Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors i... - 0 views
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The presence and activity of PR significantly affect the prognostic value of ER.
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The observed loss of PR protein expression in a subset of ER+/PR+ breast cancers, because of hypermethylation or deletion of the PR gene locus, results in the loss of ER prognostic value
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These findings emphasize the clinical value of assessing both PR and ER expression in breast cancer samples
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WOW!! study finds that progesterone through PR activity antagonizes ER protein expression by the cell. This has huge implications in breast cancer and possible prostate cancer. But then again, women don't need progesterone; only estrogen. The presence of PR correlates with improved clinicopathological outcomes. The authors do seem to get confused about progesterone and progestins. They are not one in the same.