Fantastic review of oxidative damage and the CNS. This is a 2006 review of our understanding of how neurodegeneration occurs through oxidative stress and of course poor detoxification.
children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione
This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism
increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
Worldwide, the rate of autism has been steadily rising.
Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism
There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.
Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.
Black Spanish radish found to up regulate phase I/II liver detoxification with tylenol exposure. Now, this was sponsored by a maker of a herbal product so that would include some potential bias.
Red wine to increase testosterone levels? According to this study, yes. How? By interfering with the elimination through the UGT2B17 detoxification pathway.
Downside of this study is that this is in vitro and not in vivo.
Glyphosate, component of Roundup is well known to be an endocrine disruptor. This rat study describes the mechanism of disruption of the Sertoli cells resulting in male infertility. In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification. If that is not enough, oxidative damage marker TBARS was elevated.
SAMe found to be low in those with Crohn's and Ulcerative colitis disease. Is IBD a methylation disease? Is IBD a detoxification deficiency state due to lack of methylation?