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Nathan Goodyear

Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS - 0 views

www.ncbi.nlm.nih.gov/...PMC3893977

PCOS polycystic ovarian syndrome LH FSH SHBG Testosterone progesterone hormones bmi

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Nathan Goodyear on 13 Sep 17
     
    study of Saudi women with PCOS finds elevated LH/FSH ratio and elevated total Testosterone levels independent of age and weight; in addition, lower FSH, SHBG, and progesterone levels we found.
Nathan Goodyear

Thieme E-Journals - Hormone and Metabolic Research / Abstract - 0 views

www.thieme-connect.com/...DOI

hormone hormones estradiol pancreatic cancer

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    small study, but males with pancreatic cancer were found to have higher levels of FSH (p < 0.01), LH and oestradiol (p < 0.001) and lower levels of progesterone (p < 0.01) and testosterone (p < 0.05) than the controls. Female patients with pancreatic cancer were found to have higher levels of oestradiol (p < 0.001) and lower levels of LH, FSH and progesterone.  Though cause and effect is not known, the expression of ER alpha in pancreatic cancer is known and the inflammatory and pro-growth signal of ER alpha is known, thus heavy stimulation would be unwise.
Nathan Goodyear

Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Ab... - 0 views

jcem.endojournals.org/...53.long

Testosterone men T E2 estradiol FSH LH HPA male hormone regulation

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    In men, Testosterone is shown to provide negative feedback on LH; but FSH is primarily regulated by estradiol.
Nathan Goodyear

Obesity-induced hypogonadism in the male: Prem... [Endocrinology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24424048

kisspeptin high fat diet diet fat LH FSH Testosterone Low T male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Nathan Goodyear on 05 Feb 14
     
    High fat diet decrease hypothalamic kisspeptin levels result in decreased GNRH release.  The result is a decrease in LH/FSH and in this case decreased Testosterone.  These were animal models.
Nathan Goodyear

Influence of tumor necrosis factor α inhibitors on testicular function and se... - 0 views

www.fertstert.org/...abstract

TNF-alpha sperm motility low T Testosterone LH FSH autoimmune disease inflammation male men hormone hormones

shared by Nathan Goodyear on 18 Feb 14 - No Cached
  • Nathan Goodyear on 18 Feb 14
     
    Cause and effect cannot be taken from this study.  However, TNF-alpha is known to disrupt testicular function, in this case the study found decreased sperm motility, lower Testosterone levels, and increased LH and FSH at baseline.  Improvement was seen after anti-TNF-alpha therapy. The point of this study should be why the elevated TNF-alpha and attack there.
Nathan Goodyear

Prevalence and impact of hyperandrogenemia in 1,21... [Endocrine. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24752393

PCOS polycystic ovarian syndrome LH androgens Testosterone glucose FSH SHBG

shared by Nathan Goodyear on 30 Apr 14 - No Cached
  • Nathan Goodyear on 30 Apr 14
     
    Not a new finding, but study finds that 60% of PCOS women have elevated androgens, male hormones.  The study also found increased LH, increased FSH, decreased SHBG, increased free androgen index, and increased fasting glucose levels.
Nathan Goodyear

Endocrine biomarkers and symptom clusters during t... [Menopause. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24781854

estrogen FSH epinephrine norepinephrine hot flashes women hormone hormones menopause cortisol Testosterone

shared by Nathan Goodyear on 07 May 14 - No Cached
  • Nathan Goodyear on 07 May 14
     
    Study finds that low estrogen, assuming estradiol, higher FSH, low epinephrine, higher norepinephrine are associated with severe hot flashes.  Of interesting note, Cortisol and Testosterone were not associated with symptom severity.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper11376.html - 0 views

endo.confex.com/...Paper11376.html

SHBG FSH free Testosterone bone men male hormone hormones low T low T low Testosterone

shared by Nathan Goodyear on 21 Jul 14 - No Cached
  • Nathan Goodyear on 21 Jul 14
     
    Higher levels of FSH and SHBG and lower levels of free Testosterone found to be associated with bone loss in older men.
Nathan Goodyear

Leptin inhibits testosterone secretion from adult rat testis in vitro. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10320818

leptin Testosterone LH FSH

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    high leptin levels found to inhibit pituitary LH/FSH release.  Of note, high leptin levels inhibited leydig cell production of Testosterone following hCG stimulation.  This is a rat in vitro study.
Nathan Goodyear

Validation of Blood Spot Sampling for Gonadotropins and Ovarian Hormone Levels in Repro... - 0 views

www.fertstert.org/...fulltext

blood spot hormone testing hormones Estradiol Progesterone LH FSH

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Nathan Goodyear on 22 Jun 15
     
    blood spot Estradiol, Progesterone, LH, and FSH levels shown to be comparable to plasma levels.
Nathan Goodyear

Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of fem... - 0 views

joe.endocrinology-journals.org/...201.abstract

bisphenol A Bisphenol-A BPA kisspeptin LH FSH Estradiol estrogen hormones female

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Mouse model finds that Bisphenol A (BPA) induces LH/FSH and Estradiol production through kisspeptin stimulation.
Nathan Goodyear

Enclomiphene citrate stimulates testosterone p... [Fertil Steril. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25044085

enclomiphen Testosterone LH FSH men male hormone hormones

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Enclomiphen, a clomid isomer, stimulates FSH and LH to preserve spermatogenesis and Testosterone production.
Nathan Goodyear

Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from... - 0 views

www.ncbi.nlm.nih.gov/...PMC4504177

vitamin d male hormones low T low Testosterone Testosterone

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • lower 25(OH)D level was significantly associated with lower total T, E2, SHBG, LH and FSH levels after adjusting for age, residence area, economic status and current smoker
  • association between 25(OH)D status and hypogonadism in Chinese men and confirms that this relationship is present in a large population
  • VDR knockout mutant mice showed gonadal insufficiencies
  • ...6 more annotations...
  • High LH and FSH levels in the male mice indicated hypergonadotropic hypogonadism
  • Another mouse study reported a tendency towards low testosterone/LH ratio and Leydig cell hyperplasia in VDR null mice
  • The serum testosterone levels could increase to normal values in vitamin D-deficient rats replete with vitamin D
  • VDR knockout mice had decreased sperm count, reduced sperm motility, and histological abnormality of the testis
  • vitamin D supplementation increases testosterone levels in non-diabetic subjects
  • The data from the European Male Ageing Study [9] indicated that 25(OH)D is positively associated with total T
  • Nathan Goodyear on 09 Jan 17
     
    Study of 713 Chinese men finds a correlation between low vitamin D and low total Testosterone.
Nathan Goodyear

Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats: Phar... - 0 views

www.tandfonline.com/...13880200903207094

Bulbine natalensis Baker stem natural hormones male hormones Testosterone natural therapies

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    Bulbine natalensis Baker stem found to increase Testosterone by up to 350% in animal studies in 2 weeks.  The dose with the optimum response was 25 and 50 mg/kg, with the most best effect at 50 mg/kg.  LH and FSH production was increase but exact mechanism not discussed.  Only abstract available here.
Nathan Goodyear

Gonadotropin therapy failure seconda... [J Clin Endocrinol Metab. 1981] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7228997

HCG anti-HCG autoimmune

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    HCG therapy induced anti-HCG antibodies.  No binding was found to TSH.  But, the concern is the binding to TSH, LH, FSH and resultant hypothyroidism or hypogonadism.
Nathan Goodyear

Annals of Internal Medicine | Long-Term Effects of Dihydrotestosterone Treatment on Pro... - 0 views

annals.org/article.aspx

DHT dihydrotestosterone prostate men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    DHT at 70 mg daily shown to have no adverse effects in the prostate of "healthy" men older than 50.  However, it did increase DHT metabolites (3 alpha androstane-diol and 3 beta androstane-diol), decreased LH, Testosterone, Estradiol, FSH, increased hemoglobin, creatinine, lean mass and decreased fat.
Nathan Goodyear

In Men, Peripheral Estradiol Levels Directly Reflect the Action of Estrogens at the Hyp... - 0 views

jcem.endojournals.org/...3324.long

low T low Testosterone low Testosterone aromatase Estradiol

shared by Nathan Goodyear on 27 Sep 13 - No Cached
  • Nathan Goodyear on 27 Sep 13
     
    peripheral aromatase activity and Testosterone to Estradiol production have central HPA axis suppression resulting in decreased LH and FSH and low Testosterone.
Nathan Goodyear

Implications of adiponectin in linking metabolism ... [Endocrine. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287788

adiponectin Testosterone hormone hormones

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Adiponectin is negatively associated with LH, FSH production at the level of the pituitary and Testosterone at the level of the testicle.  Meaning: a risking adiponectin, as found in obesity, is associated with a down regulated HPA stimulation and Testosterone production.  This study, however, found a local autocrine/paracrine effect on sperm that was quite the opposite.
Nathan Goodyear

Journal of Ovarian Research | Full text | Evaluation of the ovarian reserve function in... - 0 views

www.ovarianresearch.com/...63

Testosterone women metabolic syndrome metabolic syndrome hormone hormones

shared by Nathan Goodyear on 25 Jun 14 - No Cached
  • Nathan Goodyear on 25 Jun 14
     
    Study finds decreased ovarian reserve in women 20-29 with metabolic syndrome compared to controls.  They determined this via ovarian volume measurements as FSH, LH, Estradiol, and Progesterone did not differ.   One item of interest was that women with MetS, had significantly higher Testosterone levels compared to controls.  This association of MetS and elevated Testosterone in women has been shown consistently in the literature.  This should bring great questions to the doping of Testosterone in women today.
Nathan Goodyear

PLOS ONE: The Gut Microbiota and Developmental Programming of the Testis in Mice - 0 views

journals.plos.org/...article

hormone hormones Testosterone gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • The intra-testicular level of testosterone in GF mice was found to be significantly lower than in SPF and CBUT mice
  • This study establishes a novel role for the commensal gut microbiota in the regulation of testicular development and function
  • Absence of the normal microbiota influences the formation and the integrity of the BTB as well as the intra-testicular levels of testosterone and serum levels of LH and FSH.
  • ...8 more annotations...
  • Nutritional, socioeconomic, lifestyle and environmental factors (among others) are involved in the regulation of normal spermatogenesis.
  • he gut microbiota is one such potential source of environmental factors/products that has developed an intimate symbiotic relationship with host's physiology.
  • Manipulation of the gut microbiotia through dietary modification, pre- and probiotics can therefore be beneficial for the host's reproductive health.
  • In the current study, colonizing GF mice with CBUT resulted in an increased sperm production, suggesting that bacterial products, e.g. of fermentation, directly or indirectly, can affect the testis.
  • the absence of gut microbiota influenced testosterone levels
  • A recent study demonstrated that dietary supplementation of the probiotics Lactobacillus reuteri increased and restored testosterone levels in aging mice
  • bacterial metabolites such as butyrate have been shown to increase the levels of LH [43] and FSH
  • This suggests that butyrate most likely regulates testosterone production at the testicular level by stimulation of gene expression in Leydig cells and with little or no effect at the pituitary- hypothalamic levels.
  • Nathan Goodyear on 30 Apr 15
     
    gut micro biome effects spermatogenesis, Testosterone production, and the brain-testicle-barrier.
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