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Nathan Goodyear

Endocrine Disruptors: From Endocrine to Metabolic Disruption - 0 views

www.bionut.ki.se/...Desvergne.pdf

endocrine disruptors EDC hormone hormones xenoestrogens

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Endocrine disruption starts early due to EDC and effects last life long.
Nathan Goodyear

Human biological monitoring of suspected endocrine-disrupting compounds Fanib... - 0 views

www.ajandrology.com/article.asp

Xenoestrogens EDC endocrine disrupting chemicals male hormones

shared by Nathan Goodyear on 24 Feb 14 - No Cached
  • Nathan Goodyear on 24 Feb 14
     
    Review of xenoestrogens and techniques for evaluation.  Brief discussion of the different EDCs is included, but the majority of the study is to evaluate the different testing techniques.
Nathan Goodyear

Diverse Influences of Androgen-Disrupting Chemi... [Inflammation. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287822

Bisphenol-A bisphenol A BPA EDC endocrine disrupting chemicals NO inflammation

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Study proposed immune dysfunction as a result of EDC like BPA. Bisphenol A induced cell apoptosis as well as a reduction of nitric oxide.
Nathan Goodyear

Maternal Cypermethrin Exposure during the Perinatal... [PLoS One. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24810582

EDC endocrine disrupting chemicals xenoestrogens male hormone hormones men Testosterone pregnancy perinatal exposure

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Nathan Goodyear on 12 May 14
     
    another study points to the negative development effects of EDCs.  In this animal study, Cypermethrin exposure in the Perinatal period, disrupts testes development which resulted in decreased Testosterone production in adults.
Nathan Goodyear

http://apps.who.int/iris/bitstream/10665/78102/1/WHO_HSE_PHE_IHE_2013.1_eng.pdf - 0 views

apps.who.int/...WHO_HSE_PHE_IHE_2013.1_eng.pdf

EDC endocrine disrupting chemicals endocrine disruptors hormones

shared by Nathan Goodyear on 21 Jul 14 - No Cached
  • Nathan Goodyear on 21 Jul 14
     
    2012 WHO review on EDCs
Nathan Goodyear

Taylor & Francis Online :: The microbiome as a target for endocrine disruptors: Novel c... - 0 views

www.tandfonline.com/...23273739.2014.964539

EDC endocrine disrupting chemicals gut flora gut microbiome gut microbiota Testosterone autoimmune disease

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16184081

endocrine disrupting chemicals hormone hormones cortisol cortisone endocrine disruptors EDC 11-betaHSD 11-betaHSD1 11beta-HSD2

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

Early life events predict adult testicular function; data derived from the Western Aust... - 0 views

www.ncbi.nlm.nih.gov/...27340882

Testosterone weight obesity smoking hormones estrogen low t low Testosterone men men's health

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • Nathan Goodyear on 30 Jun 16
     
    optimal weight associated with higher testicular volume and Testosterone levels in men.  Maternal smoking and higher cord bleed estrogens associated with lower sperm output.  This would with the other literature on EDCs.
Nathan Goodyear

Effects of endocrine disruptors on obesity. [Int J Androl. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18315718

obesity endocrine disruptors toxins toxicity

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis
  • The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.
  • Nathan Goodyear on 06 Apr 11
     
    Effects of endocrine disruptors on obesity.
Nathan Goodyear

Benzyl butyl phthalate induces epigenetic stress to enhance adipogenesis in mesenchymal... - 0 views

www.sciencedirect.com/...S0303720716301526

phthalates EDC endocrine disrupting chemicals obesity epigenetics

shared by Nathan Goodyear on 06 Jun 16 - No Cached
  • Nathan Goodyear on 06 Jun 16
     
    Phthalates effect genetic expression of fat prior to birth.  This is science, not politics.
Nathan Goodyear

http://ehp.niehs.nih.gov/wp-content/uploads/advpub/2016/5/EHP205.acco.pdf - 0 views

ehp.niehs.nih.gov/...EHP205.acco.pdf

obesity bisphenol A BPA EDC toxins environmental toxins endocrine disrupting chemicals

shared by Nathan Goodyear on 08 Jun 16 - No Cached
  • Nathan Goodyear on 08 Jun 16
     
    mothers with BPA exposure and thus prenatal exposure, increases risk of obesity risk in child.
Nathan Goodyear

Dog sperm quality decline is blamed on pet food chemicals | New Scientist - 0 views

www.newscientist.com/...s-blamed-on-pet-food-chemicals

sperm count low T low Testosterone environment EDC endocrine disrupting chemicals male fertility

shared by Nathan Goodyear on 10 Aug 16 - No Cached
  • Nathan Goodyear on 10 Aug 16
     
    26 year study of dogs finds declining sperm count equivalent to that in men.  The decline was found to occur at a rate of 1.2% to 2.5% annually over course of study.  The authors pointed to EDC's in food.
Nathan Goodyear

Bisphenol A and Metabolic Syndrome: Results from NHANES - 0 views

www.hindawi.com/...598180

metabolic syndrome MetS bisphenol A BPA EDC endocrine disruptors

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Bisphenol A clearly associated with increased risk of MetS.
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23941471

BPA Bisphenol A Bisphenol-A endocrine disruptor EDC

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

Actions of Estrogens and Endocrine Disrupting Chemicals on Human Prostate Stem/Progenit... - 0 views

www.ncbi.nlm.nih.gov/...PMC3249013

prostate cancer EDC xenoestrogens endocrine disrupting chemicals estrogen men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Endocrine Disrupting chemicals, xenoestrogens, alter the hormone receptors very early. Increased estrogenic load with the change in ER increase prostate cancer.
Nathan Goodyear

Environmental/lifestyle effects on spermatogenesis - 0 views

rstb.royalsocietypublishing.org/...1697.full

sperm count xenoestrogens EDC endocrine disrupting chemicals endocrine disruptor low T Testosterone men male fertility

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    The environment is playing a role in reduced testicular function in men.
Nathan Goodyear

Cadmium - a metallohormone? - 0 views

www.ncbi.nlm.nih.gov/...PMC2709711

cadmium ER alpha ER-alpha ER estrogen receptors receptor androgen AR hormones endocrine disruptors endocrine disrupting chemicals EDC heavy

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, ... - 0 views

press.endocrine.org/...jc.2014-2555

phthalate phthalates EDC endocrine disrupting chemicals low T low Testosterone low T Testosterone hormone hormones

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Phthalate exposure is a cause of low Testosterone in men, women, and children.   In boys 6-12, exposure was associated with a 24-34% reduction in Testosterone.
Nathan Goodyear

PLOS ONE: Persistent Organic Pollutants and Early Menopause in U.S. Women - 0 views

journals.plos.org/...article

EDC endocrine disrupting chemicals women hormone hormones female xenoestrogens endocrine disruptors menopause

shared by Nathan Goodyear on 30 Jan 15 - No Cached
  • Nathan Goodyear on 30 Jan 15
     
    study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.
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