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Nathan Goodyear

Homocysteine and MTHFR Mutations - 0 views

circ.ahajournals.org/...e289.full

homocysteine MTHFR CVD cardiovascular death CAD c677T A1298c

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • The most common MTHFR mutation is called the MTHFR C677T mutation
  • Another common mutation is called MTHFR A1298C
  • Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation)
  • ...4 more annotations...
  • Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
  • Regardless of whether you have an MTHFR mutation in both genes or not, the treatment for elevated homocysteine is the same—dietary intervention and supplementation with folic acid and vitamins B6 and B12
  • Overall, evidence from these studies indicates that, so long as the homocysteine level is normal, MTHFR mutations do not significantly increase the risk of heart attack or stroke
  • Studies investigating the association of MTHFR mutations and venous blood clots have been inconsistent, with some studies showing a slight association, but most studies have not shown any association
  • Nathan Goodyear on 02 Feb 15
     
    Good review of MTHFR and homocysteine.
Nathan Goodyear

Homocysteine, folate, methylation, and monoamine metabolism in depression -- Bottiglier... - 0 views

jnnp.bmj.com/228

homocysteine depression methylation Folate 5-MTHF Folic Acid psychiatry neurology

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    elevated homocysteine associated with a 2 x higher incidence of depression versus those with low homocysteine.  Methylation plays a role in depression.
Nathan Goodyear

Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels - NEJM - 0 views

www.nejm.org/...NEJMoa011364

homocysteine vitamin B12 B6 folic acid folate coronary angioplasty

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    lowering homocysteine reduced the rate of coronary restenosis.  A combination of folic acid, Vitamin B12, and Vitamin B6 were used to lower homocysteine.
Nathan Goodyear

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction - NEJM - 0 views

www.nejm.org/...NEJMoa055227

NORVIT trial homocysteine vitamin B12 B6 folic acid CVD cardiovascular disease MI stroke strokes events

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.
Nathan Goodyear

Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and durin... - 0 views

www.clinchem.org/...1738

homocysteine hypothyroid hypothryoidism

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    hypothyroid patients have higher homocysteine levels than hyperthyroid patients; Elevated homocysteine is predictive of cardiovascular disease
Nathan Goodyear

ScienceDirect - American Heart Journal : Plasma total cysteine and total homocysteine a... - 0 views

www.sciencedirect.com/...S0002870310000815

elevated homocysteine MI risk cardiac

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Fasting homocysteine was positively associated with MI risk
  • Fasting plasma concentration of total homocysteine, but not total cysteine, was positively associated with MI risk.
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine associated with MI risk
Nathan Goodyear

Plasma Homocysteine as a Risk Factor for Vascular Disease, June 11, 1997, Graham et al.... - 0 views

jama.ama-assn.org/...1775.short

homocysteine CAD cardiovascular disease risk

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia. It powerfully increases the risk associated with smoking and hypertension. It is time to undertake randomized controlled trials of the effect of vitamins that reduce plasma homocysteine levels on vascular disease risk.
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine levels increase vascular disease risk.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/179/1/35.full.pdf - 0 views

joe.endocrinology-journals.org/...35.full.pdf

homocysteine Testosterone low T low Testosterone testosterone replacement therapy B12 folic acid

shared by Nathan Goodyear on 25 Jul 16 - No Cached
  • Nathan Goodyear on 25 Jul 16
     
    study finds no correlation between gonadotropin levels, increasing Testosterone levels and homocysteine levels.  The treatment group had significant decline in folic acid and B12 after 6 months of treatment and this correlated with the decline in homocysteine.
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Plasma Total Homocysteine Level and Bone... - 0 views

archinte.jamanetwork.com/article.aspx

homocysteine folate folic acid folic acid BMD women bone mineral osteoporosis density

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    elevated homocysteine and low folic acid levels associated with decreasing BMD in women.
Nathan Goodyear

Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Horda... - 0 views

ajcn.nutrition.org/...130.full

homocysteine cardiovascular mortality CVD

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    conclusion says it all: "homocysteine is a strong predictor of both cardiovascular and non cardiovascular mortality..."
Nathan Goodyear

http://jpmph.org/upload/pdf/jpmph-45-387.pdf - 0 views

jpmph.org/...jpmph-45-387.pdf

Pb lead homocysteine

shared by Nathan Goodyear on 18 Sep 14 - No Cached
  • Nathan Goodyear on 18 Sep 14
     
    Blood lead levels correlate with homocysteine levels.  Methylation (B12, Folate, B6) plays a role regulating homocysteine levels as well. 
Nathan Goodyear

Blood Lead Is a Predictor of Homocysteine Levels: Abstract and Introduction - 0 views

www.medscape.com/...497373

lead homocysteine cardiovascular disease

shared by Nathan Goodyear on 14 Feb 11 - No Cached
  • These results suggest that homocysteine could be a mechanism that underlies the effects of lead on the cardiovascular and central nervous systems, possibly offering new targets for intervention to prevent the long-term consequences of lead exposure
  • Nathan Goodyear on 14 Feb 11
     
    Lead, homocysteine, and cardiovascular disease, oh my
Nathan Goodyear

Blood Lead Is a Predictor of Homocysteine Levels in a Population-Based Study of Older A... - 0 views

www.ncbi.nlm.nih.gov/...PMC1253706

lead homocysteine

shared by Nathan Goodyear on 16 Mar 11 - No Cached
  • These results suggest that homocysteine could be a mechanism that underlies the effects of lead on the cardiovascular and central nervous systems
  • Nathan Goodyear on 16 Mar 11
     
    your elevated homocysteine maybe be just a marker for elevated lead
Nathan Goodyear

Abstract 21277: Homocysteine and Cardiovascular Risk in Low Risk Healthy Adults - An An... - 0 views

circ.ahajournals.org/...A21277

homocysteine cardiovascular CAD disease

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Homocysteine significantlyimproves risk prediction of cardiovascular events in healthyadults
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine found to be helpful in predicting cardiovascular events in healthy adults
Nathan Goodyear

ScienceDirect - Clinical Biochemistry : Correlation between total homocysteine, low-den... - 0 views

www.sciencedirect.com/...S0009912001001874

homocysteine heart attack myocardial infarction

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • usefulness of LDL-C, HDL-C and serum total homocysteine as prognostic markers in myocardial infarction patients
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine shown to be a good prognostic marker for patients with prior heart attacks
Nathan Goodyear

HOMOCYSTEINE AND CARDIOVASCULAR DISEASE - Annual Review of Medicine, 49(1):31 - 0 views

www.annualreviews.org/...annurev.med.49.1.31

HOMOCYSTEINE cardiovascular disease CAD thromboembolism DVT artherosclerosis

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine increases risk for artherosclerosis, cardiovascular disease, and thromboembolism
Nathan Goodyear

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease - NEJM - 0 views

www.nejm.org/...NEJM199707243370403

homocysteine mortality cardiovascular disease CAD risk

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Plasma total homocysteine levels are a strong predictor of mortality in patients with angiographically confirmed coronary artery disease
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine strong predictor of mortality
Nathan Goodyear

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis -- ... - 0 views

www.bmj.com/...1202.abstract

homocysteine heart disease CAD cardiovascular DVT stroke

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • There were significant associations between homocysteine and the three diseases
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine associated with ischemic heart disease, DVT, and stroke
Nathan Goodyear

Homocysteine and Endothelial Dysfunction: A Link with Cardiovascular Disease - 0 views

jn.nutrition.org/...369.full.pdf+html

homocysteine CVD endothelial dysfunction cardiovascular disease ROS reactive oxygen species

shared by Nathan Goodyear on 25 Sep 12 - No Cached
  • Nathan Goodyear on 25 Sep 12
     
    No surprise that homocysteine is associated with vascular dysfunction, when elevated;  But the mechanism is elucidated here through ROS generation.
Nathan Goodyear

IJMS | Free Full-Text | Defective Homocysteine Metabolism: Potential Implications for S... - 0 views

www.mdpi.com/...htm

homocysteine MTHFR

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    very nice review of homocysteine pathways.
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