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Nathan Goodyear

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer ... - 0 views

  • sulforaphane, a natural compound derived from broccoli/broccoli sprouts
  • Sulforaphane inhibits breast CSCs
  • These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells
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    Sulforaphane, naturally found in broccoli  inhibits breast CSCs
Nathan Goodyear

Regulation of estrogen receptor α expression in human breast cancer cells by ... - 0 views

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    Sulforaphane shown to inhibit ER alpha expression in human breast cancer cell lines.  Sulforaphane is from cruciferous vegetables.
Nathan Goodyear

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arres... - 0 views

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    Good review on the mechanism of sulforaphane in cancer treatment.
Nathan Goodyear

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role... - 0 views

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    sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance
Nathan Goodyear

Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotest... - 0 views

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    sulforaphane reduces DHT through increased metabolism of DHT.
Nathan Goodyear

Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts... - 0 views

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    sulforaphane proves to have activity against H. pylori.
Nathan Goodyear

ScienceDirect - Clinical Immunology : Oral sulforaphane increases Phase II antioxidant ... - 0 views

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    sulphoraphane increases Phase II detoxification
Nathan Goodyear

Access : Sulforaphane Inhibits Mitotic Clonal Expansion During Adipogenesis Through Cel... - 0 views

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    sulphoraphane shown to arrest fat cell growth.  Sulphoraphane decreased PPAR-gamma and C/EBP-alpha expression as well as suppressing the cell growth cycle.  Obvious implications in weight loss
Nathan Goodyear

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
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    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
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