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Nathan Goodyear

LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. - Pub... - 0 views

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    metal immune reactivity plays a role in disease, particularly inflammatory disease i.e. autoimmune.  This study find benefit from MELISA assays in metal sensitivity treatment.
Nathan Goodyear

Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Gl... - 0 views

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    Study looked at the action of glutathione in plants with high metal exposure.
Nathan Goodyear

Heavy Metal-induced Immunotoxicity and Its Mechanisms | ResearchGate - 0 views

  • Heavy Metal-induced Immunotoxicity and Its Mechanisms
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    Heavy Metal-induced Immunotoxicity and Its Mechanisms
Nathan Goodyear

The long-term consequences of exposure to lead. [Isr Med Assoc J. 2009] - PubMed - NCBI - 0 views

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    Study discusses the long term consequences of chronic lead exposure.  Acute lead toxicity is not the only mechanism of lead toxicity.  Lead can be toxic in chronic exposure.  This study also touches on the aspect that serum levels on reveal recent exposure as challenge and chelation are the only way to draw out and eliminate the stored metals.  When individuals lack detoxification enzymes i.e. glutathione these metals promote more symptoms and/or disease.
Nathan Goodyear

ScienceDirect - Molecular Immunology : Mechanisms of heavy metal-induced autoimmunity - 0 views

  • Mechanisms of heavy metal-induced autoimmunity
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    Heavy metals and autoimmune disease
Nathan Goodyear

Biological and health implications of toxic heavy ... [Prog Food Nutr Sci. 1987] - PubM... - 0 views

  • hey are cumulative poison, and are toxic even at low dose
  • These metals serve no biological function and their presence in tissues reflects contact of the organism with its environment
  • heavy metals cadmium, lead, and mercury are specially prevalent in nature due to their high industrial use
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    implications of heavy metal toxicity
Nathan Goodyear

PLOS ONE: Metal and Silicate Particles Including Nanoparticles Are Present in Electroni... - 0 views

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    study finds equal parts of metal contaminants and silica in electronic cigarettes as in regular cigarettes.  One example is aluminum.  Aluminum is incredibly neurotoxic.
Nathan Goodyear

Chelation in Metal Intoxication - 0 views

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    good review in chelation of metals.
Nathan Goodyear

Patches of Disorganization in the Neocortex of Children with Autism - NEJM - 0 views

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    New study suggests that intra-uterine exposure effects prefrontal cortex development that leads to autism.  This study was conducted of postmortem samples of children with autism ranging from 2 to 15. Intra-pregnancy exposure of what?  That is the question.  Environmental toxins: whether it is all the xenoestrogens (autism at rate of 5:1 in boys), PCBs, heavy metals, and yes (lead author) preservatives, metals (Al and thermeresol) in vaccines--particularly the flu vaccine which ACOG is almost mandating during pregnancy.
Nathan Goodyear

Autoimmunity and Heavy Metals - 0 views

  • Gold may cause autoimmune thrombocytopenia, immune complex-mediated glomerulonephritis and other autoimmune disorders
  • there is solid evidence that mercury can induce autoimmune disease both in humans and experimental animals.
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    Heavy metals cause some autoimmune diseases
Nathan Goodyear

Exposure to metals. [Prim Care. 2000] - PubMed result - 0 views

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    nice review on heavy metal toxins and their effects
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

  • iron and ascorbate has long been used as an oxidizing system; the combination of these two reagents is referred to as the Udenfriend system
  • ascorbate serves as a reducing cofactor for many enzymes
  • uptake of ascorbate from the intestinal tract is very tightly controlled
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  • pharmacokinetic data indicate that intravenous administration of ascorbate can bypass this tight control resulting in highly elevated plasma levels
  • ascorbate readily oxidizes to produce H2O2, pharmacological ascorbate has been proposed as a prodrug for the delivery of H2O2 to tumors
  • Ascorbate is an excellent reducing agent and readily undergoes two consecutive, one-electron oxidations to form ascorbate radical (Asc•−) and dehydroascorbic acid (DHA)
  • Ascorbate oxidizes readily. The rate of oxidation is dependent on pH and is accelerated by catalytic metals
  • In near-neutral buffers with contaminating metals, the oxidation and subsequent loss of ascorbate can be very rapid
  • Ascorbate is required for maintaining iron in the ferrous state
  • In the presence of catalytic metal ions, ascorbate can also exert pro-oxidant effects
  • Ascorbate is an excellent one-electron reducing agent that can reduce ferric (Fe3+) to ferrous (Fe2+) iron, while being oxidized to ascorbate radical
  • In a classic Fenton reaction, Fe2+ reacts with H2O2 to generate Fe3+ and the very oxidizing hydroxyl radical
  • e presence of ascorbate can allow the recycling of Fe3+ back to Fe2+, which in turn will catalyze the formation of highly reactive oxidants from H2O2
  • Depending on concentrations, the effects of ascorbate on models of lipid peroxidation can be pro- or antioxidant
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    ferritin released enhanced pharmacologic ascorbate induced-cytotoxicity, indicating that ferritin with high iron-saturation could be a source of catalytic iron. Consistent with this, ascorbate has also been shown to be capable of releasing iron from cellular ferritin
Nathan Goodyear

