next assessed the effects of known glycolytic inhibitors
  • we show that two other natural products that function as effective glycolysis inhibitors, also inhibited mammosphere formation. More specifically, vitamin C (ascorbic acid), which induces oxidative stress and inhibits the activity of GAPDH (a key glycolytic enzyme) [17], also inhibited mammosphere formation, with an IC-50 of 1 mM (Figure 7B). Therefore, vitamin C was ~10 times more potent than 2-DG at targeting CSC propagation
  • silibinin (the major active constituent of silymarin, an extract of milk thistle seeds) [18], which specifically functions as an inhibitor of glucose uptake, blocked mammosphere formation, with an IC-50 between 200 and 400 µM
  • caffeic acid phenyl ester (CAPE), a key component of honey-bee propolis, has potent anti-cancer properties
  • Propolis has a strong history of medicinal use, dating back more than 2,000 years
  • Because of it aromatic ring structure (Figure 8), we speculated that CAPE might function as a potent inhibitor of oxidative mitochondrial metabolism
  • CAPE quantitatively inhibits the mitochondrial oxygen consumption rate (OCR) and, in turn, induces the onset of aerobic glycolysis (ECAR)
  • CAPE shows a clear selectivity for targeting CSCs and adherent cancer cells, relative to normal fibroblasts.
  • CAPE functions as a “natural” mitochondrial OXPHOS inhibitor, that preferentially targets the CSC sub-population. This could explain CAPE’s known anti-cancer properties
  • Our data directly shows that a small fraction of the total cell population, characterized by increased PGC1α activity, high mitochondrial ROS/H2O2 and high NADH levels, has the ability to survive and grow under anchorage-independent conditions, driving mammosphere formation
  • We highlight the utility of certain natural products, such as Silibinin, Vitamin C and CAPE, that could be used to therapeutically target CSCs. Silibinin is the major active component of silymarin, which is an extract prepared from milk thistle seeds.
  • high NADH is a property that is conserved between normal and cancerous stem cells
  • Previous studies have also shown that when non-CSCs and CSCs are both fed mitochondrial fuels (such as L-lactate or ketone bodies), that CSCs quantitatively produce more NADH in response to this stimulus
  • CSCs may be strictly dependent on NADH to maintain their enhanced mitochondrial function
  • The Noble Prize winner, Linus Pauling, was among the first to describe and clinically test the efficacy of Vitamin C, as a relatively non-toxic anti-cancer agent
  • Vitamin C has two mechanisms of action. First, it is a potent pro-oxidant, that actively depletes the reduced glutathione pool, leading to cellular oxidative stress and apoptosis in cancer cells. Moreover, it also behaves as an inhibitor of glycolysis, by targeting the activity of GAPDH, a key glycolytic enzyme.
  • Here, we show that Vitamin C can also be used to target the CSC population, as it is an inhibitor of energy metabolism that feeds into the mitochondrial TCA cycle and OXPHOS
  • Vitamin C may prove to be promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis
  • Interestingly, a breast cancer based clinical study has already shown that the use of Vitamin C, concurrent with or within 6 months of chemotherapy, significantly reduces both tumor recurrence and patient mortality
  • CAPE quantitatively reduces mitochondrial oxygen consumption (OCR), while inducing a reactive increase in glycolysis (ECAR). As such, it potently inhibits mammosphere formation with an IC-50 of ~2.5 µM. Similarly, it also significantly inhibits cell migration
  • we also demonstrate that 7 different inhibitors of key energetic pathways can be used to effectively block CSC propagation, including three natural products (silibinin, ascorbic acid and CAPE). Future studies will be necessary to test their potential for clinical benefit in cancer patients.
  • Nathan Goodyear on 08 Dec 17
     
    The future of cancer therapy is cancer stem cells.  Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells.  Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs.  The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
Nathan Goodyear

Natural products as important tyrosine kinase inhibitors - 0 views

dacemirror.ggws.net/...yin2019.pdf

natural therapy cancer tyrosine kinase natural therapies natural medicine tyrosine kinase inhibitors

shared by Nathan Goodyear on 16 Mar 21 - No Cached
  • Nathan Goodyear on 16 Mar 21
     
    Good review of some natural products that have been shown to inhibit tyrosine kinase activity.
Nathan Goodyear

Efficacy and Safety of Curcumin in Major Depre... [Phytother Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23832433

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shared by Nathan Goodyear on 01 Dec 15 - No Cached
  • Nathan Goodyear on 01 Dec 15
     
    curcumin found to be statistically similar to fluoxetine in depression;  In combination there is an adjuvant effect to increase the efficacy.
Nathan Goodyear

Natural products as important tyrosine kinase inhibitors - ScienceDirect - 0 views

www.sciencedirect.com/...S0223523419308086

natural medicine natural tyrosine kinase inhibitors cancer natural therapy natural therapies

shared by Nathan Goodyear on 11 Feb 21 - No Cached
  • Nathan Goodyear on 11 Feb 21
     
    Only abstract available.
Nathan Goodyear

Nutraceuticals in Prostate Disease: The Urologist's Role - 0 views

www.ncbi.nlm.nih.gov/...PMC2556486

prostate disease natural medicine alternative medicine herbal therapies Saw Palmetto stinging nettle quercetin BPH prostatitis prostate cancer Zinc selenium vitamin E vitamin D calcium fiber bioflavonoids

shared by Nathan Goodyear on 25 Sep 15 - No Cached
  • Nathan Goodyear on 25 Sep 15
     
    nice review of natural therapies on the prostate.
Nathan Goodyear

Induction of clinical response and remission of inflammatory bowel disease by use of he... - 0 views

www.ncbi.nlm.nih.gov/...PMC3769914

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shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    Study of natural therapies against UC are limited, but this review found statistical benefit in patients with IBD.  No induction of remission was seen.
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