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Nathan Goodyear

HOMOCYSTEINE AND CARDIOVASCULAR DISEASE - Annual Review of Medicine, 49(1):31 - 0 views

www.annualreviews.org/...annurev.med.49.1.31

HOMOCYSTEINE cardiovascular disease CAD thromboembolism DVT artherosclerosis

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine increases risk for artherosclerosis, cardiovascular disease, and thromboembolism
Nathan Goodyear

Risk of Venous Thromboembolism in Men Receiving Testosterone Therapy - Mayo Clinic Proc... - 0 views

www.mayoclinicproceedings.org/...fulltext

testosterone therapy testosterone replacement therapy DVT PE VTE venous thromboembolism testosterone

shared by Nathan Goodyear on 30 Jul 17 - No Cached
  • Nathan Goodyear on 30 Jul 17
     
    Venous thromboembolism found not be associated with prior Testosterone therapy in men.
Nathan Goodyear

Testosterone treatment and risk of venous thromboembolism: population based case-contro... - 0 views

www.bmj.com/bmj.i5968

low T low Testosterone Testosterone Testosterone therapy VTE venous thromboembolism thromboembolism

shared by Nathan Goodyear on 07 Dec 16 - No Cached
  • Nathan Goodyear on 07 Dec 16
     
    Testosterone is great when needed, not doped; but Testosterone is not without risks.  Population case-control study finds increased blood clot risk in first 6 months of Testosterone therapy.  To many variables left unanswered by this study.  
Nathan Goodyear

Diabetes Care - 0 views

care.diabetesjournals.org/...dc16-1534

diabetes contraception thromboembolism blood clothes

shared by Nathan Goodyear on 13 Mar 17 - No Cached
  • Nathan Goodyear on 13 Mar 17
     
    contraceptive patch and progestin injectable contraception associated with highest risk of thromboembolism in women with diabetes.
Nathan Goodyear

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results F... - 0 views

atvb.ahajournals.org/...340

biodentical hormone therapy postmenopausal stroke

shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk.
  • Oral but not transdermal estrogens were associated with an increased thrombotic risk
  • There was no significant association of venous thromboembolism with progesterone
  • Nathan Goodyear on 30 Mar 11
     
    bioidentical hormones do not increase stroke risk; also, route of delivery impacts stroke risk
Nathan Goodyear

Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and... - 0 views

atvb.ahajournals.org/...3071.short

transdermal bioidentical estrogen progesterone estradiol thromboembolism DVT

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estrogen/progesterone therapy does not increase thrombotic risk
Nathan Goodyear

Differential Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Sensitiv... - 0 views

atvb.ahajournals.org/...1671.short

oral estradiol estrogen transdermal bioidentical DVT thromboembolism

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase blood clot risk, when compared with oral estradiol
Nathan Goodyear

ScienceDirect - Maturitas : Transdermal estradiol does not impair hemostatic biomarkers... - 0 views

www.sciencedirect.com/...S0378512204001173

DVT thromboembolism transdermal estradiol bioidentical hormones

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase thrombotic risk
Nathan Goodyear

