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High dose vitamin E, in doses up to 2,000 IU, in patients with Parkinson, Alzheimers and tar dive dyskinesia found to be safe and somewhat effective in these disease states in older individuals.  The length of the studies reviewed were up to 2 years.

excellent article on the imaging of excitotoxicity.  Glutamate excitotoxicity is a key component in neurodegenerative diseases: Alzheimers, Parkinsons, ALS, MS...

Inflammation plays an important role in Alzheimers disease.  Likewise, the ability to resolve inflammation is altered, as this study shows.  This points to natural therapies i.e. omega-3, curcumin, vitamin D...

Alzheimer's model finds that amyloid-beta supresses vitamin D receptor.  This study found that vitamin D therapy protected neurons by up regulating vitamin D receptors.  This prevented cytotoxicity and cell death.

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

microglial and inflammatory response in Alzheimer's disease.  Agonists of PPAR-gamma inhibit this action.  This has important implications in reducing the local inflammatory response found in the brains of those with Alzheimers and other neuordegenerative disease.

neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas.  Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults.  This is the same process found in Alzheimers and other excitotoxicity disease states.  Addtionally, it is also involved in most chronic diseases of aging.

elevated homocysteine and low folic acid levels associated with increased risk of Alzheimer's disease and dementia.

vitamin C inhibits acetylcholinesterase.  This will increase acetylcholine and thus can play a role in Alzheimer's disease.  People with Alzheimers disease have low levels of Vitamin C.  Vitamin C shown to improve memory in Alzheimer's mouse model.

alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.

Alpha lipoic acid at relatively low oral dosing found to slow progression of moderate dementia as compared to cholinesterase inhibitors.

pre-diabetes increases risk of neurodegenerative diseases ie. dementia, Alzheimers...

CoQ10 may be used to slow progression of neurodegenerative diseases such as Alzheimers, Parkinson's, ALS...

Mitochondrial dysfunction at heart of diseases such as Parkinson's, Alzheimers, MS, ALS..

good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction

Grape seed extract and curcumin shown to reduce amyloid plaques and reduce inflammation in the brain: promising treatment in Alzheimers disease

Coconut oil found to "rescue" neurons in vitro exposed to amyloid Beta.  It was also found to reduce/protect against mitochondrial damage from amyloid-beta.

Alzheimer's is a mental illness that mostly affects the elderly. It is characterized by dementia, cognitive impairment, and mood swings. The patient gradually fades into a state of perpetual darkness and lack of self-awareness. Here are some steps we can take to reduce our own risk.

Scientists are trying to find ways to prevent Alzheimer's before it comes knocking at your doorstep. Extensive research is taking place even as you read this. Everyone hopes to put together the answer before it becomes a global issue. Here are a few risk factors that you can and can't avoid:

Great review on APOE and its contribution to Alzheimer's disease risk.

Huperzine A at doses up to 400 mcg shown to benefit people with Alzheimer's disease, with no significant side effects.