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Nathan Goodyear

Association Between Endogenous Sex Hormones and Liver Fat in a Mult... - PubMed - NCBI - 0 views

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    Time that physicians start following the science.  Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women.  Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women.  The opposite was found to be true in men.  Higher Estradiol levels were found to be associated with increased fatty liver in both sexes.  However, the statistical significance was higher with men.  Higher SHBG was associated with lower fatty liver incidence in men.  
Nathan Goodyear

Fructose Consumption as a Risk Factor for Non-alcoholic Fatty Liver Disease - 0 views

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    Fructose upregulates fructokinase activity and this increase liver triglyceride production increasing non-alcoholic fatty liver disease also known as NAFLD.
Nathan Goodyear

Epidemiology of non-alcoholic fatty liver disease. [Dig Dis. 2010] - PubMed result - 0 views

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    non-alcoholic fatty liver disease the result of Metabolic syndrome.  New epidemic associated with obesity. Scary statistics about the children of America.
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

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    with an estimated 25% of Americans with non-alcoholic fatty liver disease (NAFLD), elevated liver enzymes are becoming a more common finding.  Nice review article on what the tests mean and what disease are underlying.
Nathan Goodyear

Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent ... - 0 views

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    Low Testosterone increased nonalcoholic fatty liver disease in men. The prevalence of NAFLD reached 85% with Total Testosterone was < 300 ng/dl.  Free Testosterone required a greater drop to increase the NAFLD, but it to still was found to be associated.
Nathan Goodyear

N-Acetylcysteine Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Dis... - 0 views

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    Oral NAC useful for elevated liver enzymes in NAFLD
Nathan Goodyear

Plasma Adiponectin in Nonalcoholic Fatty Liver Is Related to Hepatic Insulin Resistance... - 0 views

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    in those with nonalcoholic fatty liver disease, low adiponectin is associated with the insulin resistance, not the NAFLD.  But of course, insulin resistance leads to NAFLD
Nathan Goodyear

Uric acid induces hepatic steatosis by generatio... [J Biol Chem. 2012] - PubMed - NCBI - 0 views

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    Elevated uric acid levels up regulate fructose metabolism to triglycerides and fatty liver.  This study finds that liver mitochondrial oxidative stress is also evident.  This mitochondrial dysfunction also leads to compromised ATP production and fat accumulation specifically through inhibition of aconitase..
Nathan Goodyear

Nonalcoholic Fatty Liver Disease in Children - 0 views

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    non-alcoholic fatty liver disease is the new epidemic.  But the scary point is NAFLD is found in many of our children.  As goes obesity, so goes NAFLD
Nathan Goodyear

The obesity epidemic and nonalcoholic fatty liver ... [Curr Gastroenterol Rep. 2008] - ... - 0 views

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    obesity and non-alcoholic fatty liver disease are one in the same.
Nathan Goodyear

Mediterranean diet and non-alcoholic fatty liver disease: the need of extended and comp... - 1 views

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    Mediterranean diet decreases fatty liver deposits in NAFLD at 6 months.
Nathan Goodyear

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individual... - 0 views

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    Mediterranean diet reduced insulin resistance and liver steatosis in those with NAFLD.
Nathan Goodyear

Adherence to the Mediterranean diet is associated with the severity of non-al... - 0 views

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    In those with NAFLD, mediterranean diet associated with reduced insulin resistance and reduced severity of liver disease; it did not resolve NAFLD
Nathan Goodyear

Polychlorinated biphenyls, lead, and... [Environ Health Perspect. 2010] - PubMed - NCBI - 0 views

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    PCBs, Pb, and Hg associated with elevated liver enzymes, and non-alcohol fatty liver disease.  
Nathan Goodyear

High Fructose Feeding Induces Copper Deficiency in... [J Hepatol. 2011] - PubMed - NCBI - 0 views

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    high Fructose dietary intake results in Copper deficiency.  Result is increase in non-alcoholic fatty liver.
Nathan Goodyear

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Developmen... - 0 views

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    Vicious cycle.  High fructose intake increases uric acid production.  Hyperuricemia then leads to further Fructose metabolism.  This study finds that hyperuricemia upregulates the fructokinase enzyme that is the first step in fructose metabolism.  This upregulation will increase fructose metabolism and increase fat accumulation in the liver.
Nathan Goodyear

Effect of Testosterone Administration on Liver Fat in Older Men With Mobility Limitatio... - 0 views

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    Testosterone replacement in older men with low T not shown to improve liver fat content.  This has obvious implications to non-alcoholic hepatic steatosis.
Nathan Goodyear

Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis - 0 views

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    metabolic endotoxemia plays role in NAFLD.  Gut bacterial balance plays a role in NAFLD.
Nathan Goodyear

Pathogenesis of non-alcoholic fatty liver disease - 0 views

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    The fastest growing liver disease today is NAFLD, which is a direct result of the rising obesity epidemic.  This is a good review of the current understanding on the pathophysiology of NAFLD.
Nathan Goodyear

A low level of serum total testosterone is independently associated with nonalcoholic f... - 0 views

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    low Testosterone is associated with NAFLD
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