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Nathan Goodyear

Brown adipose tissue activity after a high-calorie meal in humans - 0 views

ajcn.nutrition.org/...57.abstract

BAT brown fat high calorie diet thermogenic fat adipose tissue

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    Interesting study.  Studies have found brown fat to be thermogenic.  This study found no such association. In fact, a high calorie diet increased glucose uptake by brown fat without resultant thermogenesis.  
Nathan Goodyear

Steroid Analysis in Saliva: An overview - 0 views

www.ncbi.nlm.nih.gov/...PMC1579286

saliva salivary hormone testing hormones

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    No test is perfect. This study analyzes problems with saliva hormone testing.  The authors of this study found saliva testing optimal for cortisol and less so for sex hormones.  Other studies have contradicted this conclusion.
Nathan Goodyear

Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Nor... - 0 views

press.endocrine.org/...jc.2015-4106

low T low testosterone Testosterone free Testosterone male hormones hormones men

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    low free Testosterone, though calculated in this study, found to be associated with low T symptoms despite normal total Testosterone.  Though the "normal" total Testosterone in this study is abnormal low in other studies.  Only abstract available.
Nathan Goodyear

Testosterone treatment and risk of venous thromboembolism: population based case-contro... - 0 views

www.bmj.com/bmj.i5968

low T low Testosterone Testosterone Testosterone therapy VTE venous thromboembolism thromboembolism

shared by Nathan Goodyear on 07 Dec 16 - No Cached
  • Nathan Goodyear on 07 Dec 16
     
    Testosterone is great when needed, not doped; but Testosterone is not without risks.  Population case-control study finds increased blood clot risk in first 6 months of Testosterone therapy.  To many variables left unanswered by this study.  
Nathan Goodyear

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and ... - 0 views

www.ncbi.nlm.nih.gov/...27106765

CVD low T low testosterone estradiol Testosterone DHT dihydrotestosterone male health male hormones cardiovascular disease

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality.  Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
Nathan Goodyear

Weight Status Among Adolescents in States That Govern Competitive Food Nutrition Content - 0 views

pediatrics.aappublications.org/...437.abstract

obesity adolescents weight food nutrition

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    Scary study.  This study seems to show that state laws are the way to reduce BMI.  BMI is not a reliable measurement of Percent fat.  So, I question this study all together.  But their conclusion seems to be to attack obesity through legislation.  You should attack obesity through education.
Nathan Goodyear

EDTA Chelation Therapy: A Retrospective Study of 470 Patients - 1 views

www.drcranton.com/...study6.htm

EDTA chelation arteriosclerosis atherosclerosis CVA therapy

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    study of EDTA chelation in arteriosclerosis in retrospective study.
Nathan Goodyear

A Randomized Pilot Study of Monthly Cycled Testosterone Replacement or Continuous Testo... - 0 views

jcem.endojournals.org/...E1831.abstract

testosterone replacement study monthly cycling athletes

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    study looks at cycling Testosterone as athletes do.  The point to take from this study is that they lowered the standard Testosterone dosage by 50% and got the same results.  Traditional medicine drastically overdoses men with Testosterone.
Nathan Goodyear

The Effect of High-Intensity Intermittent Exercise on Body Composition of Overweight Yo... - 0 views

www.ncbi.nlm.nih.gov/...PMC3375095

high intensity interval training HIT HIIE exercise wieght-loss overweight obesity

shared by Nathan Goodyear on 27 Jul 12 - No Cached
  • Nathan Goodyear on 27 Jul 12
     
    another study that shows that High intensity interval training (HIT) results in fat loss.  IN this study, training consisted of 20 minutes 3 x weekly for 12 weeks.  Fat loss in total, abdominal, trunk, and visceral was decreased.  This study only looked at men.
Nathan Goodyear

Validation of salivary testosterone as a screening test for male hypogonadism - 0 views

www.cenegenicsfoundation.org/...test_for_male_hypogonadism.pdf

saliva salivary testosterone hormone hormones men male

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    This study reviewed two studies and both validated salivary testosterone as a method of testing. The statistical significance was very high. Additionally, they found a 47% decline in testosterone over the study lifespan of a man. So, again, what is the opposition to saliva testing? The only thing I can think of is resistance to change and/or lack of education. As a scientist, neither is acceptable.
Nathan Goodyear

