Group items tagged

NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.

A common tool to monitor the progression of atherosclerosis is carotid intima-medial thickness.  This meta-analysis showed that folic acid reduces carotid intimal medial thickness.

Vitamin B12, B6, and folic acid shown to lower homocysteine levels and decreased the incidence of stroke.  However, overall mortality and CVD deaths were not.

elevated homocysteine and low folic acid levels associated with decreasing BMD in women.

This is a very good study.  Folic acid, Vitamin B12 and Vitamin B6 was found to lower Cardiovascular events through lowering homocysteine levels.  

400 mcg Folic acid shown to reduce total cholesteroel and LDL-C in women and men.  Additionally, apoAI is increased.

A mixture of rhodiola, folic acid, biotin, and zinc found to improve ejaculation control in those with Premature ejaculation.

study finds no correlation between gonadotropin levels, increasing Testosterone levels and homocysteine levels.  The treatment group had significant decline in folic acid and B12 after 6 months of treatment and this correlated with the decline in homocysteine.

lowering homocysteine reduced the rate of coronary restenosis.  A combination of folic acid, Vitamin B12, and Vitamin B6 were used to lower homocysteine.

elevated homocysteine and low folic acid levels associated with increased risk of Alzheimer's disease and dementia.

Vitamin B12 and Folic acid improves insulin resistance, endothelial dysfunction, and reduces homocysteine levels by 28% in those with metabolic syndrome.

Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.

Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.

randomized study finds no difference in attention, memory in children born to mothers supplementing with DHA.  Good randomized design, but several problems.  First, did these women need supplementation.  No testing was done to determine need.  They may have needed more or none at all--the standard throw a dart on the wall and hope it sticks paradigm.  Second, Neurologcial development starts from day one, so do properly determine effect, the authors need to start support at conception or even better- before.  This follows that logic that women desiring conception should start extra folic acid 3 months prior. The literature is moving in the right direction, but they are still limiting themselves.  

great review of mitochondrial biogenesis, oxidative stress and heart failure.  

Good review of MTHFR and homocysteine.

what you eat and how many calories you eat effects you brain and your risk of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.

elevated homocysteine associated with a 2 x higher incidence of depression versus those with low homocysteine.  Methylation plays a role in depression.

metformin shown to result in increased homocysteine through depletion of folate. Metformin is also known to deplete vitamin B12 and CoQ10.  

Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.