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oxidative damage found to be present in early Alzheimer's disease.  This early mild cognitive impairment is the time for treatment to delay disease progression.  As this study points out, most studies up to this point have been done on individuals with late Alzheimer's disease.  This show that oxidative damage plays a prominent role in disease development.  This study found oxidative damage through several markers: lipid peroxides,isoprostanes, 8-hydroxy-2-deoxyguanosine...

This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.

Study finds salivary 8-OHdG is associated with increased severity of ED in men.  The study found that phosphodiesterase 5 inhibitor therapy increased total and free Testosterone as well as decreased 8-OHdG.

Selenium (Se) deficiency is associated with increased oxidative stress.  Selenium is a cofactor necessary for glutathione perioxidase.  Selenium reduced 8-OHdG, promoted cell growth inhibition and cell death pointing to significant Cancer implications.

Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.