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Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

www.ncbi.nlm.nih.gov/...PMC3751545

IV vitamin C dosing ascorbic acid inflammation disease cancer IV vitamin C intravenous vitamin C IV intravenous vitamin C vitamin C CRP therapy treatment alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...25 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  • large doses given intravenously may result in maximum plasma concentrations of roughly 30 mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
  • oral intake of vitamin C exceeded 200 mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200 μM.
  • Nathan Goodyear on 26 Aug 14
     
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
Nathan Goodyear

Inflammation in Response to Glucose Ingestion Is Independent of Excess Abdominal Adipos... - 0 views

jcem.endojournals.org/...4071.abstract

PCOS polycystic ovarian syndrome inflammation TNF-alpha CRP women androgens testosterone

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat.  Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
Nathan Goodyear

CIRCULATING INFLAMMATORY MARKERS IN POLYCYSTIC OVARY SYNDROME: A SYSTEMATIC REVIEW AND ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3079565

PCOS polycystic ovarian syndrome inflammation CRP IL-6 TNF-alpha

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    It is well known that obesity increases CRP.  However, in this meta-analysis, CRP elevation in women with PCOS was found to be independent from obesity and as they concluded: "...chronic low-grade inflammation that may underpin the pathogenesis of this disorder".
Nathan Goodyear

Relationship between endogenous testosterone and cardiovascular risk in early postmenop... - 0 views

www.metabolismjournal.com/...abstract

testosterone women high elevated CRP inflammation BMI obesity overweight post-menopausal CVD

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Body mass index and waist circumference were significantly higher in the group with testosterone levels
  • Median CRP levels were greater in the group with higher testosterone level
  • ET-1 levels were also higher in women with greater testosterone levels
  • ...2 more annotations...
  • An association of testosterone with CRP (r = 0.416, P = .004) and ET-1 (r = 0.323, P = .031) was observed
  • Testosterone was also associated with waist circumference and blood pressure (P = .001)
  • Nathan Goodyear on 10 May 12
     
    testosterone associated with elevated CRP, increase BMI, and increased waist circumference in early, post-menopausal women.
Nathan Goodyear

International Journal of Obesity - Obesity is the major determinant of elevated C-react... - 0 views

www.nature.com/...0802609a.html

inflammation adipose tissue obesity overweight CRP metabolic syndrome

shared by Nathan Goodyear on 15 Mar 12 - No Cached
  • Nathan Goodyear on 15 Mar 12
     
    another study showing the link between obesity and increased CRP.  In this article, the elevated CRP was associated/linked with metabolic syndrome.  Again, suggesting adipose tissue as the source of inflammation.
Nathan Goodyear

Endogenous sex hormones and C-reactive protein in healthy postmenopausal wome... - 0 views

onlinelibrary.wiley.com/...full

CRP women hormone hormones postmenopause menopause estradiol estrone estrogen Testosterone free androgen index

shared by Nathan Goodyear on 25 Feb 14 - No Cached
  • sex hormones such as E1, E2, FEI, T and FAI were also strongly positively associated with age-adjusted CRP levels whereas SHBG showed a strong negative association
  • An intriguing aspect is the observation that higher plasma concentrations of both oestrogenic and androgenic components were related to increased CRP
  • Nathan Goodyear on 25 Feb 14
     
    Study finds that lower SHBG, higher Estradiol, Estrone, Testosterone levels, and free androgen index is associated with increased CRP in "healthy" postmenopausal women.
Nathan Goodyear

Endogenous androgen levels and cardiovascular risk profile i... : Menopause - 0 views

journals.lww.com/...and_cardiovascular_risk.7.aspx

CVD cardiovascular postmenopause CRP women hormone hormones Testosterone SHBG

shared by Nathan Goodyear on 25 Feb 14 - No Cached
  • Nathan Goodyear on 25 Feb 14
     
    Study finds low SHBG associated with increased CRP and CVD in post menopause women.  No significant association with androgens and CRP were found.
Nathan Goodyear

Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC2784979

CRP PCOS BMI

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    Study finds no association between CRP and PCOS in normal weight women.  As BMI increased in women with PCOS, so did CRP.
Nathan Goodyear

