Group items tagged CAT - Dr. Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15721881

Pb lead SOD CAT GPX detoxification superoxide disumutase catalase glutathione glutathione peroxidase

shared by Nathan Goodyear on 16 Sep 14 - No Cached

Nathan Goodyear on 16 Sep 14

Pb induces dysfunction of SOD, CAT, and GPX.

<div class="cArrow"> </div><div class="cContentInner">Pb induces dysfunction of SOD, CAT, and GPX.</div>

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Implications of free radicals and antioxidant levels in carcinoma of the breast: A neve... - 0 views

www.indianjcancer.com/article.asp

SOD superoxide disumutase catalase antioxidants antioxidant breast cancer cancer malondialdehyde MDA lipid peroxides oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached

Experimental investigations as well as clinical and epidemiological findings have provided evidence supporting the role of reactive oxygen metabolites or free radicals such as singlet oxygen O 2 - , superoxide anions (O 2 ), hydrogen peroxide (H2 O2 ) and hydroxyl radical in the etiology of cancer.
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Certain aldehydes such as Malonyldialdehyde (MDA), the end product of lipid peroxidation arising from free radical degeneration of polyunsaturated fatty acids can cause cross linking in lipids, proteins and nucleic acids leading to cellular damage.
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In this study, patients with cancer exhibited higher levels of MDA, both in tissues and serum (p<0.001) compared to the control group [Table 1]. In tissue, the MDA level in stage IV was significantly higher as compared to stage I indicating increased free radical activity with increasing severity of cancer
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From these observations, it can be concluded that MDA levels play an important role in assessing the outcome of cancer
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SOD and CAT are considered primary antioxidant enzymes, since they are involved in direct elimination of reactive oxygen metabolites. [13-16] They also act as anti-carcinogens and inhibitors at initiation and promotion/transformation stage in carcinogenesis
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In our study, SOD and CAT levels were found to be low in all cancer patients as compared to controls
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Fridovich and Tayarani have demonstrated in their respective studies that the reduction in SOD activity increases the toxic effects of O2 - and this might lead to severe cellular damage.
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Mehrotra et al. in their study also observed high levels of MDA and low levels of SOD and CAT in patients of cancer cervix which is in sync with our observations.
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strong evidence regarding the definitive role of free radicals in breast malignancy.
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Nathan Goodyear on 10 Nov 14

This study finds a strong correlation between advancing breast cancer, decreased catalase and SOD with increasing MDA. The authors of this study conclude this is a key factor in carcinogenesis and not a by-product of cancer. This flies in the face of traditional medicines fear of antioxidant therapy in cancer.

<div class="cArrow"> </div><div class="cContentInner">This study finds a strong correlation between advancing breast cancer, decreased catalase and SOD with increasing MDA. The authors of this study conclude this is a key factor in carcinogenesis and not a by-product of cancer. This flies in the face of traditional medicines fear of antioxidant therapy in cancer.</div>

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Her Story of "A for Cat" - 0 views

Sn films #shortfilm funnyVideo comedyvideo anotherBusyDay kidsLife

shared by snfilms on 19 Aug 20 - No Cached

snfilms on 19 Aug 20

"A for Cat"

<div class="cArrow"> </div><div class="cContentInner">"A for Cat" </div>

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Oxidative response gene polymorphisms and risk of adult brain tumors - 0 views

www.ncbi.nlm.nih.gov/...PMC2666247

brain tumor tumors CNS oxidative damage meningioma glioma

shared by Nathan Goodyear on 04 Mar 13 - No Cached

Nathan Goodyear on 04 Mar 13

Good study shows that genetic polymorphisms play role in brain tumor risk with oxidative damage. This study found an increased risk with SOD 2/3, and with CAT polymorphisms.

