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Nathan Goodyear

The Detoxification Enzyme Systems - 0 views

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    Great review of phase I and II detoxification pathways and mechanisms.
Nathan Goodyear

ScienceDirect - Clinica Chimica Acta : Analysis of glutathione: implication in redox an... - 0 views

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    nice review of glutathione, poor detoxification, and disease
Nathan Goodyear

The detoxification enzyme systems. [Altern Med Rev. 1998] - PubMed - NCBI - 0 views

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    great read on detoxification.  There is a pdf available at http://www.adltests.com/assets/files/pdf/Liver_Detoxification_Review_Liska.pdf
Nathan Goodyear

Oxidative stress and neurodegeneration: where are we now? - Halliwell - 2006 - Journal ... - 0 views

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    Fantastic review of oxidative damage and the CNS.  This is a 2006 review of our understanding of how neurodegeneration occurs through oxidative stress and of course poor detoxification.
Nathan Goodyear

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in... - 0 views

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    in this study, children with autism found to have detoxification impairment.  Particularily here, methylation disruption and glutathione depletion.
Nathan Goodyear

http://www.nutri-online1.co.uk/LinkClick.aspx?fileticket=t2zR1kIHuCA%3D&tabid=101&mid=1260 - 0 views

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    Detoxification and chronic disease.
Nathan Goodyear

Oxidative Stress in Autism - 0 views

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    high oxidative stress in autism will compromise detoxification. OR is it the other way around? Low Selenium is commonly found in those with autism.
Nathan Goodyear

Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase ... - 0 views

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    Mercury and changes in detoxification biomarkers.
Nathan Goodyear

Biometabolic Analysis (January 2011) Townsend Letter for Doctors & Patients - 0 views

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    nice brief discussion of detoxification
Nathan Goodyear

Metabolic polymorphisms. [Pharmacol Ther. 1993 Feb-Mar] - PubMed result - 0 views

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    decrease detoxification increases risk of cancer
Nathan Goodyear

ScienceDirect - Clinical Immunology : Oral sulforaphane increases Phase II antioxidant ... - 0 views

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    sulphoraphane increases Phase II detoxification
Nathan Goodyear

Oxidative stress in Alzheimer's disease. [Pathophysiology. 2006] - PubMed result - 0 views

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    Glutathione is most important in detoxification of environmental toxins
Nathan Goodyear

Metabolic biomarkers of increased oxidative stress... [Am J Clin Nutr. 2004] - PubMed r... - 0 views

  • children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione
  • This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism
  • increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
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    detoxification impairment and the markers to assess it in children with ASD
Nathan Goodyear

Understanding and determining the etiology of auti... [Cell Mol Neurobiol. 2010] - PubM... - 0 views

  • Worldwide, the rate of autism has been steadily rising.
  • Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism
  • There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.
  • ...1 more annotation...
  • Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
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    Autism has many potential causes.  At the heart is poor detoxification
Nathan Goodyear

Hormones.gr - Plasma Interleukin-6 levels, glutathione peroxidase and isoprostane in ob... - 0 views

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    Detoxification with glutathione reduces oxidative stress and thus weight.
Nathan Goodyear

ScienceDirect - Obstetrics & Gynecology : Low whole blood glutathione levels in pregnan... - 0 views

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    glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.
Nathan Goodyear

BMC Complementary and Alternative Medicine | Full text | An open label pilot study to e... - 0 views

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    Black Spanish radish found to up regulate phase I/II liver detoxification with tylenol exposure.  Now, this was sponsored by a maker of a herbal product so that would include some potential bias.
Nathan Goodyear

Nutrition Journal | Full text | Red wine and components flavonoids inhibit UGT2B17 in v... - 0 views

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    Red wine to increase testosterone levels?  According to this study, yes.  How?  By interfering with the elimination through the UGT2B17 detoxification pathway.   Downside of this study is that this is in vitro and not in vivo.
Nathan Goodyear

Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

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    Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  
Nathan Goodyear

Low S-adenosylmethionine concentrations fo... [Clin Chem Lab Med. 2004] - PubMed - NCBI - 0 views

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    SAMe found to be low in those with Crohn's and Ulcerative colitis disease.  Is IBD a methylation disease?  Is IBD a detoxification deficiency state due to lack of methylation?
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