C-reactive protein, the metabolic syndrome, and pr... [Circulation. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15262834

CRP metabolic syndrome cardiovascular disease

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women
  • both CRP and MetS are independent predictors of new CVD events.
  • Nathan Goodyear on 11 Feb 11
     
    elevated CRP helps predict metabolic syndrome and cardiovascular disease
Nathan Goodyear

Acute phase protein and cytokine levels in... [Brain Behav Immun. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23999491

CRP inflammation saliva salivary testing

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • Nathan Goodyear on 22 Oct 14
     
    Salivary CRP correlates with serum CRP in adolescents with inflammation.
Nathan Goodyear

Validation of a high-sensitivity assay for... [Brain Behav Immun. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21236331

CRP inflammation saliva testing salivary

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • Nathan Goodyear on 22 Oct 14
     
    Exciting: salivary CRP found to correlate with serum CRP.
Nathan Goodyear

The Prostate Cancer Patient Had Higher C-Reactive Protein Than BPH Patient - 0 views

www.ncbi.nlm.nih.gov/...PMC3580310

prostate cancer inflammation CRP

shared by Nathan Goodyear on 23 Jun 19 - No Cached
  • Nathan Goodyear on 23 Jun 19
     
    positive correlation between serum CRP and tumor stage is observed in prostate cancer patients and a correlation was also observed between the rise in CRP and faster progression of the tumor. This result proves that inflammation participates in tumor progression
Nathan Goodyear

Low vitamin C levels may raise heart failure patients' risk / American Heart Association - 0 views

newsroom.heart.org/...c-levels-may-raise-217754.aspx

vitamin C heart failure cardiovascular disease hs-CRP crp inflammation

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    patients with heart failure and low vitamin C levels have higher inflammation as measured by hs-CRP and elevated risk of worse outcomes
Nathan Goodyear

C-Reactive Protein as a Cardiovascular Risk Factor : More Than an Epiphenomenon? -- Lag... - 0 views

circ.ahajournals.org/...96

CRP cardiovascular disease

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • CRP constitutes an independent cardiovascular risk factor
  • Nathan Goodyear on 04 Feb 11
     
    CRP is an independent marker for future cardiovascular disease
Nathan Goodyear

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Am... - 0 views

circ.ahajournals.org/...731

CRP cardiovascular risk women

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • CRP is a strong independent risk factor for cardiovascular disease that adds to the predictive value of risk models based on usual factors alone.
  • Nathan Goodyear on 04 Feb 11
     
    CRP is marker for cardiovascular risk in women
Nathan Goodyear

Elevated C-reactive protein and homocysteine value... [Atherosclerosis. 2003] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...12535752

hypothyroidism hypothyroid CRP

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • This is the first paper to show that CRP values increase with progressive thyroid failure and may count as an additional risk factor for the development of coronary heart disease in hypothyroid patient
  • Nathan Goodyear on 01 Feb 11
     
    inflammation, CRP, associated with hypothyroidism
Nathan Goodyear

Low Testosterone and High C-Reactive Protein Concentrations Predict Low Hematocrit in T... - 0 views

care.diabetesjournals.org/...2289.full

low testosterone CRP cardiovascular disease

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • In these patients, hematocrit is also inversely related to CRP concentration.
  • Nathan Goodyear on 12 Apr 11
     
    low T associated with elevated CRP and thus increased cardiovascular risk
Nathan Goodyear

European Journal of Clinical Nutrition - C-reactive protein concentration and concentra... - 0 views

www.nature.com/...1601667a.html

IV vitamin C intravenous IV vitamin C antioxidants CRP ROS vitamins

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study shows that inflammation, CRP in this study, was inversely associated with low antioxidants ie. vitamin C.  This makes since as ROS are known to stimulate inflammation.  Vitamin C should be considered as a therapeutic option in those with inflammation.
Nathan Goodyear

Human C-reactive protein and the metabolic syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC2921825

CRP metabolic syndrome cardiovascular disease

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    CRP and metabolic syndrome
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