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ERr 731 extract from Siberian Rhubarb found to be effective against anxiety related to menopause.

ERr 731, which is an extract from Siberian Rhubarb, found to be effective against menopausal symptoms in women.

It is always important to work out the biochemical mechanism of action.  Study finds Siberian Rhubarbs mechanism of action is through activation ER-beta receptors.  No activity/affinity for ER-alpha found in this study.  This is important as the ER-beta provides an anti-inflammatory, antigrowth signal.

Study finds that Err 731, extract of Siberian Rhubarb, strong affinity for ER-beta and weak activity for ER-alpha in bone, though none found present in endometrial cells.  This is the second study to provide evidence of molecular mechanism of action through ER-beta receptors.

Study finds Err 731 effective against menopausal symptoms.

No long-term negative effects seen with Err 731 supplementation.  Particularily, the authors were looking for endometrial stimulation.  But, previous studies had shown a dominant ER-beta affinity, which would not favor endometrial stimulation.