<div class="cArrow"> </div><div class="cContentInner">Good study shows that genetic polymorphisms play role in brain tumor risk with oxidative damage. This study found an increased risk with SOD 2/3, and with CAT polymorphisms. </div>

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Polysaccharides from Cordyceps sinensis mycelium ... [Pharm Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24047103

Cordyceps Cordyceps sinensis exercise performance oxidative stress

shared by Nathan Goodyear on 27 Jan 14 - No Cached

Nathan Goodyear on 27 Jan 14

Mouse model finds that Cordyceps increased the interval to exhaustive exercise induced oxidative stress. SOD, Cat, and GPx were increased in the low, intermediate, and high dose Cordyceps groups. Oxidative stress markers MDA and 8-OHdG were lower in all groups

<div class="cArrow"> </div><div class="cContentInner">Mouse model finds that Cordyceps increased the interval to exhaustive exercise induced oxidative stress. SOD, Cat, and GPx were increased in the low, intermediate, and high dose Cordyceps groups. Oxidative stress markers MDA and 8-OHdG were lower in all groups</div>

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Physical activity and cancer prevention-data from epidemiologic studies - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=15274899

exercise cancer cancer prevention colon cancer breast cancer

shared by Nathan Goodyear on 13 Jan 13 - No Cached

Nathan Goodyear on 13 Jan 13

regular exercise reduces breast and colon cancer risk by 30-40%.

<div class="cArrow"> </div><div class="cContentInner">regular exercise reduces breast and colon cancer risk by 30-40%.</div>

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Salivary cortisol as an alternative for serum cortisol in the low-dose adrenocorticotro... - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=22599634

saliva salivary cortisol estrogen hormone hormones test testing evaluation

shared by Nathan Goodyear on 29 Nov 11 - No Cached

Nathan Goodyear on 29 Nov 11

salivary cortisol superior to serum cortisol in women on estrogen therapy.

<div class="cArrow"> </div><div class="cContentInner">salivary cortisol superior to serum cortisol in women on estrogen therapy.</div>

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Testosterone improves rehabilitation outcomes in ill older men - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=1428723

Testosterone rehabilitation men hormone hormones

shared by Nathan Goodyear on 10 Dec 13 - No Cached

Nathan Goodyear on 10 Dec 13

Testosterone improved rehab in older men

<div class="cArrow"> </div><div class="cContentInner">Testosterone improved rehab in older men</div>

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Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 ... - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=3369697

Vitamin B6 brain

shared by Nathan Goodyear on 20 Apr 11 - No Cached

Nathan Goodyear on 20 Apr 11

Vitamin B6 very important in brain physiologic function

<div class="cArrow"> </div><div class="cContentInner">Vitamin B6 very important in brain physiologic function</div>

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Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium... - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=14869409

antioxidants toxic metals arsenic cadmium

shared by Nathan Goodyear on 19 Apr 11 - No Cached

Nathan Goodyear on 19 Apr 11

antioxidants aid in cadmium and arsenic chelation

<div class="cArrow"> </div><div class="cContentInner">antioxidants aid in cadmium and arsenic chelation</div>

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ScienceDirect - Food and Chemical Toxicology : Neuroprotective effect of ginger on anti... - 0 views

www.sciencedirect.com/science

Ginger diabetes oxidative stress

shared by Nathan Goodyear on 27 Apr 11 - No Cached

A marked decrease in anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and increase in malondialdehyde (MDA) was observed in the diabetic rats
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inger may be used as therapeutic agent in preventing complications in diabetic patients.
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These results suggest that ginger exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating the MDA levels to the normal levels in the diabetic rats
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Nathan Goodyear on 27 Apr 11

Ginger reduces oxidative stress in diabetic rat model

<div class="cArrow"> </div><div class="cContentInner">Ginger reduces oxidative stress in diabetic rat model</div>

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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation - ScienceDi... - 0 views

www.sciencedirect.com/...S1934590919302759

cancer radiation cat scan imaging CT

shared by Nathan Goodyear on 19 Jul 19 - No Cached

Nathan Goodyear on 19 Jul 19

Low dose radiation from CT found to contribute to altered genetic expression of p53 tumor suppressor gene to give competitive advantage to potential cancer cells over health cells.

<div class="cArrow"> </div><div class="cContentInner">Low dose radiation from CT found to contribute to altered genetic expression of p53 tumor suppressor gene to give competitive advantage to potential cancer cells over health cells.</div>

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