Effect of aluminium metal on glutathion - PubMed Mobile - 0 views

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    Aluminum shown to decrease blood glutathione levels.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

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    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

darbre2006.pdf - 0 views

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    Heavy metals shown to be estrogenic with Cadmium being one of the biggest culprits.
Nathan Goodyear

Combined effects in toxicology--a rapid systematic testing procedure: cadmium, mercury,... - 0 views

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    heavy metals are synergistic in lower toxicity levels.
Nathan Goodyear

Vitamin C and cancer revisited - 0 views

  • It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions (5) because it does not readily autoxidize, i.e., react with oxygen (O2) to produce reactive oxygen species, such as superoxide radicals (O2•−) or H2O2
  • However, ascorbate readily donates an electron to redox-active transition metal ions, such as cupric (Cu2+) or ferric (Fe3+) ions, reducing them to cuprous (Cu+) and ferrous (Fe2+) ions, respectively
  • Reduced transition metal ions, in contrast to ascorbic acid, readily react with O2, reducing it to superoxide radicals (Reaction 2), which in turn dismutate to form H2O2 and O2
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  • The H2O2 produced this way (Reactions 1–3) seems to be key to ascorbate's antitumor effect because H2O2 causes cancer cells to undergo apoptosis, pyknosis, and necrosis
  • In contrast, normal cells are considerably less vulnerable to H2O2
  • The reason for the increased sensitivity of tumor cells to H2O2 is not clear but may be due to lower antioxidant defenses
  • In fact, a lower capacity to destroy H2O2—e.g., by catalase, peroxiredoxins, and GSH peroxidases—may cause tumor cells to grow and proliferate more rapidly than normal cells in response to low concentrations of H2O2
  • These observations, combined with the inhibitory effect on xenograft growth, provide the proof of concept that millimolar concentrations of extracellular ascorbate, achievable by i.p. injection or i.v. infusion in experimental animals and humans, respectively, exert pro-oxidant, antitumor effects in vivo.
  • They also show that the concentration of the ascorbyl radical correlates with the concentration of H2O2 in interstitial fluid, whereas no H2O2 can be detected in blood or plasma
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    review of the mechanism of how extracellular AA, only obtainable from parenteral dosing, can produce H2O2 extracellularly to then be cytotoxic to cancer cells.
Nathan Goodyear

https://dl-web.dropbox.com/get/Public/Research/ane_7212-1.pdf?w=AABZMjLPg8k92S9AxmjD0IN... - 0 views

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    Good non biased look at heavy metals, particularly Hg, and autism.  The authors of this study found the same neurologic pathology biochemically in Hg poisoning as in autism.  
Phiten Singapore

Benefits of Phiten AquaMetal Technology - 0 views

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    AquaTitanium, Phiten's most commonly utilized AQUA-METAL, is used as a dye-like material and permeated into the fibers of Phiten fabric products becoming a component of the finished product.
wheelchairindia9

R O M Knee Brace - 0 views

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    PF Night Splint Compared to plantar based splints, patients prefer dorsal models because they are less bulky, cooler, lower profile and easier to walk in at night. PF Night Splint includes all of these features and more. Neoprene calf and toe straps along with gel padding on the top of the foot help reduce pressure points and the plastic-free bottom offers safer nighttime ambulation. Even added more room in the forefoot to accommodate wider feet and new flexible shell allows easier nighttime ambulation without compromising the ability to hold the foot at 90° during rest. Finally, a plantar fasciitis splint patients will wear all night! Neoprene calf. Padded foam liner. Fits right or left. Not made with natural rubber latex. PF Night Splint (Derotation) Applications Prevention and correction of foot drop. Night splint for early healing. Ambulatory, can be used as a day splint. Perfect post-operative immobilisation and derotation. Peroneal / Peritibial nerve or muscle damage. Ankle or Plantar flexion contracture and functional alignment. Can be used to protect the diabetic/ injured ankle & foot. PF Night Splint (Derotation) Features Removable de-rotation bar. Moulded foot casing, aesthetically pleasing and durable. Effective Liner, improved comfort. Highly functional Design, customized degree of dorsiflexion. Double strapping mechanism, better grip. Tynor R O M Knee Brace Prefabricated, custom adjusted R.O.M. Knee Brace controls and restrict flexion/extension of the knee joint through a multi-point joint fixation system to allow a range of motion or immobilization to the knee. Universal design allows it to be used on quite a big range of population and for a multiple orthopedic problems associated with knee joint. Immobilization at any angle Controlled motion between any two angles Quick and easy application and removal. Tynor R O M Knee Brace Features R.O.M. Dial 0 to 120 degree flexion. 0 to 60 degree hyper extention Locking at any
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