PLoS ONE: Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease... - 0 views

www.plosone.org/...journal.pone.0030791

celiac disease PROFICEL study dysbiosis intestinal microbiota breast milk

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    fascinating article on how the environment and genetics play a role in the development of celiac disease.  In this study, the PROFICEL study, the intestinal microbiota was influenced by breast milk.  Those children breast fed had a favorable microbiota that decreased the incidence of celiac disease.
Nathan Goodyear

JAMA Network | Archives of Neurology | Damage to Lipids, Proteins, DNA, and RNA in Mild... - 0 views

archneur.jamanetwork.com/article.aspx

neurodegenerative disease free-radicals Alzheimer's disease Alzheimer's oxidative stress oxidative damage lipid peroxides isoprostanes 8-hydroxy-2-deoxyguanosine neurology

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    oxidative damage found to be present in early Alzheimer's disease.  This early mild cognitive impairment is the time for treatment to delay disease progression.  As this study points out, most studies up to this point have been done on individuals with late Alzheimer's disease.  This show that oxidative damage plays a prominent role in disease development.  This study found oxidative damage through several markers: lipid peroxides,isoprostanes, 8-hydroxy-2-deoxyguanosine...
Nathan Goodyear

Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testos... - 0 views

onlinelibrary.wiley.com/...abstract

men male testosterone estrogen estrone estradiol low T low testosterone testosterone deficiency

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Several flaws with this study. First, the majority of testing done in the meta-analysis was serum--unreliable.  Second, this study flies in the face of many other studies that have shown elevated estrogens contribute to low testosterone in men.  Third, this flies in the face of observation.  I see over and over again, by lowering a male's estrogen level, he in turn will start producing more Testosterone.  And finally, the environmental xenoestrogens have helped to contribute to a all time low of testosterone/infertility rate in men today.
Nathan Goodyear

JISSN | Full text | International Society of Sports Nutrition position stand: creatine ... - 0 views

www.jissn.com/6

creatine sports nutrition exercise

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • the energy supplied to rephosphorylate adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during and following intense exercise is largely dependent on the amount of phosphocreatine (PCr) stored in the muscle
  • Creatine is chemically known as a non-protein nitrogen
  • It is synthesized in the liver and pancreas from the amino acids arginine, glycine, and methionine
  • ...26 more annotations...
  • Approximately 95% of the body's creatine is stored in skeletal muscle
  • About two thirds of the creatine found in skeletal muscle is stored as phosphocreatine (PCr) while the remaining amount of creatine is stored as free creatine
  • The body breaks down about 1 – 2% of the creatine pool per day (about 1–2 grams/day) into creatinine in the skeletal muscle
  • The magnitude of the increase in skeletal muscle creatine content is important because studies have reported performance changes to be correlated to this increase
  • "loading" protocol. This protocol is characterized by ingesting approximately 0.3 grams/kg/day of CM for 5 – 7 days (e.g., ≃5 grams taken four times per day) and 3–5 grams/day thereafter [18,22]. Research has shown a 10–40% increase in muscle creatine and PCr stores using this protocol
  • Additional research has reported that the loading protocol may only need to be 2–3 days in length to be beneficial, particularly if the ingestion coincides with protein and/or carbohydrate
  • A few studies have reported protocols with no loading period to be sufficient for increasing muscle creatine (3 g/d for 28 days)
  • Cycling protocols involve the consumption of "loading" doses for 3–5 days every 3 to 4 weeks
  • Most of these forms of creatine have been reported to be no better than traditional CM in terms of increasing strength or performance
  • Recent studies do suggest, however, that adding β-alanine to CM may produce greater effects than CM alone
  • These investigations indicate that the combination may have greater effects on strength, lean mass, and body fat percentage; in addition to delaying neuromuscular fatigue
  • creatine phosphate has been reported to be as effective as CM at improving LBM and strength
  • Green et al. [24] reported that adding 93 g of carbohydrate to 5 g of CM increased total muscle creatine by 60%
  • Steenge et al. [23] reported that adding 47 g of carbohydrate and 50 g of protein to CM was as effective at promoting muscle retention of creatine as adding 96 g of carbohydrate.
  • It appears that combining CM with carbohydrate or carbohydrate and protein produces optimal results
  • Studies suggest that increasing skeletal muscle creatine uptake may enhance the benefits of training
  • Nearly 70% of these studies have reported a significant improvement in exercise capacity,
  • Long-term CM supplementation appears to enhance the overall quality of training, leading to 5 to 15% greater gains in strength and performance
  • Nearly all studies indicate that "proper" CM supplementation increases body mass by about 1 to 2 kg in the first week of loading
  • short-term adaptations reported from CM supplementation include increased cycling power, total work performed on the bench press and jump squat, as well as improved sport performance in sprinting, swimming, and soccer
  • Long-term adaptations when combining CM supplementation with training include increased muscle creatine and PCr content, lean body mass, strength, sprint performance, power, rate of force development, and muscle diameter
  • subjects taking CM typically gain about twice as much body mass and/or fat free mass (i.e., an extra 2 to 4 pounds of muscle mass during 4 to 12 weeks of training) than subjects taking a placebo
  • The gains in muscle mass appear to be a result of an improved ability to perform high-intensity exercise via increased PCr availability and enhanced ATP synthesis, thereby enabling an athlete to train harder
  • there is no evidence to support the notion that normal creatine intakes (< 25 g/d) in healthy adults cause renal dysfunction
  • no long-term side effects have been observed in athletes (up to 5 years),
  • One cohort of patients taking 1.5 – 3 grams/day of CM has been monitored since 1981 with no significant side effects
  • Nathan Goodyear on 27 Jan 14
     
