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Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

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    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
Nathan Goodyear

BMC Microbiology | Full text | The Firmicutes / Bacteroidetes ratio of the human microb... - 0 views

  • The microbiota of the large intestine plays an important role in host metabolism and maintenance of host health
  • Our results defining a standard adult profile, together with previous reports, showed that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
  • Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
  • ...12 more annotations...
  • In infant fecal microbiota, we observed Bifidobacterium as the dominant group
  • this observation is strongly related to diet, being enhanced by breast feeding
  • Significant higher numbers of Bifidobacterium were observed in infants versus adults and seniors
  • the gastrointestinal tract is first colonized by facultative anaerobes, such as E. coli
  • Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
  • diet change must be considered among the primary causes for such a shift of microbiota between infants and adults.
  • In the case of elderly subjects, our qPCR results indicated a significant increase in the counts of E. coli when compared to adults. This data is consistent with other publications indicating that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
  • a number of authors reported a reduction in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
  • The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota status
  • Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those obtained by Ley et al
  • Compared with young adults, the elderly have a different digestive physiology, characterized at a physiological level by a reduction in transit and of digestive secretions
  • The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age
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    Good discussion of the gut microbiome.  Age effects the gut bacteria balance.  The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study.  Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
Nathan Goodyear

Inadequate Corpus Luteal Function in Women with Benign Breast Diseases -- SITRUK-WARE e... - 0 views

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    estrogen dominance (high estradiol/low progesterone) increases risk of non-benign breast disease
Nathan Goodyear

Estrogen receptor related beta is expressed in human endometrium throughout the normal ... - 0 views

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    ER-beta found throughout both the proliferative and secretory phases of the menstrual cycle.  ER-beta expression was higher in the proliferative versus the secretory phases, though not statistically significant.  This makes since as estrogen stimulation dominates the proliferative phase.  Additionally, ER-beta expression was found throughout all levels of the endometrium and the myometrium.
Nathan Goodyear

Oestrogen receptor α and β mRNA expression in human endometrium throughout th... - 0 views

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    Estrogen receptors alpha and beta show dominance in the proliferative phases, with alpha isoform predominating.  In the secretory phase, less expression of ER was present. ER alpha was predominantly expressed in the epithelial and stromal cells in the proliferative phase.  ER beta was predominantly expressed in glandular cells in the same proliferative phase.   in the luteal phase, ER alpha expression declined in the funtionalis layers.  ER alpha in the basalis remained unchanged.  ER beta in the functionalis layers also declined in the luteal phase.   No relative change was found in the weak expression of ER alpha/beta in the myometrium.
Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Differe... - 0 views

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    progesterone receptor status varies through a woman's menstrual cycle. PR-A dominates throughout, but the PR-A to PR-B ratio declines up to ovulation.
Nathan Goodyear

Adipose tissue macrophages: p... [Curr Opin Clin Nutr Metab Care. 2011] - PubMed - NCBI - 0 views

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    adipose tissue changes the macrophage type from M2 to M1 dominance.  This reveals the microenvironment found in adipose tissue and the effect on the adipose tissue macrophages.
Nathan Goodyear

Progesterone Receptor-A and -B Have Opposite Effects on Proinflammatory Gene Expression... - 0 views

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    Progesterone is known to have anti-inflammatory action.  This study looked at the anti-inflammatory action of progesterone on the myometrium of the uterus during pregnancy.  The anti-inflammatory effect, in this study, was through Progesterone Receptor B.  There was a change in the dominance to PR A late in pregnancy.  This would promote inflammatory signaling and thus contractions with the onset of labor.
Nathan Goodyear

Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight ... - 0 views

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    diet dominance type favors different bacterial balance in the gut that favors systemic inflammation.  Particularly, a high fat diet is associated with systemic hsCRP.
Nathan Goodyear

The Evolving Role of Oestrogens and Their Receptors in the Development and Progression ... - 0 views

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    This study points out, that it is not the androgens, but the high aromatase activity and resultant Estradiol production that promotes prostate disease.  Take this together with high ER alpha dominance and one has a recipe for disease.
Nathan Goodyear

Expression of estrogen receptor beta in colon cancer progression. - Abstract - Europe P... - 0 views

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    ER beta expression is dominant in healthy colon epithelium.  This study found that as colon disease progressed, ER beta expression declined.  So that, early disease was associated with the highest level of ER beta expression.
Nathan Goodyear

Long-term effects of the rhaponti... [J Steroid Biochem Mol Biol. 2012] - PubMed - NCBI - 0 views

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    No long-term negative effects seen with Err 731 supplementation.  Particularily, the authors were looking for endometrial stimulation.  But, previous studies had shown a dominant ER-beta affinity, which would not favor endometrial stimulation.
Nathan Goodyear

Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type... - 0 views

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    Study finds no improvement in sexual desire and/or ED in older, obese men with Type II diabetes by Testosterone therapy over 40 weeks.   There is so much wrong with this study.  The authors, by design, assume that Testosterone is all there is.  No assessment of Testosterone metabolism and or its effects on inflammation was designed into this study.  These men are known to have increased inflammatory cytokine production and likely are aromatase dominant.  Given these men Testosterone may just be throwing fuel on the biochemical fire.
Nathan Goodyear

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role... - 0 views

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    sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance
Nathan Goodyear

Expression and Subcellular Localization of Estrogen Receptors α and β in Huma... - 0 views

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    ER alpha and ER beta expressed on fetal fat cells.  The authors of this article propose that ER alpha plays the dominant in fetal adipocyte differentiation.
Nathan Goodyear

Treatment of multiple sclerosis with the pregnanc... [Ann Neurol. 2002] - PubMed - NCBI - 0 views

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    Estriol, the dominant estrogen in pregnancy shown to decrease MS symptoms.  When Estriol was stopped, MS lesions relapsed.  Estriol binds to ERbeta at a rate of 5:1 compared to ER alpha.
Nathan Goodyear

Steroid hormones in multiple sclerosis. [J Neurol Sci. 2005] - PubMed - NCBI - 0 views

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    Pregnancy has a positive effect on MS patients, especially during the 3rd trimester.  Rebound of MS increases in the postpartum period.  Estriol is the dominant pregnancy estrogen.  Progesterone is also produced at high levels.  The withdrawal of these hormones in the postpartum period are likely to lead to this rebound in MS.
Nathan Goodyear

Menopause and the Metabolic Syndrome - 0 views

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    Menopause transition can become a Testosterone dominant phase associated with increased CVD and increased metabolic syndrome.
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