Anemia in cancer - 0 views

annonc.oxfordjournals.org/...vii167.long

cancer anemia

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is a frequent finding in cancer patients, occurring in >40% of cases
  • chemotherapy, the incidence of anemia may rise to 90%
  • Anemia exerts a negative influence on the quality of life
  • ...17 more annotations...
  • Anemia has also been identified as an adverse prognostic factor
  • mild (10 g/dl—normal), moderate (8–10 g/dl), severe (6.5–8 g/dl) and life threatening (<6.5 g/dl or unstable patient) anemia
  • anemia in cancer patients is often multifactorial.
  • Cancer itself can directly cause or exacerbate anemia either by suppressing hematopoiesis through bone marrow infiltration or production of cytokines that lead to iron sequestration, or by reduced red blood cell production
  • in inflammatory anemia, iron deficiency should be defined by a low transferrin saturation of <20%, ferritin levels of <100 ng/ml and a low reticulocyte hemoglobin concentration of <32 pg
  • anemia to thrombocytosis, as commonly seen in cancer patients
  • TNF-α inhibits hemoglobin production
  • treatment itself may be a major cause of anemia
  • Other cytokines, such as interleukin-6 (IL-6), IL-1 and interferon-γ, have also been shown to inhibit erythroid precursors in vitro [9], albeit to a lesser extent
  • In inflammation, from whatever cause, IL-6 induces the liver to produce hepcidin. Hepcidin decreases iron absorption from the bowel and blocks iron utilization in the bone marrow
  • Numerous in vitro studies have illustrated the central role of TNF-α in the pathogenesis of anemia
  • nephrotoxic effects of particular cytotoxic agents such as platinum salts can also lead to the persistence of anemia through reduced Epo production by the kidney
  • Currently two options are at the disposal of the clinician for the treatment of anemia in cancer patients: transfusion of packed red blood cells and the use of erythropoiesis-stimulating agents (ESAs)
  • The goal of the treatment is to relieve the symptoms of anemia such as fatigue and dyspnea.
  • Transfusion of 1 unit of packed red blood cells has been estimated to result in an increase in the hemoglobin level of 1 g/dl in a normal-sized adult
  • a higher mortality rate in patients receiving ESA treatment
  • Recent concerns regarding the risk of thromboembolism in patients treated with ESA have been corroborated by the meta-analyses conducted by Tonnelli and Bennett
  • Nathan Goodyear on 30 Mar 15
     
    Great review of anemia in Cancer:  1)  blood loss 2)  increased RBC loss 3)   decreased RBC production Cancer infiltration of marrow can reduce hematopoiesis.  Inflammatory cytokines can reduce hematopoiesis.  Inflammatory cytokines can block Fe absorption.  Chemo and radiation can cause anemia--particularily platinum based therapies.
Nathan Goodyear

High D-dimer levels are associated with poor prognosis in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC3409812

cancer D-dimer

shared by Nathan Goodyear on 10 Jul 18 - No Cached
  • a systemic activation of blood coagulation and procoagulant changes in the hemostatic system have frequently been observed in cancer patients, even in the absence of venous thromboembolism
  • Thrombin is a pivotal enzyme in the process of blood coagulation and leads to the conversion of fibrinogen to fibrin, which is the end product of blood coagulation and finally results in the formation of a fibrin clot
  • deposition of fibrin, which has an important role in the formation of tumor stroma and hematogenous spread of tumor cells.
  • ...5 more annotations...
  • The interaction of fibrin, platelets and tumor cells leads to the formation of platelet-fibrin-tumor-cell aggregates that promote endothelial adhesion and metastatic spread, as well as tumor cell growth and tumor cell survival
  • fibrin degradation products have been shown to display strong angiogenic properties
  • D-dimer is a biomarker that globally indicates the activation of hemostasis and fibrinolysis
  • It is a degradation product of fibrin
  • high D-dimer levels were reported to be predictive of the occurrence of VTE in cancer patients
  • Nathan Goodyear on 10 Jul 18
     
    elevated D-Dimer associated with poor prognosis in cancer. Good review of cancer and ehmostasis.
Nathan Goodyear

Four Thrombotic Events Over 5 Years, Two Pulmonary Emboli and Two Deep Venous Thrombosi... - 0 views

journals.sagepub.com/...2324709616661833

VTE Testosterone venous thromboembolism testosterone therapy testosterone replacement therapy

shared by Nathan Goodyear on 30 Jul 17 - No Cached
  • Nathan Goodyear on 30 Jul 17
     
    VTE in man as a result of supra-physiologic Testosterone and high aromatase activity prior to and on anticoagulant therapy.
Nathan Goodyear

http://www.jpagonline.org/article/S1083-3188(15)00211-9/pdf - 0 views

www.jpagonline.org/...pdf

VTE contraception venous thromboembolism clotting

shared by Nathan Goodyear on 08 Sep 17 - No Cached
  • Nathan Goodyear on 08 Sep 17
     
    review of VTE risk in adolescent women on hormonal contraception.  Good review of the clotting cascade as well.  
Nathan Goodyear

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical... - 0 views

ascopubs.org/...JCO.19.01461

DVT pulmonary embolus deep venous thrombosis PE pulmonary emboli anti-coagulant cancer

shared by Nathan Goodyear on 04 Jul 21 - No Cached
  • Nathan Goodyear on 04 Jul 21
     
    Updated recommendations
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