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Nathan Goodyear

Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose ... - 0 views

ajpregu.physiology.org/...R950

fructose metabolic dysfunction

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    fructose increases sympathetic tone.  This has important implications in metabolic syndrome and cardiovascular disease.
Nathan Goodyear

The benefits and risks of testosterone replacement therapy: a review - 0 views

www.ncbi.nlm.nih.gov/...PMC2701485

hypogonadism Low T Testosterone male hormone hormones men therapy

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    Benefits and risks of testosterone therapy discussed.  This study gives a brief history of hypogonadism,  highlights the different therapeutic techniques.  Most important, is the evidence based positive effects and side effects. The majority of the side effects occurs through overdosing and the physiologic dysfunction that occurs in these men's micronenvironments.
Nathan Goodyear

Testosterone Concentrations in Women Aged 25-50 Years: Associations with Lifestyle, Bod... - 0 views

aje.oxfordjournals.org/...256.full

women testosterone inflammation hormone hormones disease obesity overweight smoking

shared by Nathan Goodyear on 26 Sep 13 - No Cached
  • Increasing weight was associated with increasing total testosterone concentration at every examination
  • Measures of body composition were consistently associated with testosterone concentrations in a dose-response relation
  • Increased percent body fat, assessed with DEXA, was associated with higher levels of testosterone
  • Nathan Goodyear on 26 Sep 13
     
    Elevated Testosterone in some women create major metabolic dysfunction.
Nathan Goodyear

Uric acid induces hepatic steatosis by generatio... [J Biol Chem. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23035112

uric acid mitochondria non-alcoholic fatty liver fructose triglyceride oxidative stress fatty liver liver ATP

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Elevated uric acid levels up regulate fructose metabolism to triglycerides and fatty liver.  This study finds that liver mitochondrial oxidative stress is also evident.  This mitochondrial dysfunction also leads to compromised ATP production and fat accumulation specifically through inhibition of aconitase..
Nathan Goodyear

Diverse Influences of Androgen-Disrupting Chemi... [Inflammation. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287822

Bisphenol-A bisphenol A BPA EDC endocrine disrupting chemicals NO inflammation

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Study proposed immune dysfunction as a result of EDC like BPA. Bisphenol A induced cell apoptosis as well as a reduction of nitric oxide.
Nathan Goodyear

A randomised interventional trial of omega-3-p... [Ann Rheum Dis. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17875549

Lupus omega-3 n-3 fish oil fish oil oxidative stress endothelial function

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Omega-3 supplementation beneficial in patients with Lupus.  This study found a reduction in oxidative stress and endothelial dysfunction
Nathan Goodyear

Equine Estrogens Impair Nitric Oxide Production and Endothelial Nitric Oxide ... - 0 views

hyper.ahajournals.org/...405.long

premarin estradiol HRT BHRT eNOS NO nitric oxide endothelium

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    This is the perfect study to compare synthetic, unnatural hormones with bioidentical hormones.  Premarin was compared with bioidentical estradiol.  Premarin reduced the endothelial NO synthase transcription and activity by 30-50% compared to Estradiol.   Thus, premarin results in a lower NO production and thus greater endothelial dysfunction compared to Estradiol.
Nathan Goodyear

Vascular Aging in Women: is Estrogen the Fountain of Youth? - 0 views

www.ncbi.nlm.nih.gov/...PMC3368545

estrogen therapy hormon hormones post-menopausal NO vascular women

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    Estrogen improves vascular function in postmenopausal women.  The mechanism of action is through the increased nitric oxide production with estrogen therapy.  This increase in nitric oxide reduces endothelial dysfunction.
Nathan Goodyear

Long-term persistence of vaccine-derived alu... [J Inorg Biochem. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19748679

aluminum vaccine vaccinations neurologic brain cognition

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Migration and long-term neurologic dysfunction as a result of aluminum hydroxide.
Nathan Goodyear

Mercury intolerance in relation to superoxide di... [Environ Res. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10856185

mercury Hg SOD superoxide disumutase

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    mercury causes SOD dysfunction.
Nathan Goodyear

Dietary intervention impact on gut microbial gene ric... [Nature. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23985875

gut GI microbiota bacteria dysbiosis

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Gut bacteria diversity associated with metabolic dysfunction, low-grade inflammation and obesity
Nathan Goodyear

Testosterone Supplementation and Sexual Function: ... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24697970

low T Testosterone male hypogonadism hormone hormones libido bias men

shared by Nathan Goodyear on 06 Apr 14 - No Cached
  • Nathan Goodyear on 06 Apr 14
     
    Meta-analysis finds bias in industry studies versus independent studies.  No surprise there.   Testosterone in this meta-analysis was found to aid sexual dysfunction in men with hypogonadism.
Nathan Goodyear

http://www.scielo.br/pdf/bjmbr/v44n9/1088.pdf - 0 views

www.scielo.br/...1088.pdf

mercury Hg Pb gadolinium cardiovascular system oxidative stress hypertension disease heavy metals

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Nice review on the mechanism of Hg, Pb and gadolinium on the vascular system.  Oxidative stress is increased.  ACE is increased.  Increased vascular reactivity occurs.  Cardiovascular dysfunction results.
Nathan Goodyear

JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC3835653

JNK inflammation obesity insulin resistance insulin resistance

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    JNK pathway plays important role in inflammation signaling.  In this article, JNK activation plays role in insulin resistance, obesity, and metabolic dysfunction.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Vall... - 0 views

onlinelibrary.wiley.com/...64A32FF54A326602F0ECF9E.f02t04

ED erectile dysfunction men peripheral neuropathy

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Study links peripheral neuropathy and ED in men.  Though, both are likely a reflection of low Testosterone as elevated aromatase activity.
Nathan Goodyear

Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements - 0 views

joe.endocrinology-journals.org/...347.full

adipose adipose tissue metabolic syndrome Testosterone

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Animal study of metabolic syndrome finds that Testosterone improves metabolic dysfunction in visceral adipose tissue.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15721881

Pb lead SOD CAT GPX detoxification superoxide disumutase catalase glutathione glutathione peroxidase

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb induces dysfunction of SOD, CAT, and GPX.
Nathan Goodyear

Erectile dysfunction and depression in patients with chronic lead poisoning - Gonulalan... - 0 views

onlinelibrary.wiley.com/...abstract

Pb lead erectile dysfunction

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Another study links ED to Pb.
Nathan Goodyear

Environmental Agents and Erectile Dysfunction: A Study in a Consulting Population - OLI... - 0 views

onlinelibrary.wiley.com/...abstract

ED erectile dysfunction environmental toxins environment pesticides solvents

shared by Nathan Goodyear on 17 Sep 14 - No Cached
  • Nathan Goodyear on 17 Sep 14
     
    Environmental toxins (pesticides, solvents shown to be associated increased odds ratio for ED.
Nathan Goodyear

Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at t... - 0 views

www.sciencedirect.com/...S2212877813000598

metabolic endotoxemia obesity

shared by Nathan Goodyear on 19 Sep 14 - No Cached
  • Nathan Goodyear on 19 Sep 14
     
    metabolic endotoxemia leads to metabolic dysfunction and metabolic syndrome.
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