Group items tagged

testosterone replacement in men found to improve penile blood flow and thus improve erectile function.

ED in men precedes cardiovascular disease by 3-5 years.

l-Arginine with pycnogenol significantly improved ED over l-Arginine alone.

Though Testosterone plays a role, it's role in the erectile process is overblown.

low T and elevated E2 result in ED in men.  The authors conclude that E2 provides an additive effect on that of low T.  Yet, they fail to realize the previous research that high aromatase activity (Testosterone to Estradiol production) causes the low T.

nice review of the link between environment and ED in men.  No direct cause-effect, but association is definitely seen.

nice review on Arginine + citrulline in ED.  Data is limited, but studies suggest improvement with individual therapy.  

ED associated with a 3.8 x increase in Parkinson's disease.

chronic lead toxicity linked with increased ED in men.

As ED is a cardiovascular problem, it is no surprise that those with ED have an increase in CVD.

review study points out that exercise, predominantly cardio, improved ED in men.

new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!

smoking reduces serum testosterone in rats.  The real question is what does it do to the salivary levels (tissue) and the metabolism of testosterone.

ED is the result of low-grade, chronic inflammation.

This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  

Interesting study. In this study group, 36% of type II diabetes with ED had low Testosterone.  This fits with the estimated 40% of those with Diabetes have low T. What is really interesting about this study is that the degree of improvement with ED by Sildenfafil was dependent on the Testosterone level in the low T group.  Meanining that Testosterone therapy in these men would probably be more of a therapy directed at the cause and not Sildenafil.  Of course, the Testosterone therapy would benefit glucose regulation as well documented in the literature.

In rat model, Pb reduced NO and contributed to ED.  Of interest, arginine masked the effects of Pb on NO synthase and vitamin C reversed it all together.

Study links peripheral neuropathy and ED in men.  Though, both are likely a reflection of low Testosterone as elevated aromatase activity.

Another study links ED to Pb.

Environmental toxins (pesticides, solvents shown to be associated increased odds ratio for ED.