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Nathan Goodyear

Aromatase and regulation of the estrogen-to... [Ann N Y Acad Sci. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24684533

aromatase aromatase activity vitamin D estrone E1 inflammation RA rheumatoid arthritis

shared by Nathan Goodyear on 07 Apr 14 - No Cached
  • Nathan Goodyear on 07 Apr 14
     
    Study looked at inflammatory markers in RA.  The authors point to high aromatase activity, low androgens, and elevated estrone in synovial fluid as an indicator of a link between aromatase activity and inflammation production through E1 production.  The authors also point to the 16 alpha metabolite pathway as pro-inflammatory as well.  One very interesting point made by the authors is that vitamin D down regulates aromatase activity.  In addition to NK-kappaB inhibition, this may be another mechanism by which vitamin D reduces inflammation.
Nathan Goodyear

Estrogen Receptor-Related Receptor α Mediates Up-Regulation of Aromatase Expr... - 0 views

mend.endojournals.org/...1175.abstract

ER-alpha estrogen receptors aromatase prostate men male PGE2 hormone hormones

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    ER alpha increases aromatase expression in the prostate.  PGE2 increased the ER alpha receptor.  Vicious cycle in men.  Increased aromatase activity increases estrogen production which increases ER alpha (pro growth) and further aromatase activity.
Nathan Goodyear

Aromatase inhibitors for male infertility. [J Urol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11792932

male infertility anastrozole arimidex aromatase inhibitor inhibition Testosterone:estradiol

shared by Nathan Goodyear on 26 Feb 12 - No Cached
  • Nathan Goodyear on 26 Feb 12
     
    aromatase inhibitor, arimidex (anastrozole), shown to be effective therapy in male infertility in those with high aromatase activity.  The effect was seen through improved Testosterone:Estradiol ratio through aromatase inhibition.
Nathan Goodyear

Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity - 0 views

lup.sagepub.com/...635.short

aromatase testosterone estrogen estradiol IL-6 TNF-alpha IL-1 autoimmune disease inflammation inflammatory cytokines men hormones immune system

shared by Nathan Goodyear on 29 Apr 12 - No Cached
  • Nathan Goodyear on 29 Apr 12
     
    high conversion of testosterone to estrogen conversion in men is from increased aromatase activity.  Inflammatory cytokines, such as IL-6, TNF-alpha, has been shown to increase aromatase activity and at the same time increase IL-6 and other inflammatory cytokines is the result of increased aromatase activity.
Nathan Goodyear

Aromatase and regulating the estrogen:androgen ratio in the prostate gland - 0 views

www.sciencedirect.com/...S0960076009002696

estrogen estradiol Testosterone T:E2 prostate cancer prostate BPH male men hormone hormones cancer health ER alpha ER beta aromatase activity aromatase

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    This article summarizes it all.  With age, Testosterone declines and estrogen production, through elevated aromatase activity, increases.  This results in a decline in the Testosterone:estradiol ratio.  This has been clearly implicated in both benign and disease states of the prostate.  The evidence points to aromatase activity and estrogen in the prostate to poor prostate health.  Additionally, this article points out the impact of ER alpha and ER beta on the translation of the message of Estrogen.
Nathan Goodyear

Immunohistochemical evidence of the existence and localization of aromatase in human pr... - 0 views

onlinelibrary.wiley.com/...abstract

aromatase aromatase inhibitor prostate inflammation Testosterone Estradiol

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    aromatase activity is present in the prostate.  The conversion of Testosterone to Estradiol via aromatase activity has been shown to contribute to inflammation and prostate enlargement.
Nathan Goodyear

Coadministration of anastrozole sustains therapeut... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24119010

Testosterone aromatase aromatase activity estradiol anastrazole aromatase inhibitor aromatase inhibitors aromatase inhibition men male hormone hormones

shared by Nathan Goodyear on 19 Feb 14 - No Cached
  • Nathan Goodyear on 19 Feb 14
     
    First, Testosterone pellets are not the way to go.  Historically, these will go the way of all the implantable contraceptive devices.  However, the conclusion of this study is good and confirms the benefit of anastrazole to inhibit aromatase activity and help to maintain Testosterone levels.
Nathan Goodyear

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in... - 0 views

www.ncbi.nlm.nih.gov/...26950683

low T low Testosterone Testosterone prostate men male hormones PSA LUTS aromatase aromatase inhibition

shared by Nathan Goodyear on 08 Mar 16 - No Cached
  • Nathan Goodyear on 08 Mar 16
     
    study finds both Testosterone therapy and aromatase inhibition in men > 65 both increase Testosterone levels.  Increase in prostate size was only seen in the Testosterone only group; not in the AI group.  This implicates aromatase activity in the increase in prostate volume.  
Nathan Goodyear

Stimulation of aromatase activity in bre... [Mol Cell Endocrinol. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7895904

inflammatory cytokines inflammation TNF-alpha aromatase activity estrone testosterone adipose fat tissue breast men women hormones androstenedione

shared by Nathan Goodyear on 29 Apr 12 - No Cached
  • Nathan Goodyear on 29 Apr 12
     
    inflammatory cytokine, TNF-alpha, increases aromatase activity.  This article discusses the increased production of estrone from androstenedione from aromatase activity in fat tissue in the breast.
Nathan Goodyear