    Nice review of the data, up to the publication date, on creatine.
Nathan Goodyear

Total Testosterone Levels and the Effect of Sildenafil on Type 2 Diabetics with Erectil... - 0 views

www.ncbi.nlm.nih.gov/...PMC3910416

low T Testosterone Diabetes sildenafil erectile dysfunction ED

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Interesting study. In this study group, 36% of type II diabetes with ED had low Testosterone.  This fits with the estimated 40% of those with Diabetes have low T. What is really interesting about this study is that the degree of improvement with ED by Sildenfafil was dependent on the Testosterone level in the low T group.  Meanining that Testosterone therapy in these men would probably be more of a therapy directed at the cause and not Sildenafil.  Of course, the Testosterone therapy would benefit glucose regulation as well documented in the literature.
Nathan Goodyear

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury... - 0 views

www.ncbi.nlm.nih.gov/...PMC1280342

ethylMercury ethyl Mercury Hg brain methylMercury Thimerosal vaccines vaccinations heavy metals toxicity

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Animal study finds that methyl Hg is not useful in determining effects of ethyl mercury.  According to this study, the conclusion is that the ethyl Mercury from Thimerosal is converted to inorganic Hg as evident in the results.  So, in essence, the ethyl mercury, considered less toxic than methyl mercury, is converted to inorganic Mercury a more toxic compound.  The results of the study revealed a higher % of inorganic Hg in the brains of those exposed to thimerosal to those exposed to methylMercury.
Nathan Goodyear

Influence of tumor necrosis factor α inhibitors on testicular function and se... - 0 views

www.fertstert.org/...abstract

TNF-alpha sperm motility low T Testosterone LH FSH autoimmune disease inflammation male men hormone hormones

shared by Nathan Goodyear on 18 Feb 14 - No Cached
  • Nathan Goodyear on 18 Feb 14
     
    Cause and effect cannot be taken from this study.  However, TNF-alpha is known to disrupt testicular function, in this case the study found decreased sperm motility, lower Testosterone levels, and increased LH and FSH at baseline.  Improvement was seen after anti-TNF-alpha therapy. The point of this study should be why the elevated TNF-alpha and attack there.
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

iospress.metapress.com/...t1717503235m8667

Testosterone alzheimer memory disease stress oxidative oxidative stress men male hormone hormones cognition

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

www.nature.com/...ncpendmet1050.html

low T Testosterone health men male hormone hormones metabolic syndrome metabolic syndrome MetS insulin resistance diabetes aging

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
  • ...18 more annotations...
  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
  • Nathan Goodyear on 03 Mar 14
     
    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

High-dose testosterone is associated with atherosc... [Maturitas. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16938416

Testosterone hormone hormones women female CVD cardiovascular health disease

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    One of the rare long-term studies of Testosterone in women.  This study was a respective study of high dose Testosterone.  The authors found an increase in atherosclerosis in the aorta versus non-HRT.
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