Oestrogens and prostate cancer - 0 views

erc.endocrinology-journals.org/...187.full.pdf

aromatase activity aromatase activity prostate cancer disease Testosterone estradiol male hormone hormones

shared by Nathan Goodyear on 24 Sep 13 - No Cached
  • Nathan Goodyear on 24 Sep 13
     
    Study confirms aromatase activity in the prostate itself. Systemic Testosterone and Estradiol evaluation (ie blood) will not necessarily reflect endogenous prostate aromatase activity.
Nathan Goodyear

Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase express... - 0 views

joe.endocrinology-journals.org/...89.full

prostate BPH PGE2 inflammation men male hormone hormones aromatase estradiol estrone stroma

shared by Nathan Goodyear on 19 Sep 12 - No Cached
  • Nathan Goodyear on 19 Sep 12
     
    Increased aromatase activity is found in BPH.  PGE2 increases aromatase activity and thus increases Estradiol production in the stroma of the prostate.
Nathan Goodyear

Aromatase inhibitors in men: effects and therapeutic options - 0 views

www.ncbi.nlm.nih.gov/...PMC3143915

arimidex anastrozole aromatase inhibition inhibitor low T testosterone Testosterone:estradiol

shared by Nathan Goodyear on 26 Feb 12 - No Cached
  • Nathan Goodyear on 26 Feb 12
     
    Aromatase inhibition using arimidex, anastrozole, shown to be an effective therapy to raise testosterone levels in men with low T and high aromatase activity.
Nathan Goodyear

Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testost... - 0 views

jcem.endojournals.org/...1174.full

aromatase inhibitor Testosterone estradiol estrogen men male hormon hormoens psa

shared by Nathan Goodyear on 23 Sep 13 - No Cached
  • Nathan Goodyear on 23 Sep 13
     
    Study looked at aromatase activity in androgen production in older men.  The study found that aromatase inhibition with arimidex increased Testosterone production.  PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.
Nathan Goodyear

Hops (Humulus lupulus) inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Mali... - 0 views

www.ncbi.nlm.nih.gov/...PMC3252489

Hops estrogen aromatase inhibition aromatase inhibitor aromatase inhibitors aromatase hormone hormones

shared by Nathan Goodyear on 20 May 14 - No Cached
  • Nathan Goodyear on 20 May 14
     
    Hops inhibits aromatase activity.
Nathan Goodyear

Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expressi... - 0 views

www.ncbi.nlm.nih.gov/...PMC2778514

cyclooxygenase aromatase inhibition cancer COX2 aromatase melatonin aromatase inhibitor

shared by Nathan Goodyear on 17 Nov 21 - No Cached
  • Nathan Goodyear on 17 Nov 21
     
    Melatonin downregulates aromatase expression through COX2
Nathan Goodyear

Full Text: Editorial - 0 views

jrheum.com/...419.html

aromatase activity testosterone estrogen autoimmune disease lupus RA inflammation inflammatory cytokines IL-6 TNF-alpha IL-1 men women hormones

shared by Nathan Goodyear on 29 Apr 12 - No Cached
  • Nathan Goodyear on 29 Apr 12
     
    high aromatase activity and conversion of testosterone to estrogen conversion plays a role in lupus and RA.  Inflammatory cytokines are shown to increase aromatase activity.
Nathan Goodyear

Estrogen and prostate cancer: An eclipsed truth in an androgen-dominated scenario - Car... - 0 views

onlinelibrary.wiley.com/...abstract

aromatase aromatase activity Estradiol Estrogen ER alpha prostate cancer prostate cancer disease

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Aberrant aromatase expression and activity has been reported in prostate tumor tissues and cells, implying that androgen aromatization to estrogens may play a role in prostate carcinogenesis or tumor progression
  • imbalance of their expression may be critical to determine the ultimate estrogen effects on prostate cancer cells
  • In prostate cancer, ERβ activation appears to limit cell proliferation directly or through ERα inhibition, and loss of ERβ has been consistently associated with tumor progression
  • Nathan Goodyear on 21 Aug 13
     
    High aromatase activity and ER alpha expression/signaling associated with prostate disease.
Nathan Goodyear

Inhibition of aromatase activity by flavonoids. [Arch Pharm Res. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...10403137

aromatase inhibition flavonoids chrysin

shared by Nathan Goodyear on 01 Mar 11 - No Cached
  • Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL)
  • Nathan Goodyear on 01 Mar 11
     
    flavonoids inhibit aromatase activity
Nathan Goodyear

inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induce... - 0 views

ajprenal.physiology.org/...F634.full.pdf

testosterone hormone hormones kidney kidneys diabetes DM renal system aromatase

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    Study finds that inhibition of aromatase activity in diabetic male rats provided renal protection. There has been debate about the effects of testosterone therapy on the renal system. However, I propose that aromatase activity and conversion to estrogen is the negative effects of Testosterone. Other than over dosing men. Though this is a rat study, this study does support the theory.
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